SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 ASP A  58
ASN A 128
GLY A 217
GLY A  25
 GD3  A 502 (-3.1A)
None
None
None
 0.80A 1jr1B-2yzwA:
undetectable		 1jr1B-2yzwA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 5 VAL A 206
GLY A 208
VAL A 205
TRP A 230
 None
 1.10A 1tkqB-2yzwA:
undetectable		 1tkqB-2yzwA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 11 THR A 224
GLY A 127
LEU A 202
ALA A 164
ALA A 167
 None
 0.99A 1x7pA-2yzwA:
undetectable
1x7pB-2yzwA:
undetectable		 1x7pA-2yzwA:
22.26
1x7pB-2yzwA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 ASP A 251
GLY A 223
ALA A 227
ASN A 128
 GD3  A 501 (-2.7A)
None
None
None
 0.82A 2dtjA-2yzwA:
undetectable
2dtjB-2yzwA:
undetectable		 2dtjA-2yzwA:
21.75
2dtjB-2yzwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 8 ARG A 133
GLY A 121
GLY A 125
ALA A 164
ALA A 161
 None
 1.30A 2ej3C-2yzwA:
undetectable		 2ej3C-2yzwA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 7 ALA A 104
THR A 105
ALA A 108
PRO A 130
 None
 0.86A 2ql8A-2yzwA:
undetectable
2ql8B-2yzwA:
undetectable		 2ql8A-2yzwA:
19.27
2ql8B-2yzwA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 11 ARG A 194
LEU A 262
PHE A 232
ALA A 233
GLU A 191
 None
 1.42A 2v0mA-2yzwA:
undetectable		 2v0mA-2yzwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 LEU A 174
ALA A 151
LEU A 148
PHE A 193
 None
 0.78A 2vcvP-2yzwA:
undetectable		 2vcvP-2yzwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 6 ILE A 272
LEU A  50
PHE A  54
MET A  42
 None
 0.99A 3adsA-2yzwA:
undetectable		 3adsA-2yzwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 GLY A  17
GLY A 256
GLY A 260
 None
 0.40A 3bogC-2yzwA:
undetectable		 3bogC-2yzwA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 GLY A 256
GLY A  17
GLY A  21
 None
 0.39A 3bogC-2yzwA:
undetectable		 3bogC-2yzwA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 GLY A 260
GLY A  13
GLY A  17
 None
 0.40A 3bogC-2yzwA:
undetectable		 3bogC-2yzwA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 SER A  60
LEU A  50
ASP A  22
ASP A 253
 None
None
GD3  A 502 ( 4.9A)
GD3  A 501 ( 2.8A)
 1.19A 3n2oC-2yzwA:
undetectable
3n2oD-2yzwA:
undetectable		 3n2oC-2yzwA:
19.25
3n2oD-2yzwA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 11 TYR A 266
GLY A  13
ALA A  14
ILE A 272
ALA A 271
 None
 1.02A 3nmuB-2yzwA:
undetectable
3nmuJ-2yzwA:
undetectable		 3nmuB-2yzwA:
24.43
3nmuJ-2yzwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 5 PHE A  74
ALA A 155
THR A 158
LEU A  65
 None
 1.23A 3t3zC-2yzwA:
undetectable		 3t3zC-2yzwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 12 LEU A 171
GLY A 256
GLY A  25
LEU A 262
GLY A 264
 None
 1.06A 4blvA-2yzwA:
undetectable		 4blvA-2yzwA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 8 ARG A  11
GLY A 270
ALA A 271
ASP A 237
 None
 0.75A 4eyrB-2yzwA:
undetectable		 4eyrB-2yzwA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 12 ALA A 135
GLY A 264
GLY A  13
LEU A 269
GLU A 239
 None
 1.01A 4lg1A-2yzwA:
undetectable		 4lg1A-2yzwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 12 ALA A 135
GLY A 264
GLY A  13
LEU A 269
GLU A 239
 None
 1.07A 4lg1B-2yzwA:
undetectable		 4lg1B-2yzwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 12 HIS A 159
LEU A 165
GLY A 116
ASP A 117
MET A  80
 None
 1.27A 4mubA-2yzwA:
undetectable		 4mubA-2yzwA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 VAL A 206
ALA A 189
PHE A 210
 None
 0.85A 4olbA-2yzwA:
undetectable		 4olbA-2yzwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 GLY A 129
PRO A 130
ALA A 154
 None
 0.52A 4qn9B-2yzwA:
undetectable		 4qn9B-2yzwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 VAL A 206
ALA A 189
PHE A 210
 None
 0.80A 4w5nA-2yzwA:
undetectable		 4w5nA-2yzwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 11 PHE A 238
ALA A 245
VAL A 246
GLY A  17
GLY A 241
 None
 0.92A 4xnxA-2yzwA:
undetectable		 4xnxA-2yzwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 VAL A 206
ALA A 189
PHE A 210
 None
 0.88A 4z4iA-2yzwA:
undetectable		 4z4iA-2yzwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 10 ALA A 135
LEU A  16
ALA A 290
LEU A  65
ALA A  66
 None
 1.14A 4zbrA-2yzwA:
undetectable		 4zbrA-2yzwA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 9 PHE A 238
ILE A 272
GLY A 260
LEU A 175
LEU A 179
 None
 1.32A 4ze0A-2yzwA:
undetectable		 4ze0A-2yzwA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 11 ALA A  14
GLY A 268
LEU A 229
LEU A 171
LEU A 174
 None
 1.14A 4zmeA-2yzwA:
undetectable		 4zmeA-2yzwA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 7 ALA A 263
ASP A  58
GLY A  25
GLU A  29
 None
GD3  A 502 (-3.1A)
None
GD3  A 501 (-3.0A)
 0.84A 5bs8A-2yzwA:
undetectable
5bs8C-2yzwA:
undetectable
5bs8D-2yzwA:
undetectable		 5bs8A-2yzwA:
19.88
5bs8C-2yzwA:
19.88
5bs8D-2yzwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 7 ALA A 263
ASP A  58
GLY A  25
GLU A  29
 None
GD3  A 502 (-3.1A)
None
GD3  A 501 (-3.0A)
 0.85A 5btgA-2yzwA:
undetectable
5btgC-2yzwA:
undetectable
5btgD-2yzwA:
undetectable		 5btgA-2yzwA:
19.88
5btgC-2yzwA:
19.88
5btgD-2yzwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 6 ALA A 167
THR A 168
VAL A 170
VAL A 258
 None
 0.99A 5eckA-2yzwA:
undetectable		 5eckA-2yzwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 6 ALA A 167
THR A 168
VAL A 170
VAL A 258
 None
 0.95A 5eckD-2yzwA:
undetectable		 5eckD-2yzwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 VAL A 206
ALA A 189
PHE A 210
 None
 0.86A 5js1A-2yzwA:
undetectable		 5js1A-2yzwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		3 / 3 LYS A  77
ASP A  75
ARG A 153
 None
 1.01A 5jwaA-2yzwA:
undetectable
5jwaH-2yzwA:
undetectable		 5jwaA-2yzwA:
16.70
5jwaH-2yzwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 12 GLY A 223
ALA A 201
HIS A 199
PRO A 214
THR A 224
 None
 1.22A 5x6yA-2yzwA:
undetectable		 5x6yA-2yzwA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 10 VAL A 255
GLY A 256
ALA A 227
LEU A 248
ASN A 247
 None
 1.09A 5x6yB-2yzwA:
undetectable		 5x6yB-2yzwA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		6 / 12 TYR A 220
GLY A 223
ALA A 201
HIS A 199
PRO A 214
THR A 224
 None
 1.19A 5x6yC-2yzwA:
undetectable		 5x6yC-2yzwA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 7 GLY A 270
GLY A 268
GLY A 264
GLY A 260
GLY A  17
 None
 0.95A 6ag0A-2yzwA:
undetectable		 6ag0A-2yzwA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		5 / 10 VAL A 170
ALA A 167
LEU A 174
LEU A 188
LEU A 190
 None
 0.95A 6f6nA-2yzwA:
undetectable
6f6nB-2yzwA:
undetectable		 6f6nA-2yzwA:
14.98
6f6nB-2yzwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2yzw ADP-RIBOSYLGLYCOHYDR
OLASE
(Thermus
thermophilus) 		4 / 7 ALA A 257
GLY A  21
LEU A  24
GLY A 217
 None
 0.81A 6nm4A-2yzwA:
undetectable		 6nm4A-2yzwA:
21.94