SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 10 GLU A 105
ALA A 107
LEU A  69
GLU A  60
GLU A  98
 None
 1.43A 1a29A-2z00A:
undetectable		 1a29A-2z00A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 GLU A 256
THR A 258
HIS A 261
HIS A  57
 None
None
None
ZN  A1004 (-3.4A)
 1.40A 1d4fA-2z00A:
undetectable		 1d4fA-2z00A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 GLU A 256
THR A 258
HIS A 261
HIS A  57
 None
None
None
ZN  A1004 (-3.4A)
 1.36A 1d4fD-2z00A:
undetectable		 1d4fD-2z00A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 HIS A  55
HIS A 174
HIS A 233
ASP A 306
 ZN  A1004 (-3.2A)
ZN  A1006 (-3.2A)
ZN  A1006 (-3.4A)
ZN  A1004 (-2.9A)
 0.59A 1e9yB-2z00A:
21.0		 1e9yB-2z00A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 6 HIS A  55
HIS A  57
HIS A 174
HIS A 233
ASP A 306
 ZN  A1004 (-3.2A)
ZN  A1004 (-3.4A)
ZN  A1006 (-3.2A)
ZN  A1006 (-3.4A)
ZN  A1004 (-2.9A)
 0.63A 1fweC-2z00A:
21.8		 1fweC-2z00A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 12 HIS A 174
THR A 258
ARG A 283
ARG A  59
GLY A 325
 ZN  A1006 (-3.2A)
None
None
None
None
 1.26A 1ia0B-2z00A:
2.6		 1ia0B-2z00A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 12 LEU A 161
LEU A 144
ALA A 139
ALA A 141
VAL A 171
 None
 1.33A 1kt4A-2z00A:
undetectable		 1kt4A-2z00A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 LEU A  58
GLY A  72
VAL A 421
LEU A 110
LEU A 115
 None
 1.16A 1mx1A-2z00A:
undetectable		 1mx1A-2z00A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 6 PHE A 324
ASN A  89
ARG A 181
ASN A 183
 None
 1.45A 1t9uA-2z00A:
undetectable		 1t9uA-2z00A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 12 HIS A 174
THR A 258
ARG A 283
ARG A  59
GLY A 325
 ZN  A1006 (-3.2A)
None
None
None
None
 1.26A 1tubB-2z00A:
1.9		 1tubB-2z00A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 7 GLU A 205
ASN A 200
PRO A 280
ALA A 279
 None
 1.35A 2ejgA-2z00A:
undetectable		 2ejgA-2z00A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 7 GLU A 205
ASN A 200
PRO A 280
ALA A 279
 None
 1.42A 2ejgB-2z00A:
undetectable		 2ejgB-2z00A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 8 SER A 395
THR A 305
PRO A 259
LEU A 336
 None
 1.14A 2v0zO-2z00A:
undetectable		 2v0zO-2z00A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 12 ILE A   2
LEU A   3
ILE A  28
ALA A 376
LEU A  47
 None
 0.95A 3a50D-2z00A:
undetectable		 3a50D-2z00A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 6 VAL A  40
ILE A 420
ILE A   4
LEU A   3
 None
 0.77A 3hegA-2z00A:
undetectable		 3hegA-2z00A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 4 ARG A  59
ASP A  83
GLY A  80
THR A 305
 None
 1.27A 3k4vB-2z00A:
undetectable		 3k4vB-2z00A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 HIS A  55
LEU A  73
LEU A 103
ASP A  68
 ZN  A1004 (-3.2A)
None
None
None
 1.23A 4aqlA-2z00A:
19.6		 4aqlA-2z00A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		3 / 3 HIS A 310
GLU A  63
ASN A  89
 None
 0.93A 4bupB-2z00A:
undetectable		 4bupB-2z00A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 SER A 235
VAL A 231
THR A 236
HIS A 174
VAL A 173
 None
None
None
ZN  A1006 (-3.2A)
None
 1.03A 4e0fA-2z00A:
undetectable		 4e0fA-2z00A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 GLN A 125
ALA A 120
LEU A 121
VAL A 171
LEU A 157
 None
 1.15A 4g1bB-2z00A:
undetectable		 4g1bB-2z00A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 9 THR A 122
GLN A 125
LEU A 121
VAL A 171
LEU A 157
 None
 1.18A 4g1bC-2z00A:
undetectable		 4g1bC-2z00A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 HIS A  55
HIS A 174
HIS A 233
ASP A 306
 ZN  A1004 (-3.2A)
ZN  A1006 (-3.2A)
ZN  A1006 (-3.4A)
ZN  A1004 (-2.9A)
 0.62A 4h9mA-2z00A:
23.4		 4h9mA-2z00A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		3 / 3 ASP A 147
LEU A 143
VAL A 253
 ZN  A1006 ( 2.5A)
None
None
 0.69A 4jecB-2z00A:
undetectable		 4jecB-2z00A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 GLU A 176
ARG A 181
PRO A 280
SER A 235
 None
 1.43A 4k17B-2z00A:
undetectable		 4k17B-2z00A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 ILE A 303
LEU A 354
GLU A 256
VAL A 253
 None
 0.87A 4nkxB-2z00A:
undetectable		 4nkxB-2z00A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 GLY A 418
LEU A 368
ILE A  28
LEU A  47
 None
 0.76A 4o8fA-2z00A:
undetectable		 4o8fA-2z00A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 6 ASP A  83
TYR A  81
LEU A  84
HIS A 116
 None
 1.25A 4paeA-2z00A:
undetectable		 4paeA-2z00A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 HIS A 233
THR A 305
THR A 258
ARG A  59
ALA A 308
 ZN  A1006 (-3.4A)
None
None
None
None
 1.49A 4qvyV-2z00A:
undetectable
4qvyb-2z00A:
undetectable		 4qvyV-2z00A:
19.31
4qvyb-2z00A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 HIS A 233
THR A 305
THR A 258
ARG A  59
ALA A 308
 ZN  A1006 (-3.4A)
None
None
None
None
 1.49A 4qvyH-2z00A:
undetectable
4qvyN-2z00A:
undetectable		 4qvyH-2z00A:
19.31
4qvyN-2z00A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 6 HIS A  55
HIS A  57
HIS A 174
HIS A 233
ASP A 306
 ZN  A1004 (-3.2A)
ZN  A1004 (-3.4A)
ZN  A1006 (-3.2A)
ZN  A1006 (-3.4A)
ZN  A1004 (-2.9A)
 0.51A 4ubpC-2z00A:
22.5		 4ubpC-2z00A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 LEU A 291
GLU A 289
LEU A 336
HIS A 260
 None
 1.32A 4xi3B-2z00A:
undetectable		 4xi3B-2z00A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 12 LEU A 351
PHE A  46
PHE A 333
GLY A 409
THR A 258
 None
 1.00A 4ze1A-2z00A:
undetectable		 4ze1A-2z00A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 12 LEU A 351
PHE A  46
PHE A 333
GLY A 409
THR A 258
 None
 1.10A 4ze2A-2z00A:
undetectable		 4ze2A-2z00A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 HIS A 233
THR A 305
THR A 258
ARG A  59
ALA A 308
 ZN  A1006 (-3.4A)
None
None
None
None
 1.48A 5bxnV-2z00A:
undetectable
5bxnb-2z00A:
undetectable		 5bxnV-2z00A:
19.31
5bxnb-2z00A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 HIS A 233
THR A 305
THR A 258
ARG A  59
ALA A 308
 ZN  A1006 (-3.4A)
None
None
None
None
 1.47A 5bxnH-2z00A:
undetectable
5bxnN-2z00A:
undetectable		 5bxnH-2z00A:
19.31
5bxnN-2z00A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 6 PRO A 309
ALA A 107
LEU A 115
TYR A  81
 None
 1.05A 5igiA-2z00A:
undetectable		 5igiA-2z00A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 HIS A 233
THR A 305
THR A 258
ARG A  59
ALA A 308
 ZN  A1006 (-3.4A)
None
None
None
None
 1.50A 5l5fV-2z00A:
undetectable
5l5fb-2z00A:
0.0		 5l5fV-2z00A:
19.31
5l5fb-2z00A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 HIS A 233
THR A 305
THR A 258
ARG A  59
ALA A 308
 ZN  A1006 (-3.4A)
None
None
None
None
 1.50A 5l5fH-2z00A:
undetectable
5l5fN-2z00A:
undetectable		 5l5fH-2z00A:
19.31
5l5fN-2z00A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 8 ASP A 306
HIS A  57
ARG A 181
HIS A 233
 ZN  A1004 (-2.9A)
ZN  A1004 (-3.4A)
None
ZN  A1006 (-3.4A)
 0.91A 5nekD-2z00A:
undetectable		 5nekD-2z00A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		3 / 3 PHE A  51
ASP A  53
LEU A 110
 None
 0.78A 5uhbC-2z00A:
undetectable		 5uhbC-2z00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		3 / 3 PHE A  51
ASP A  53
LEU A 110
 None
 0.70A 5uhcC-2z00A:
undetectable		 5uhcC-2z00A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		3 / 3 ILE A 326
VAL A 278
PRO A 280
 None
 0.62A 5uunA-2z00A:
undetectable		 5uunA-2z00A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		3 / 3 HIS A 310
GLU A  63
ASN A  89
 None
 1.02A 5wbvB-2z00A:
undetectable		 5wbvB-2z00A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 12 VAL A  94
LEU A  73
LEU A  58
LEU A  84
GLY A 140
 None
 0.75A 6b0cD-2z00A:
undetectable		 6b0cD-2z00A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		4 / 5 THR A 258
HIS A  55
ASP A 147
HIS A  57
 None
ZN  A1004 (-3.2A)
ZN  A1006 ( 2.5A)
ZN  A1004 (-3.4A)
 1.16A 6dchA-2z00A:
undetectable		 6dchA-2z00A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2z00 DIHYDROOROTASE
(Thermus
thermophilus) 		5 / 11 LEU A 413
THR A 414
SER A 377
GLY A  50
ILE A  23
 None
 1.03A 6ebzC-2z00A:
undetectable		 6ebzC-2z00A:
10.49