SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yzk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GJ5_A_VD3A164_1 (BETA-LACTOGLOBULIN)	2yzk	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Aeropyrum pernix)	4 / 5	ASP A 46 LEU A 45 MET A 75 ARG A 79	None	1.45A	2gj5A-2yzkA: undetectable	2gj5A-2yzkA: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M7R_A_VDXA425_1 (VITAMIN D3 RECEPTOR)	2yzk	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Aeropyrum pernix)	5 / 12	LEU A 160 LEU A 153 VAL A 158 SER A 125 VAL A 141	None	1.33A	3m7rA-2yzkA: undetectable	3m7rA-2yzkA: 22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_A_ACTA504_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	2yzk	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Aeropyrum pernix)	3 / 3	THR A 117 VAL A 115 GLU A 147	None	0.63A	3v4tA-2yzkA: undetectable 3v4tD-2yzkA: undetectable	3v4tA-2yzkA: 20.53 3v4tD-2yzkA: 20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_A_TLFA601_0 (PROSTAGLANDIN G/H SYNTHASE 2)	2yzk	OROTATE PHOSPHORIBOSYLTRANSF ERASE (Aeropyrum pernix)	5 / 12	VAL A 141 SER A 121 GLY A 148 ALA A 149 LEU A 160	None	1.09A	5iktA-2yzkA: undetectable	5iktA-2yzkA: 15.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2GJ5_A_VD3A164_1","BETA-LACTOGLOBULIN","2yzk","OROTATE PHOSPHORIBOSYLTRANSFERASE","Aeropyrum pernix",4,"ASP A  46;LEU A  45;MET A  75;ARG A  79","None","1.45A","2gj5A-2yzkA:undetectable","2gj5A-2yzkA:21.88"],["3M7R_A_VDXA425_1","VITAMIN D3 RECEPTOR","2yzk","OROTATE PHOSPHORIBOSYLTRANSFERASE","Aeropyrum pernix",5,"LEU A 160;LEU A 153;VAL A 158;SER A 125;VAL A 141","None","1.33A","3m7rA-2yzkA:undetectable","3m7rA-2yzkA:22.13"],["3V4T_A_ACTA504_0","UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE","2yzk","OROTATE PHOSPHORIBOSYLTRANSFERASE","Aeropyrum pernix",3,"THR A 117;VAL A 115;GLU A 147","None","0.63A","3v4tA-2yzkA:undetectable;3v4tD-2yzkA:undetectable","3v4tA-2yzkA:20.53;3v4tD-2yzkA:20.53"],["5IKT_A_TLFA601_0","PROSTAGLANDIN G\/H SYNTHASE 2","2yzk","OROTATE PHOSPHORIBOSYLTRANSFERASE","Aeropyrum pernix",5,"VAL A 141;SER A 121;GLY A 148;ALA A 149;LEU A 160","None","1.09A","5iktA-2yzkA:undetectable","5iktA-2yzkA:15.75"]]