SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 10 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.30A 1fk9A-2z06A:
undetectable		 1fk9A-2z06A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 12 ILE A   6
GLY A  14
VAL A  18
ALA A 222
GLY A  36
 None
 1.11A 1kiaB-2z06A:
undetectable		 1kiaB-2z06A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 12 ILE A   6
GLY A  14
VAL A  18
ALA A 222
GLY A  36
 None
 1.12A 1kiaC-2z06A:
undetectable		 1kiaC-2z06A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 10 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.35A 1lw0A-2z06A:
undetectable		 1lw0A-2z06A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 11 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.32A 1lwcA-2z06A:
undetectable		 1lwcA-2z06A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 11 VAL A 235
ALA A 165
ALA A 178
ASP A 160
PRO A 241
 None
None
None
CO  A 307 (-3.8A)
None
 1.33A 2admB-2z06A:
undetectable		 2admB-2z06A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 10 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.31A 2hndA-2z06A:
undetectable		 2hndA-2z06A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 10 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.32A 2hnyA-2z06A:
undetectable		 2hnyA-2z06A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 10 SER A  49
ASN A  38
GLY A 202
ALA A 222
GLN A 224
 None
 1.49A 2x2iB-2z06A:
undetectable		 2x2iB-2z06A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 12 ALA A  40
SER A  62
PRO A  85
LEU A  77
PRO A  93
 None
 1.26A 3cl9A-2z06A:
undetectable		 3cl9A-2z06A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 9 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.35A 3lp0A-2z06A:
undetectable		 3lp0A-2z06A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 10 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.29A 3lp1A-2z06A:
undetectable		 3lp1A-2z06A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 10 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.31A 3qipA-2z06A:
undetectable		 3qipA-2z06A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		3 / 4 SER A 199
GLY A 192
GLU A 143
 None
 0.68A 3raeA-2z06A:
undetectable
3raeC-2z06A:
undetectable		 3raeA-2z06A:
17.92
3raeC-2z06A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		4 / 7 ALA A 231
PHE A 229
ALA A  34
LEU A   4
 None
 0.94A 4du2A-2z06A:
undetectable		 4du2A-2z06A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 12 GLN A 224
ALA A 222
ASP A   8
MET A  10
GLY A 195
 None
 1.35A 4j7xA-2z06A:
2.7		 4j7xA-2z06A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 12 LEU A  86
VAL A 112
VAL A 140
VAL A 144
LEU A 159
 None
 0.91A 4m2vA-2z06A:
undetectable		 4m2vA-2z06A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		4 / 8 LEU A 128
VAL A 166
VAL A 140
LEU A 155
 None
 1.06A 4pwdC-2z06A:
undetectable		 4pwdC-2z06A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		4 / 8 LEU A 128
VAL A 166
VAL A 140
LEU A 155
 None
 1.11A 4q0bA-2z06A:
undetectable		 4q0bA-2z06A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 11 LEU A   4
VAL A 191
TYR A 247
GLY A   7
LEU A  22
 None
 1.22A 5hbmA-2z06A:
undetectable		 5hbmA-2z06A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		4 / 7 VAL A   9
ILE A   6
VAL A  61
ALA A  34
 None
 0.71A 5ospA-2z06A:
undetectable		 5ospA-2z06A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		4 / 7 VAL A   9
ILE A   6
VAL A  61
ALA A  34
 None
 0.72A 5osrA-2z06A:
undetectable		 5osrA-2z06A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		4 / 7 ASN A  65
HIS A  66
GLY A 202
ASN A  38
 CO  A 253 (-2.5A)
None
None
None
 0.73A 5x7pA-2z06A:
undetectable		 5x7pA-2z06A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		5 / 11 ALA A  34
VAL A  32
ILE A  25
ALA A  17
LEU A  22
 None
 1.23A 6h1lB-2z06A:
undetectable		 6h1lB-2z06A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625
(Thermus
thermophilus) 		4 / 7 GLY A 192
HIS A  66
ASN A  38
GLY A 202
 None
 0.93A 6n7fA-2z06A:
undetectable		 6n7fA-2z06A:
14.96