SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A 167
LEU A 168
PHE A 172
MET A 205
 None
 1.10A 1x8vA-2z02A:
undetectable		 1x8vA-2z02A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 195
HIS A  75
LYS A  88
 None
ATP  A1527 (-4.1A)
None
 1.12A 1y7iA-2z02A:
undetectable		 1y7iA-2z02A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A  75
VAL A 164
LEU A 241
LEU A 168
 ATP  A1527 (-4.1A)
None
None
None
 0.93A 3kk6A-2z02A:
undetectable		 3kk6A-2z02A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  53
GLY A  51
GLU A  33
ALA A  57
TYR A  79
 None
 1.37A 3t7sC-2z02A:
undetectable		 3t7sC-2z02A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 138
LEU A 148
ILE A 186
ILE A 184
GLU A 153
 None
 1.29A 3tmzA-2z02A:
undetectable		 3tmzA-2z02A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  34
SER A 201
SER A  60
 None
 0.88A 3ufgB-2z02A:
undetectable		 3ufgB-2z02A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 217
ARG A 206
ASP A 214
 None
SO4  A 512 (-3.1A)
None
 0.78A 4fp9A-2z02A:
undetectable		 4fp9A-2z02A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 217
ARG A 206
ASP A 214
 None
SO4  A 512 (-3.1A)
None
 0.82A 4fp9C-2z02A:
undetectable		 4fp9C-2z02A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 217
ARG A 206
ASP A 214
 None
SO4  A 512 (-3.1A)
None
 0.80A 4fp9F-2z02A:
undetectable		 4fp9F-2z02A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  19
GLY A  53
ILE A  86
ALA A  87
GLU A 185
 ATP  A1527 (-4.0A)
None
None
ATP  A1527 ( 4.3A)
ATP  A1527 (-3.4A)
 1.11A 4r29D-2z02A:
undetectable		 4r29D-2z02A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 4 SER A  60
ASP A 198
ASP A 135
ASP A 203
 None
ATP  A1527 (-4.3A)
None
None
 1.40A 4uciA-2z02A:
undetectable		 4uciA-2z02A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 5 GLU A 199
LYS A  20
ASP A 198
GLU A 185
 None
ATP  A1527 (-2.7A)
ATP  A1527 (-4.3A)
ATP  A1527 (-3.4A)
 1.38A 5a06A-2z02A:
undetectable		 5a06A-2z02A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 4 LEU A  63
ILE A 200
PRO A 202
LEU A 207
 None
 1.17A 5eb3A-2z02A:
undetectable		 5eb3A-2z02A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2z02 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  22
ILE A  92
HIS A  75
VAL A  30
PHE A  34
 ATP  A1527 (-4.4A)
ATP  A1527 (-3.7A)
ATP  A1527 (-4.1A)
None
None
 1.31A 6j21A-2z02A:
undetectable		 6j21A-2z02A:
18.97