SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yz2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 8 LEU A  23
VAL A  26
VAL A  38
VAL A 209
 None
 0.95A 1iwiA-2yz2A:
undetectable		 1iwiA-2yz2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 8 LEU A  23
VAL A  26
VAL A  38
VAL A 209
 None
 0.89A 1t86A-2yz2A:
undetectable		 1t86A-2yz2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 8 HIS A  10
VAL A   8
LEU A  49
THR A  48
 None
 0.82A 2gehA-2yz2A:
undetectable		 2gehA-2yz2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 4 ASP A 170
LEU A 177
GLY A 173
ARG A 145
 None
 1.38A 2j2pD-2yz2A:
0.0
2j2pE-2yz2A:
0.0		 2j2pD-2yz2A:
20.22
2j2pE-2yz2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 6 LEU A  23
VAL A  26
VAL A  38
VAL A 209
 None
 0.79A 2z97A-2yz2A:
undetectable		 2z97A-2yz2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 8 LEU A  23
VAL A  26
VAL A  38
VAL A 209
 None
 0.83A 2zujA-2yz2A:
undetectable		 2zujA-2yz2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 5 VAL A 208
VAL A 209
THR A 221
ARG A 207
 None
 1.17A 3bjwA-2yz2A:
undetectable		 3bjwA-2yz2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 5 VAL A 208
VAL A 209
THR A 221
ARG A 207
 None
 1.15A 3bjwC-2yz2A:
undetectable		 3bjwC-2yz2A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		5 / 12 ASP A 219
LEU A  28
THR A 190
ILE A 192
LEU A  50
 None
 1.14A 3k2hA-2yz2A:
undetectable		 3k2hA-2yz2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		3 / 3 ARG A  70
LEU A  65
GLU A  69
 None
 0.71A 4l3gF-2yz2A:
undetectable		 4l3gF-2yz2A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 7 ILE A 198
LEU A  37
TYR A 229
GLY A  40
 None
 1.04A 4z69A-2yz2A:
undetectable		 4z69A-2yz2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 8 HIS A  10
VAL A   8
LEU A  49
THR A  48
 None
 0.85A 5tt3F-2yz2A:
undetectable		 5tt3F-2yz2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 8 HIS A  10
VAL A   8
LEU A  49
THR A  48
 None
 0.90A 5tt3H-2yz2A:
undetectable		 5tt3H-2yz2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 7 SER A 140
PHE A 131
VAL A  96
ILE A 149
 None
 1.11A 5vkqA-2yz2A:
undetectable
5vkqB-2yz2A:
undetectable		 5vkqA-2yz2A:
10.16
5vkqB-2yz2A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 8 SER A 140
PHE A 131
VAL A  96
ILE A 149
 None
 1.10A 5vkqB-2yz2A:
undetectable
5vkqC-2yz2A:
undetectable		 5vkqB-2yz2A:
10.16
5vkqC-2yz2A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		4 / 7 SER A 140
PHE A 131
VAL A  96
ILE A 149
 None
 1.07A 5vkqC-2yz2A:
undetectable
5vkqD-2yz2A:
undetectable		 5vkqC-2yz2A:
10.16
5vkqD-2yz2A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2yz2 PUTATIVE ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0222
(Thermotoga
maritima) 		3 / 3 LEU A  28
ASP A  67
ILE A  76
 None
 0.61A 6dh0B-2yz2A:
undetectable		 6dh0B-2yz2A:
16.27