SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifA-2yzrA:
undetectable		 1kifA-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifB-2yzrA:
undetectable		 1kifB-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifC-2yzrA:
undetectable		 1kifC-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifD-2yzrA:
undetectable		 1kifD-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifE-2yzrA:
undetectable		 1kifE-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifF-2yzrA:
undetectable		 1kifF-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifG-2yzrA:
undetectable		 1kifG-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 1kifH-2yzrA:
undetectable		 1kifH-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.06A 1ve9A-2yzrA:
undetectable		 1ve9A-2yzrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 2du8G-2yzrA:
undetectable		 2du8G-2yzrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 0.96A 2du8J-2yzrA:
undetectable		 2du8J-2yzrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 10 THR A 291
ALA A 290
ALA A 257
VAL A 270
GLY A  37
 None
 1.00A 2f16K-2yzrA:
undetectable
2f16L-2yzrA:
undetectable		 2f16K-2yzrA:
20.73
2f16L-2yzrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 10 THR A 291
ALA A 290
ALA A 257
VAL A 270
GLY A  37
 None
 1.00A 2f16Y-2yzrA:
undetectable
2f16Z-2yzrA:
undetectable		 2f16Y-2yzrA:
20.73
2f16Z-2yzrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 11 ASN A  26
ALA A  38
ILE A  75
VAL A  24
LEU A  65
 None
 1.17A 2h42A-2yzrA:
undetectable		 2h42A-2yzrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 12 ASN A  26
ALA A  38
ILE A  75
VAL A  24
LEU A  65
 None
 1.06A 2h42B-2yzrA:
undetectable		 2h42B-2yzrA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 241
PRO A 242
ARG A 137
 CL  A 507 (-3.9A)
None
CL  A 506 (-3.1A)
 0.49A 2qd4B-2yzrA:
undetectable		 2qd4B-2yzrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 241
PRO A 242
ARG A 137
 CL  A 507 (-3.9A)
None
CL  A 506 (-3.1A)
 0.62A 2qd5A-2yzrA:
undetectable		 2qd5A-2yzrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A 149
ILE A 156
ALA A 128
VAL A 160
LEU A 165
 None
 0.94A 2yqzB-2yzrA:
undetectable		 2yqzB-2yzrA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 249
GLY A 250
GLY A 154
ALA A 159
GLU A 158
 None
 1.17A 4l8fD-2yzrA:
undetectable		 4l8fD-2yzrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 9 TYR A 182
ALA A 189
ARG A 137
ILE A 224
ILE A 225
 None
None
CL  A 506 (-3.1A)
None
None
 1.36A 4oknB-2yzrA:
undetectable		 4oknB-2yzrA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		4 / 7 GLN A 262
LEU A 259
ASP A 256
LEU A 307
 None
 0.95A 5nwvA-2yzrA:
undetectable		 5nwvA-2yzrA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Methanocaldococc
us
jannaschii) 		5 / 11 ARG A 191
PHE A 112
GLN A 108
GLU A 102
THR A  86
 CL  A 506 ( 3.8A)
None
None
None
None
 1.01A 5x19G-2yzrA:
0.0
5x19N-2yzrA:
0.0
5x19O-2yzrA:
0.0		 5x19G-2yzrA:
14.09
5x19N-2yzrA:
20.81
5x19O-2yzrA:
19.47