SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		4 / 8 LEU A 224
PHE A 234
VAL A  89
ALA A 252
 None
 0.91A 1fiqC-2z04A:
undetectable		 1fiqC-2z04A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		5 / 12 GLU A  66
ILE A 180
GLN A 270
ARG A 254
GLU A 237
 None
 1.45A 1ki7B-2z04A:
undetectable		 1ki7B-2z04A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		4 / 8 ASN A 335
LEU A 263
ASP A 264
GLU A  19
 None
 1.18A 1mxgA-2z04A:
undetectable		 1mxgA-2z04A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJY_H_BEZH306_0
(ANTIBODY 7A1 FAB')		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		4 / 4 ASN A 273
ALA A 277
ARG A 276
TYR A 190
 None
 1.37A 2ajyH-2z04A:
3.0		 2ajyH-2z04A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AK1_H_BEZH401_0
(ANTIBODY 7A1 FAB')		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		4 / 4 ASN A 273
ALA A 277
ARG A 276
TYR A 190
 None
 1.43A 2ak1H-2z04A:
3.0		 2ak1H-2z04A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		5 / 12 ALA A 252
THR A 235
ALA A 277
ILE A 230
LEU A  80
 None
 0.98A 2nyrA-2z04A:
4.9		 2nyrA-2z04A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		4 / 8 LEU A 224
PHE A 234
VAL A  89
ALA A 252
 None
 0.88A 3ax9A-2z04A:
3.8		 3ax9A-2z04A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		5 / 9 PHE A 234
VAL A 233
GLY A 232
VAL A 236
GLY A 181
 None
 1.35A 3kmoA-2z04A:
undetectable		 3kmoA-2z04A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		4 / 8 ASP A  56
GLY A   5
ILE A   6
VAL A  72
 None
 0.61A 3nu9A-2z04A:
undetectable		 3nu9A-2z04A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT
(Aquifex
aeolicus) 		4 / 5 ALA A 277
THR A 279
VAL A   4
ILE A  60
 None
 0.90A 4xe3A-2z04A:
undetectable		 4xe3A-2z04A:
19.47