SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		5 / 12 THR A  29
PHE A  26
PHE A  22
LEU A  11
TYR A 228
 None
 1.30A 3apxA-2yytA:
undetectable		 3apxA-2yytA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		4 / 7 TYR A  40
VAL A  48
VAL A  86
GLY A  82
 None
 0.99A 3kmoB-2yytA:
undetectable		 3kmoB-2yytA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		5 / 9 GLY A  82
ALA A  83
ASP A  84
ILE A  47
LEU A  78
 None
 0.90A 3ogpA-2yytA:
undetectable		 3ogpA-2yytA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		5 / 9 GLY A  82
ALA A  83
ASP A  84
ILE A  47
LEU A  78
 None
 0.87A 3ogpB-2yytA:
undetectable		 3ogpB-2yytA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		3 / 3 HIS A 147
SER A 155
GLU A 154
 None
 0.88A 3s8pA-2yytA:
undetectable		 3s8pA-2yytA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		4 / 7 GLY A  82
ALA A  83
ASP A  84
ILE A  47
 None
 0.65A 3t3cA-2yytA:
undetectable		 3t3cA-2yytA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		3 / 3 LEU A 179
ASP A 210
TYR A 211
 None
 0.64A 4qc6B-2yytA:
undetectable		 4qc6B-2yytA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		5 / 12 LEU A  78
ALA A  83
ASN A  87
ALA A 100
ILE A 101
 None
 1.10A 4x1yB-2yytA:
undetectable		 4x1yB-2yytA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		4 / 6 VAL A  81
VAL A  86
ILE A   8
PHE A  32
 None
 1.06A 5jw1B-2yytA:
undetectable		 5jw1B-2yytA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		4 / 7 GLY A  82
ALA A  83
ASP A  84
ILE A  47
 None
 0.67A 5kqyB-2yytA:
undetectable		 5kqyB-2yytA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Geobacillus
kaustophilus) 		4 / 6 ARG A 205
ALA A 204
PRO A 201
PHE A   7
 None
 1.24A 5odqA-2yytA:
undetectable		 5odqA-2yytA:
18.21