SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yyz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 9 PHE A 207
LEU A   9
VAL A   6
ILE A   4
VAL A 188
 None
 1.22A 1gebA-2yyzA:
undetectable		 1gebA-2yyzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 5 MET A 198
ALA A 201
ILE A 204
ASP A 219
 None
 0.82A 1upfA-2yyzA:
undetectable		 1upfA-2yyzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 7 MET A 198
ALA A 201
ILE A 204
ASP A 219
 None
 0.83A 1upfB-2yyzA:
undetectable		 1upfB-2yyzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 5 MET A 198
ALA A 201
ILE A 204
ASP A 219
 None
 0.83A 1upfC-2yyzA:
undetectable		 1upfC-2yyzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 8 ARG A 203
ALA A 205
GLU A  25
VAL A 188
 None
 0.91A 2bxgA-2yyzA:
undetectable		 2bxgA-2yyzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 207
VAL A  22
ILE A  60
VAL A 154
LEU A  34
 None
 1.20A 2ft9A-2yyzA:
undetectable		 2ft9A-2yyzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A  31
SER A 187
THR A 186
ILE A 204
LEU A 156
 None
 1.39A 3lcvB-2yyzA:
undetectable		 3lcvB-2yyzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 GLY A  39
GLY A  41
THR A  43
 SO4  A1001 (-3.3A)
SO4  A1001 (-3.4A)
SO4  A1001 (-3.4A)
 0.43A 3si7B-2yyzA:
16.1		 3si7B-2yyzA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 ARG A 258
GLU A 317
THR A 316
 None
 0.92A 3v4tA-2yyzA:
undetectable		 3v4tA-2yyzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 6 GLU A 320
ILE A 322
HIS A 348
VAL A 271
 None
 1.20A 4a97I-2yyzA:
undetectable		 4a97I-2yyzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 PRO A  88
MET A  90
TYR A  87
 None
PEG  A2001 ( 4.7A)
PEG  A2001 ( 4.6A)
 1.03A 4qa2B-2yyzA:
3.1		 4qa2B-2yyzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 7 ALA A  85
ARG A 141
GLU A 175
ARG A 146
 None
SO4  A1002 (-2.7A)
None
None
 0.94A 5btdA-2yyzA:
undetectable
5btdB-2yyzA:
undetectable
5btdC-2yyzA:
undetectable		 5btdA-2yyzA:
22.49
5btdB-2yyzA:
21.67
5btdC-2yyzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		4 / 6 ALA A  85
ARG A 141
GLU A 175
ARG A 146
 None
SO4  A1002 (-2.7A)
None
None
 0.93A 5btgA-2yyzA:
undetectable
5btgB-2yyzA:
undetectable
5btgC-2yyzA:
undetectable		 5btgA-2yyzA:
22.49
5btgB-2yyzA:
21.67
5btgC-2yyzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 VAL A 190
SER A 162
MET A 172
 None
 0.91A 5ikqA-2yyzA:
undetectable		 5ikqA-2yyzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		3 / 3 THR A 316
PRO A 342
ARG A 286
 None
 0.84A 5nd7B-2yyzA:
undetectable		 5nd7B-2yyzA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 12 VAL A  22
GLU A 159
VAL A  77
PHE A  24
PHE A 207
 None
 1.29A 6becA-2yyzA:
undetectable
6becB-2yyzA:
undetectable
6becC-2yyzA:
undetectable		 6becA-2yyzA:
21.65
6becB-2yyzA:
21.65
6becC-2yyzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 9 LEU A  35
ILE A 234
PRO A 218
VAL A 221
ILE A 204
 None
 1.28A 6ef6A-2yyzA:
undetectable		 6ef6A-2yyzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermotoga
maritima) 		5 / 11 ILE A 321
THR A 239
ASN A 240
LEU A 242
PHE A 241
 None
 1.45A 6hupA-2yyzA:
undetectable
6hupB-2yyzA:
undetectable		 6hupA-2yyzA:
13.26
6hupB-2yyzA:
11.70