SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 8 LEU A 178
ARG A 267
VAL A 338
ALA A 333
 None
 0.91A 1fiqC-2z01A:
undetectable		 1fiqC-2z01A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 10 GLU A 200
LEU A 217
LYS A  69
LEU A  73
LEU A  74
 None
 1.37A 1ie4A-2z01A:
undetectable
1ie4C-2z01A:
undetectable		 1ie4A-2z01A:
18.55
1ie4C-2z01A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 10 LYS A  69
LEU A  73
LEU A  74
GLU A 200
LEU A 217
 None
 1.35A 1ie4A-2z01A:
undetectable
1ie4C-2z01A:
undetectable		 1ie4A-2z01A:
18.55
1ie4C-2z01A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 9 GLY A  81
GLY A  65
LEU A  68
SER A 188
GLY A  63
 None
 1.16A 1l5lA-2z01A:
undetectable		 1l5lA-2z01A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 9 GLY A  81
GLY A  65
LEU A  68
SER A 188
GLY A  63
 None
 1.16A 1l5mA-2z01A:
undetectable		 1l5mA-2z01A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 5 LEU A 153
VAL A 123
ALA A 130
CYH A 127
 None
 1.17A 1mz9D-2z01A:
undetectable		 1mz9D-2z01A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.56A 1q23C-2z01A:
undetectable		 1q23C-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.52A 1q23H-2z01A:
undetectable		 1q23H-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.60A 1q23G-2z01A:
undetectable		 1q23G-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.65A 1q23L-2z01A:
undetectable		 1q23L-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		3 / 3 VAL A  85
ALA A  86
HIS A 187
 None
 0.53A 1q23J-2z01A:
undetectable		 1q23J-2z01A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 6 TRP A 273
ASN A 298
LEU A 252
PHE A 294
 None
 1.32A 1ru9H-2z01A:
undetectable
1ru9L-2z01A:
undetectable		 1ru9H-2z01A:
18.93
1ru9L-2z01A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 6 TRP A 273
ASN A 298
LEU A 252
PHE A 294
 None
 1.29A 1rukH-2z01A:
undetectable
1rukL-2z01A:
undetectable		 1rukH-2z01A:
18.93
1rukL-2z01A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 4 LEU A  68
ILE A 119
ILE A 106
ALA A 107
 None
 0.87A 2i30A-2z01A:
undetectable		 2i30A-2z01A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 11 VAL A  26
LEU A 134
THR A 139
ASP A 104
VAL A 120
 None
 1.07A 2z9xB-2z01A:
undetectable		 2z9xB-2z01A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 8 LEU A 178
ARG A 267
VAL A 338
ALA A 333
 None
 0.96A 3ax9A-2z01A:
undetectable		 3ax9A-2z01A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 11 LEU A 303
ILE A  93
PHE A 102
ASP A  83
SER A 188
 None
 1.34A 3ko0C-2z01A:
undetectable
3ko0D-2z01A:
undetectable
3ko0E-2z01A:
0.0
3ko0F-2z01A:
undetectable		 3ko0C-2z01A:
13.17
3ko0D-2z01A:
13.17
3ko0E-2z01A:
13.17
3ko0F-2z01A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 5 LEU A  57
ARG A  31
ILE A 135
PHE A 101
 None
 1.18A 3ln1D-2z01A:
undetectable		 3ln1D-2z01A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  96
GLY A 243
LEU A 305
ALA A 229
HIS A 246
 None
 1.03A 3ou6B-2z01A:
undetectable		 3ou6B-2z01A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A  96
GLY A 243
LEU A 305
ALA A 229
HIS A 246
 None
 1.06A 3ou7B-2z01A:
undetectable		 3ou7B-2z01A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A 306
LEU A 305
LEU A 319
ILE A 264
GLY A 175
 None
 1.07A 3ozwB-2z01A:
undetectable		 3ozwB-2z01A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 10 LEU A  74
LEU A 206
GLY A 218
VAL A 194
VAL A 198
 None
 1.29A 4c9nB-2z01A:
undetectable		 4c9nB-2z01A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 8 VAL A 194
TYR A 191
LEU A  74
LEU A 206
 None
 1.03A 4jtrA-2z01A:
undetectable		 4jtrA-2z01A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 6 SER A 184
GLY A 126
ASP A 125
GLY A  81
 None
 1.04A 4koeA-2z01A:
1.2
4koeB-2z01A:
1.2
4koeC-2z01A:
undetectable		 4koeA-2z01A:
22.90
4koeB-2z01A:
22.90
4koeC-2z01A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 9 ARG A  53
GLY A  51
LEU A  47
PRO A  55
VAL A 160
 None
 1.30A 4mjrA-2z01A:
undetectable		 4mjrA-2z01A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 12 PHE A 199
ILE A 278
LEU A  70
LEU A 206
LEU A 217
 None
 1.00A 4xumA-2z01A:
undetectable		 4xumA-2z01A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 6 GLY A 126
ASP A 125
GLY A  81
SER A 184
 None
 1.03A 4z53A-2z01A:
undetectable
4z53B-2z01A:
undetectable		 4z53A-2z01A:
19.48
4z53B-2z01A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		4 / 7 GLY A 137
VAL A 123
ILE A 119
VAL A 120
 None
 0.66A 5ik1A-2z01A:
undetectable		 5ik1A-2z01A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 10 ILE A 241
ILE A 167
MET A 244
VAL A 235
ILE A  93
 None
 1.35A 5mzrA-2z01A:
undetectable		 5mzrA-2z01A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 10 ILE A 241
ILE A 167
MET A 244
VAL A 235
ILE A  93
 None
 1.38A 5mzrC-2z01A:
undetectable		 5mzrC-2z01A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE
(Geobacillus
kaustophilus) 		5 / 9 ILE A 241
ILE A 167
MET A 244
VAL A 235
ILE A  93
 None
 1.35A 5mzrD-2z01A:
undetectable		 5mzrD-2z01A:
13.43