SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z0b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5
(Homo
sapiens) 		4 / 7 LEU A  79
PRO A  47
VAL A  24
TRP A  57
 None
 1.33A 2hrcA-2z0bA:
undetectable		 2hrcA-2z0bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5
(Homo
sapiens) 		3 / 3 LEU A  34
TYR A  71
GLN A  70
 None
 0.74A 2wekA-2z0bA:
undetectable		 2wekA-2z0bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5
(Homo
sapiens) 		4 / 5 ARG A  16
ASP A 114
ILE A 112
GLU A  53
 None
 1.39A 2xrzA-2z0bA:
undetectable
2xrzB-2z0bA:
undetectable		 2xrzA-2z0bA:
14.35
2xrzB-2z0bA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5
(Homo
sapiens) 		4 / 5 PHE A  74
ILE A  15
ASN A  36
PHE A  25
 None
 0.99A 3octA-2z0bA:
undetectable		 3octA-2z0bA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5
(Homo
sapiens) 		5 / 11 ILE A  27
ASP A 115
PHE A  13
SER A  68
LEU A  34
 None
 1.28A 3qg2B-2z0bA:
undetectable		 3qg2B-2z0bA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5
(Homo
sapiens) 		4 / 7 GLU A  53
GLU A  48
GLU A  14
ARG A  16
 None
 1.02A 4mi4B-2z0bA:
undetectable
4mi4C-2z0bA:
undetectable		 4mi4B-2z0bA:
19.19
4mi4C-2z0bA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2z0b PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
5
(Homo
sapiens) 		4 / 8 GLU A  53
GLU A  48
GLU A  14
ARG A  16
 None
 1.02A 4mj8B-2z0bA:
undetectable
4mj8C-2z0bA:
undetectable		 4mj8B-2z0bA:
18.58
4mj8C-2z0bA:
18.58