SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		3 / 3 GLU A 253
ILE A 252
ARG A 180
 SAM  A6075 (-3.0A)
SAM  A6075 (-3.6A)
SAM  A6075 (-3.5A)
 0.76A 1cd2A-2yzqA:
undetectable		 1cd2A-2yzqA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 TYR A 131
LEU A 277
MET A 247
PHE A 117
ILE A 112
 None
 1.49A 1xosA-2yzqA:
undetectable		 1xosA-2yzqA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 ALA A  82
VAL A  73
THR A   8
MET A   7
ASP A 111
 None
 1.36A 2qo4A-2yzqA:
undetectable		 2qo4A-2yzqA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		12 / 12 MET A 158
ILE A 172
ASP A 174
THR A 176
ARG A 180
THR A 228
VAL A 231
ILE A 232
ILE A 252
GLU A 253
GLN A 254
PRO A 256
 SAM  A6075 (-4.2A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.4A)
SAM  A6075 (-3.7A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-3.0A)
SAM  A6075 (-4.1A)
SAM  A6075 (-4.6A)
 0.01A 2yzqA-2yzqA:
38.0		 2yzqA-2yzqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 VAL A  73
MET A  86
ILE A  47
VAL A   3
ILE A 112
 None
 1.06A 3frqB-2yzqA:
undetectable		 3frqB-2yzqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 ILE A 106
THR A 108
ASP A 111
THR A   8
PRO A  36
 None
 0.71A 3kpbA-2yzqA:
16.7		 3kpbA-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 ILE A 172
ASP A 174
VAL A 231
ILE A 232
PRO A 256
 SAM  A6075 (-3.9A)
SAM  A6075 (-3.4A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-4.6A)
 1.12A 3kpbA-2yzqA:
16.7		 3kpbA-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		7 / 12 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
PRO A 256
 SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-4.6A)
 0.60A 3kpbA-2yzqA:
16.7		 3kpbA-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 ILE A 106
THR A 108
ASP A 111
THR A   8
PRO A  36
 None
 0.70A 3kpbC-2yzqA:
16.0		 3kpbC-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		7 / 12 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
PRO A 256
 SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-4.6A)
 0.65A 3kpbC-2yzqA:
16.0		 3kpbC-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		6 / 10 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
 SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
 0.63A 3kpbD-2yzqA:
15.8		 3kpbD-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 11 ILE A 106
THR A 108
ASP A 111
THR A   8
PRO A  36
 None
 0.69A 3kpcA-2yzqA:
16.8		 3kpcA-2yzqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		7 / 11 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
PRO A 256
 SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-4.6A)
 0.59A 3kpcA-2yzqA:
16.8		 3kpcA-2yzqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 ILE A 106
THR A 108
ASP A 111
THR A   8
PRO A  36
 None
 0.69A 3kpdB-2yzqA:
15.8		 3kpdB-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		7 / 12 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
PRO A 256
 SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-4.6A)
 0.54A 3kpdB-2yzqA:
15.8		 3kpdB-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		5 / 12 ILE A 106
THR A 108
ASP A 111
THR A   8
PRO A  36
 None
 0.70A 3kpdC-2yzqA:
16.8		 3kpdC-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		7 / 12 ILE A 172
ASP A 177
THR A 228
VAL A 231
ILE A 232
ILE A 252
PRO A 256
 SAM  A6075 (-3.9A)
SAM  A6075 (-2.8A)
SAM  A6075 (-3.5A)
SAM  A6075 (-3.8A)
SAM  A6075 (-3.9A)
SAM  A6075 (-3.6A)
SAM  A6075 (-4.6A)
 0.64A 3kpdC-2yzqA:
16.8		 3kpdC-2yzqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		4 / 5 ARG A  33
LEU A 274
ARG A 114
ILE A   6
 None
 1.27A 3ln1D-2yzqA:
undetectable		 3ln1D-2yzqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780
(Pyrococcus
horikoshii) 		3 / 3 PHE A 271
VAL A 240
ILE A 128
 None
 0.64A 4emaA-2yzqA:
undetectable		 4emaA-2yzqA:
23.81