SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yyy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ASP A  77
GLY A  31
ILE A   7
VAL A 107
ILE A  79
 None
 1.10A 1hpvB-2yyyA:
undetectable		 1hpvB-2yyyA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A 315
ASP A  87
GLY A  11
ALA A  20
 None
None
NAP  A2001 (-3.2A)
None
 0.77A 1n49A-2yyyA:
undetectable		 1n49A-2yyyA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A 336
SER A 332
GLU A 314
ALA A 126
 None
 0.99A 2v32A-2yyyA:
undetectable
2v32B-2yyyA:
undetectable		 2v32A-2yyyA:
22.67
2v32B-2yyyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A 336
SER A 332
GLU A 314
ALA A 126
 None
 1.01A 2v32A-2yyyA:
undetectable
2v32B-2yyyA:
undetectable		 2v32A-2yyyA:
22.67
2v32B-2yyyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A 336
SER A 332
GLU A 314
ALA A 126
 None
 0.97A 2v41G-2yyyA:
undetectable
2v41H-2yyyA:
undetectable		 2v41G-2yyyA:
22.67
2v41H-2yyyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ILE A 269
ARG A 151
ILE A 268
THR A 223
 None
 1.25A 3ia4C-2yyyA:
undetectable		 3ia4C-2yyyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  55
THR A  74
ILE A  75
ASN A   8
 None
None
None
NAP  A2001 (-3.2A)
 0.93A 3p50A-2yyyA:
undetectable		 3p50A-2yyyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  55
THR A  74
ILE A  75
ASN A   8
 None
None
None
NAP  A2001 (-3.2A)
 0.93A 3p50B-2yyyA:
undetectable		 3p50B-2yyyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  55
THR A  74
ILE A  75
ASN A   8
 None
None
None
NAP  A2001 (-3.2A)
 0.93A 3p50C-2yyyA:
undetectable		 3p50C-2yyyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  55
THR A  74
ILE A  75
ASN A   8
 None
None
None
NAP  A2001 (-3.2A)
 0.93A 3p50D-2yyyA:
undetectable		 3p50D-2yyyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A  55
THR A  74
ILE A  75
ASN A   8
 None
None
None
NAP  A2001 (-3.2A)
 0.93A 3p50E-2yyyA:
undetectable		 3p50E-2yyyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A   5
ALA A  82
ILE A  79
THR A  33
ILE A   7
 None
 1.15A 3qfxA-2yyyA:
undetectable		 3qfxA-2yyyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A   5
ALA A  82
ILE A  79
THR A  33
ILE A   7
 None
 1.13A 3qfxB-2yyyA:
undetectable		 3qfxB-2yyyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 142
SER A 143
THR A 146
 None
 0.40A 4luhA-2yyyA:
2.1		 4luhA-2yyyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.13A 4mi4A-2yyyA:
undetectable		 4mi4A-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.12A 4mi4B-2yyyA:
undetectable
4mi4C-2yyyA:
undetectable		 4mi4B-2yyyA:
20.36
4mi4C-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.10A 4mi4A-2yyyA:
undetectable
4mi4C-2yyyA:
undetectable		 4mi4A-2yyyA:
20.36
4mi4C-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.13A 4mj8A-2yyyA:
undetectable
4mj8C-2yyyA:
undetectable		 4mj8A-2yyyA:
20.36
4mj8C-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.11A 4mj8B-2yyyA:
undetectable
4mj8C-2yyyA:
undetectable		 4mj8B-2yyyA:
20.36
4mj8C-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.21A 4mj8C-2yyyA:
undetectable		 4mj8C-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.12A 4r87H-2yyyA:
undetectable		 4r87H-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.18A 4r87I-2yyyA:
undetectable		 4r87I-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 GLY A  14
TYR A  10
ALA A  18
ARG A 279
 None
 1.29A 4yshB-2yyyA:
undetectable		 4yshB-2yyyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 232
GLU A 298
ILE A 156
 None
 0.64A 6f7lB-2yyyA:
5.3		 6f7lB-2yyyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 TYR A  49
ILE A   7
ALA A  20
MET A  23
 None
 1.03A 6hu9m-2yyyA:
undetectable
6hu9q-2yyyA:
undetectable		 6hu9m-2yyyA:
19.78
6hu9q-2yyyA:
16.33