SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QW6_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	3 / 3	ARG A 68 VAL A 89 TRP A 90	None	1.14A	1qw6A-2yzyA: undetectable	1qw6A-2yzyA: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QWC_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	3 / 3	ARG A 68 VAL A 89 TRP A 90	None	1.07A	1qwcA-2yzyA: undetectable	1qwcA-2yzyA: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VAG_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	3 / 3	ARG A 68 VAL A 89 TRP A 90	None	1.09A	1vagA-2yzyA: undetectable	1vagA-2yzyA: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_A_NFZA1219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	4 / 8	TYR A 94 ASN A 80 GLU A 78 GLY A 79	MPD A 503 (-3.8A) None MPD A 503 (-3.6A) MPD A 503 (-3.6A)	1.07A	1ykiA-2yzyA: undetectable 1ykiB-2yzyA: undetectable	1ykiA-2yzyA: 25.00 1ykiB-2yzyA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YKI_B_NFZB2219_1 (OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	4 / 8	TYR A 94 ASN A 80 GLU A 78 GLY A 79	MPD A 503 (-3.8A) None MPD A 503 (-3.6A) MPD A 503 (-3.6A)	1.07A	1ykiA-2yzyA: undetectable 1ykiB-2yzyA: undetectable	1ykiA-2yzyA: 25.00 1ykiB-2yzyA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZVI_A_H4BA901_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	3 / 3	ARG A 68 VAL A 89 TRP A 90	None	1.10A	1zviA-2yzyA: undetectable	1zviA-2yzyA: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS1_B_017B203_1 (HIV-1 PROTEASE)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	4 / 7	GLU A 161 PRO A 140 MET A 143 ARG A 173	MPD A 502 (-3.5A) None None None	1.19A	2hs1B-2yzyA: undetectable	2hs1B-2yzyA: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5FVO_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	2yzy	PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012 (Thermus thermophilus)	3 / 3	ARG A 68 VAL A 89 TRP A 90	None	1.04A	5fvoA-2yzyA: undetectable	5fvoA-2yzyA: 18.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1QW6_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",3,"ARG A  68;VAL A  89;TRP A  90","None","1.14A","1qw6A-2yzyA:undetectable","1qw6A-2yzyA:19.60"],["1QWC_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",3,"ARG A  68;VAL A  89;TRP A  90","None","1.07A","1qwcA-2yzyA:undetectable","1qwcA-2yzyA:19.60"],["1VAG_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",3,"ARG A  68;VAL A  89;TRP A  90","None","1.09A","1vagA-2yzyA:undetectable","1vagA-2yzyA:19.60"],["1YKI_A_NFZA1219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",4,"TYR A  94;ASN A  80;GLU A  78;GLY A  79","MPD A 503 (-3.8A);None;MPD A 503 (-3.6A);MPD A 503 (-3.6A)","1.07A","1ykiA-2yzyA:undetectable;1ykiB-2yzyA:undetectable","1ykiA-2yzyA:25.00;1ykiB-2yzyA:25.00"],["1YKI_B_NFZB2219_1","OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE;OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",4,"TYR A  94;ASN A  80;GLU A  78;GLY A  79","MPD A 503 (-3.8A);None;MPD A 503 (-3.6A);MPD A 503 (-3.6A)","1.07A","1ykiA-2yzyA:undetectable;1ykiB-2yzyA:undetectable","1ykiA-2yzyA:25.00;1ykiB-2yzyA:25.00"],["1ZVI_A_H4BA901_1","NITRIC-OXIDE SYNTHASE, BRAIN","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",3,"ARG A  68;VAL A  89;TRP A  90","None","1.10A","1zviA-2yzyA:undetectable","1zviA-2yzyA:19.60"],["2HS1_B_017B203_1","HIV-1 PROTEASE","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",4,"GLU A 161;PRO A 140;MET A 143;ARG A 173","MPD A 502 (-3.5A);None;None;None","1.19A","2hs1B-2yzyA:undetectable","2hs1B-2yzyA:23.13"],["5FVO_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN","2yzy","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1012","Thermus thermophilus",3,"ARG A  68;VAL A  89;TRP A  90","None","1.04A","5fvoA-2yzyA:undetectable","5fvoA-2yzyA:18.96"]]