SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 LEU A 209
LEU A 115
SER A 113
 None
 0.48A 1tlmA-2yyvA:
undetectable		 1tlmA-2yyvA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		4 / 7 ILE A  20
PHE A 114
LEU A 117
ASP A 145
 None
 0.93A 1yc2E-2yyvA:
undetectable		 1yc2E-2yyvA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 11 LEU A 147
ILE A 182
PHE A 203
ASP A 208
SER A 118
 None
 1.47A 3ko0E-2yyvA:
undetectable
3ko0F-2yyvA:
undetectable
3ko0G-2yyvA:
undetectable
3ko0H-2yyvA:
undetectable		 3ko0E-2yyvA:
21.88
3ko0F-2yyvA:
21.88
3ko0G-2yyvA:
21.88
3ko0H-2yyvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 10 ASP A 208
SER A 118
LEU A 147
ILE A 182
PHE A 203
 None
 1.43A 3ko0O-2yyvA:
undetectable
3ko0P-2yyvA:
undetectable
3ko0Q-2yyvA:
0.0
3ko0R-2yyvA:
0.0		 3ko0O-2yyvA:
21.88
3ko0P-2yyvA:
21.88
3ko0Q-2yyvA:
21.88
3ko0R-2yyvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		4 / 6 VAL A 175
ASN A 177
TYR A 171
ILE A 182
 None
 1.07A 3q5sA-2yyvA:
undetectable		 3q5sA-2yyvA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 GLY A 164
GLY A 162
ASP A   3
GLU A 169
ALA A 167
 None
 1.31A 3t7sB-2yyvA:
undetectable		 3t7sB-2yyvA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 GLY A 164
GLY A 162
ASP A   3
GLU A 169
ALA A 167
 None
 1.32A 3t7sD-2yyvA:
undetectable		 3t7sD-2yyvA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 ILE A  29
ALA A  32
LEU A 223
ALA A  37
ILE A 109
 None
 1.13A 3uvvB-2yyvA:
undetectable		 3uvvB-2yyvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		3 / 3 LEU A 148
ILE A 152
ARG A 155
 None
 0.71A 4mk4B-2yyvA:
undetectable		 4mk4B-2yyvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		4 / 4 ILE A 110
ILE A 130
ARG A  15
TYR A 123
 None
 1.45A 4zzbC-2yyvA:
undetectable		 4zzbC-2yyvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 ALA A 111
PRO A  42
PHE A 221
GLY A  39
SER A  38
 None
 0.92A 5hfjB-2yyvA:
undetectable		 5hfjB-2yyvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 ALA A 111
PRO A  42
PHE A 221
GLY A  39
SER A  38
 None
 1.15A 5hfjD-2yyvA:
undetectable		 5hfjD-2yyvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 ALA A 111
PRO A  42
PHE A 221
GLY A  39
SER A  38
 None
 1.02A 5hfjF-2yyvA:
undetectable		 5hfjF-2yyvA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		5 / 12 GLY A 162
HIS A 166
VAL A 153
PHE A 146
VAL A 133
 None
 1.22A 5n0xB-2yyvA:
3.0		 5n0xB-2yyvA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA807_0
(GEPHYRIN)		 2yyv PROBABLE
2-PHOSPHOSULFOLACTAT
E PHOSPHATASE
(Thermotoga
maritima) 		4 / 4 PRO A  77
LEU A 115
VAL A  22
ARG A  24
 None
 1.17A 6fgdA-2yyvA:
undetectable		 6fgdA-2yyvA:
19.71