SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 8 GLU A 308
ARG A 311
ARG A 312
GLU A 209
 None
 1.07A 1cmaA-2yzmA:
undetectable
1cmaB-2yzmA:
undetectable		 1cmaA-2yzmA:
16.67
1cmaB-2yzmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 SER A 110
VAL A 107
GLY A 106
GLY A  89
LEU A  98
 None
 1.08A 1fduA-2yzmA:
undetectable		 1fduA-2yzmA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 10 LEU A  53
LEU A  50
ALA A  49
LEU A   5
HIS A  14
 None
 1.30A 1gwrA-2yzmA:
undetectable		 1gwrA-2yzmA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		3 / 3 VAL A  36
ALA A   7
HIS A  82
 None
None
DAL  A 401 (-4.5A)
 0.73A 1q23H-2yzmA:
undetectable		 1q23H-2yzmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 8 GLU A 189
VAL A 131
ARG A 268
GLU A 197
 None
 1.11A 1s3zA-2yzmA:
undetectable
1s3zB-2yzmA:
undetectable		 1s3zA-2yzmA:
21.60
1s3zB-2yzmA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A  80
ALA A   7
LEU A  18
VAL A  16
ILE A  28
 None
 1.12A 1s9pD-2yzmA:
undetectable		 1s9pD-2yzmA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 4 GLY A 288
SER A 293
VAL A  16
LEU A  80
 None
 1.30A 1yajB-2yzmA:
undetectable		 1yajB-2yzmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 4 GLY A   8
SER A  17
ILE A 286
HIS A  82
 None
None
None
DAL  A 401 (-4.5A)
 1.03A 1yajJ-2yzmA:
2.1		 1yajJ-2yzmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 9 LEU A 309
PHE A 299
LEU A 313
LEU A 316
ALA A 267
 None
 1.36A 2bxeA-2yzmA:
undetectable		 2bxeA-2yzmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A 298
LEU A 242
VAL A 250
GLU A 199
LEU A 198
 None
 1.22A 2bxfB-2yzmA:
undetectable		 2bxfB-2yzmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 6 GLU A  60
ALA A  55
PRO A  59
ALA A  57
 None
 1.15A 2zgwB-2yzmA:
undetectable		 2zgwB-2yzmA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 GLY A 106
GLY A  93
LEU A  95
LEU A 313
VAL A  91
 None
 1.05A 3av6A-2yzmA:
undetectable		 3av6A-2yzmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 7 TYR A 258
GLY A 265
VAL A 304
LEU A 255
 None
 0.89A 3elzA-2yzmA:
undetectable		 3elzA-2yzmA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 ALA A   7
LEU A  25
LEU A   5
LEU A   4
LEU A  53
 None
 1.18A 3erdA-2yzmA:
undetectable		 3erdA-2yzmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		3 / 3 TYR A 258
TYR A 295
GLY A 204
 None
 0.67A 3eteB-2yzmA:
2.5
3eteD-2yzmA:
3.1
3eteF-2yzmA:
2.5		 3eteB-2yzmA:
21.00
3eteD-2yzmA:
21.00
3eteF-2yzmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 6 PRO A  59
HIS A  14
LEU A  18
ALA A  55
 None
 1.21A 3gv1A-2yzmA:
undetectable
3gv1C-2yzmA:
undetectable		 3gv1A-2yzmA:
17.41
3gv1C-2yzmA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 ALA A   7
LEU A  25
LEU A   5
LEU A   4
LEU A  53
 None
 1.11A 3hm1A-2yzmA:
undetectable		 3hm1A-2yzmA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 11 GLY A   8
LEU A  34
LEU A  80
LEU A  53
LEU A  18
 None
 1.30A 3ndvA-2yzmA:
undetectable
3ndvB-2yzmA:
undetectable		 3ndvA-2yzmA:
23.32
3ndvB-2yzmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 11 GLY A   8
LEU A  34
LEU A  80
LEU A  53
LEU A  18
 None
 1.29A 3ndvC-2yzmA:
undetectable
3ndvD-2yzmA:
undetectable		 3ndvC-2yzmA:
23.32
3ndvD-2yzmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 11 LEU A  53
LEU A  18
GLY A   8
LEU A  34
LEU A  80
 None
 1.30A 3ndvC-2yzmA:
undetectable
3ndvD-2yzmA:
undetectable		 3ndvC-2yzmA:
23.32
3ndvD-2yzmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 7 ALA A 179
SER A 164
VAL A 166
VAL A 152
LEU A 176
 None
 1.43A 3o14A-2yzmA:
undetectable		 3o14A-2yzmA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 5 LEU A 309
ILE A  28
PRO A  29
PHE A  30
 None
 0.95A 3s3vA-2yzmA:
1.8		 3s3vA-2yzmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A 203
LEU A 283
ALA A 254
ALA A 257
TYR A 258
 None
 1.17A 3vw7A-2yzmA:
undetectable		 3vw7A-2yzmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A 283
TYR A 295
ALA A 254
ALA A 257
TYR A 258
 None
 0.97A 3vw7A-2yzmA:
undetectable		 3vw7A-2yzmA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		3 / 3 ASP A 183
ARG A 137
LYS A 185
 None
 1.21A 3wipG-2yzmA:
undetectable		 3wipG-2yzmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 PHE A 289
PHE A 207
GLY A 265
GLY A 204
ILE A 286
 None
 1.07A 4krhB-2yzmA:
2.5		 4krhB-2yzmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 5 TYR A 102
GLY A  89
ASP A  88
VAL A  16
 None
 1.07A 4nkvD-2yzmA:
undetectable		 4nkvD-2yzmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 11 LEU A  69
ALA A  35
LEU A   4
VAL A  91
LEU A  81
 None
 1.16A 4p65C-2yzmA:
undetectable
4p65D-2yzmA:
undetectable
4p65J-2yzmA:
undetectable
4p65L-2yzmA:
undetectable		 4p65C-2yzmA:
4.38
4p65D-2yzmA:
7.21
4p65J-2yzmA:
7.21
4p65L-2yzmA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 11 LEU A   4
VAL A  91
LEU A  81
LEU A  69
ALA A  35
 None
 1.12A 4p65B-2yzmA:
undetectable
4p65D-2yzmA:
undetectable
4p65G-2yzmA:
undetectable
4p65H-2yzmA:
undetectable		 4p65B-2yzmA:
7.21
4p65D-2yzmA:
7.21
4p65G-2yzmA:
4.38
4p65H-2yzmA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 LEU A  53
LEU A  50
ALA A  49
LEU A   5
GLY A   9
 None
 0.98A 4pxmA-2yzmA:
undetectable		 4pxmA-2yzmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		3 / 3 LYS A 120
ARG A 137
VAL A 136
 None
 0.75A 4x3uA-2yzmA:
undetectable
4x3uB-2yzmA:
undetectable		 4x3uA-2yzmA:
13.57
4x3uB-2yzmA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 GLY A 104
LEU A 203
THR A 285
GLY A 201
PHE A 289
 None
 1.04A 5d4uB-2yzmA:
undetectable		 5d4uB-2yzmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 10 LEU A 237
ALA A 240
GLU A 215
LEU A 198
GLY A 201
 None
 1.30A 5dx3A-2yzmA:
undetectable		 5dx3A-2yzmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 4 VAL A 103
ALA A 105
ILE A 286
THR A 285
 None
 1.15A 5e4dB-2yzmA:
undetectable		 5e4dB-2yzmA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		5 / 12 ILE A 286
HIS A  82
GLY A  86
GLU A 199
ALA A 109
 None
DAL  A 401 (-4.5A)
None
None
None
 1.21A 5ih0A-2yzmA:
undetectable		 5ih0A-2yzmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 5 LYS A 153
GLU A 282
GLY A 158
SER A 160
 None
None
DAL  A 401 ( 4.2A)
None
 0.94A 5jhdJ-2yzmA:
undetectable		 5jhdJ-2yzmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 8 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 1.00A 6mn4A-2yzmA:
undetectable		 6mn4A-2yzmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 8 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 1.20A 6mn4B-2yzmA:
undetectable		 6mn4B-2yzmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 8 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 0.88A 6mn4C-2yzmA:
undetectable		 6mn4C-2yzmA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2yzm D-ALANINE--D-ALANINE
LIGASE
(Thermus
thermophilus) 		4 / 7 HIS A  14
ARG A  42
HIS A  63
ASP A  40
 None
 0.84A 6mn4E-2yzmA:
undetectable		 6mn4E-2yzmA:
23.84