SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 6 LEU A 289
GLU A 293
THR A 196
TYR A 277
 None
 1.38A 1qvuA-2yzsA:
0.9		 1qvuA-2yzsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 7 SER A 203
ASP A 218
SER A 106
LEU A 297
 None
 0.86A 2cdqB-2yzsA:
undetectable		 2cdqB-2yzsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 7 ALA A 187
TYR A  71
TYR A 186
HIS A  63
 None
 1.30A 2pncA-2yzsA:
undetectable		 2pncA-2yzsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 8 ASP A 229
GLU A 221
SER A 111
LEU A 115
 None
 1.10A 2q0iA-2yzsA:
undetectable		 2q0iA-2yzsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 12 THR A  19
SER A  57
ILE A  39
ASP A  30
ARG A  21
 None
 1.24A 3iv6D-2yzsA:
undetectable		 3iv6D-2yzsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		3 / 3 LYS A 120
ILE A 275
PHE A 276
 None
 0.98A 3j7zS-2yzsA:
undetectable
3j7za-2yzsA:
undetectable		 3j7zS-2yzsA:
15.91
3j7za-2yzsA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 7 LEU A  55
VAL A  41
TYR A   5
LEU A  13
 None
 0.96A 4b3qA-2yzsA:
undetectable		 4b3qA-2yzsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 12 LEU A 271
PHE A  40
PHE A  42
VAL A   4
PHE A  65
 None
 0.86A 4c9wA-2yzsA:
undetectable		 4c9wA-2yzsA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		3 / 3 GLU A 143
ILE A 178
ALA A 220
 None
 0.51A 4wnwB-2yzsA:
undetectable		 4wnwB-2yzsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 8 LEU A 235
PHE A 263
GLY A 181
THR A 185
 None
 0.81A 5eseA-2yzsA:
undetectable		 5eseA-2yzsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		3 / 3 HIS A  10
SER A   9
ARG A 260
 None
 0.92A 5u63A-2yzsA:
undetectable		 5u63A-2yzsA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 6 LEU A 255
PHE A 246
HIS A 245
PHE A  40
 None
 1.08A 5vkqA-2yzsA:
undetectable
5vkqB-2yzsA:
undetectable		 5vkqA-2yzsA:
10.95
5vkqB-2yzsA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		4 / 6 PHE A  40
LEU A 255
PHE A 246
HIS A 245
 None
 1.06A 5vkqA-2yzsA:
undetectable
5vkqD-2yzsA:
undetectable		 5vkqA-2yzsA:
10.95
5vkqD-2yzsA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 10 SER A 209
LEU A 190
SER A 216
LEU A 217
SER A 203
 None
 1.28A 6dlzB-2yzsA:
undetectable
6dlzC-2yzsA:
undetectable		 6dlzB-2yzsA:
12.70
6dlzC-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 11 SER A 203
SER A 209
LEU A 190
SER A 216
LEU A 217
 None
 1.27A 6dlzA-2yzsA:
undetectable
6dlzD-2yzsA:
undetectable		 6dlzA-2yzsA:
12.70
6dlzD-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 10 SER A 209
LEU A 190
SER A 216
LEU A 217
SER A 203
 None
 1.28A 6dm1B-2yzsA:
undetectable
6dm1C-2yzsA:
undetectable		 6dm1B-2yzsA:
12.70
6dm1C-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 11 SER A 203
SER A 209
LEU A 190
SER A 216
LEU A 217
 None
 1.27A 6dm1A-2yzsA:
undetectable
6dm1D-2yzsA:
undetectable		 6dm1A-2yzsA:
12.70
6dm1D-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 10 SER A 209
LEU A 190
SER A 216
LEU A 217
SER A 203
 None
 1.30A 6dm2B-2yzsA:
undetectable
6dm2C-2yzsA:
undetectable		 6dm2B-2yzsA:
12.70
6dm2C-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 10 SER A 203
SER A 209
LEU A 190
SER A 216
LEU A 217
 None
 1.30A 6dm2A-2yzsA:
undetectable
6dm2D-2yzsA:
undetectable		 6dm2A-2yzsA:
12.70
6dm2D-2yzsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Aquifex
aeolicus) 		5 / 12 LEU A 270
GLY A 181
VAL A 228
LEU A 231
ILE A 232
 None
 0.92A 6ecxA-2yzsA:
undetectable		 6ecxA-2yzsA:
22.06