SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 ALA A 308
LEU A 416
LEU A 397
ALA A 398
LEU A 314
 None
 1.28A 1g5yB-2z0fA:
undetectable		 1g5yB-2z0fA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 8 GLU A 348
VAL A 346
GLU A 500
ASP A 336
 None
 1.22A 1s3zA-2z0fA:
undetectable
1s3zB-2z0fA:
undetectable		 1s3zA-2z0fA:
13.00
1s3zB-2z0fA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 4 THR A 387
GLY A 382
ASP A 381
ALA A 200
 None
 1.20A 1sg9A-2z0fA:
undetectable		 1sg9A-2z0fA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		3 / 3 HIS A 292
ASP A 288
ASN A 132
 None
 0.82A 1wg8B-2z0fA:
undetectable		 1wg8B-2z0fA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 9 ARG A 155
GLY A  23
VAL A  24
GLU A 158
GLU A 159
 None
 1.48A 1z37A-2z0fA:
undetectable		 1z37A-2z0fA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 9 PHE A  26
LEU A 126
VAL A 125
GLY A 124
ILE A 157
 None
 1.19A 2a1oB-2z0fA:
undetectable		 2a1oB-2z0fA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 PRO A  77
PHE A  40
ALA A  82
THR A  81
TYR A  10
 None
 1.18A 2axnA-2z0fA:
undetectable		 2axnA-2z0fA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 11 LEU A 169
TYR A  10
VAL A  24
GLY A  23
ALA A 161
 None
 1.10A 2bxgA-2z0fA:
undetectable		 2bxgA-2z0fA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 TYR A 413
ALA A 398
ALA A 309
GLY A 293
GLY A 395
 None
 1.00A 2igtA-2z0fA:
2.1		 2igtA-2z0fA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 TYR A 413
ALA A 398
ALA A 309
GLY A 293
GLY A 395
 None
 1.02A 2igtB-2z0fA:
undetectable		 2igtB-2z0fA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 8 ASN A 115
ILE A 111
ASP A 123
ARG A  56
 None
 1.07A 2v57A-2z0fA:
undetectable		 2v57A-2z0fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 8 ASN A 115
ILE A 111
ASP A 123
ARG A  56
 None
 1.07A 2v57C-2z0fA:
undetectable		 2v57C-2z0fA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 8 SER A 108
GLY A 382
ALA A 323
PHE A 367
 None
 0.96A 3aodA-2z0fA:
undetectable		 3aodA-2z0fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 7 VAL A  45
TYR A  10
GLU A  76
PRO A  77
 None
 1.08A 3hs4A-2z0fA:
undetectable		 3hs4A-2z0fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 8 GLU A 418
GLU A 414
LEU A 334
PHE A 502
 None
 1.11A 3rqwF-2z0fA:
undetectable
3rqwJ-2z0fA:
undetectable		 3rqwF-2z0fA:
19.88
3rqwJ-2z0fA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 LEU A 335
PHE A 377
THR A 316
THR A 317
LEU A 412
 None
 1.08A 3sp9A-2z0fA:
undetectable		 3sp9A-2z0fA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 LEU A 335
PHE A 377
THR A 316
THR A 317
LEU A 412
 None
 1.07A 3sp9B-2z0fA:
undetectable		 3sp9B-2z0fA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 VAL A 458
GLY A 504
SER A 501
ALA A 499
ALA A 426
 None
 1.08A 3sueC-2z0fA:
undetectable		 3sueC-2z0fA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 5 LEU A 307
ILE A 294
ALA A 310
MET A 301
 None
 1.07A 4dc3B-2z0fA:
undetectable		 4dc3B-2z0fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		3 / 3 PRO A 471
ASN A 468
HIS A 355
 None
 1.03A 4ma3H-2z0fA:
undetectable
4ma3L-2z0fA:
undetectable		 4ma3H-2z0fA:
16.31
4ma3L-2z0fA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		3 / 3 PRO A 488
VAL A 351
HIS A 355
 None
 0.82A 4pevC-2z0fA:
3.4		 4pevC-2z0fA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 11 GLY A 299
PHE A 279
ASP A 280
ILE A 213
ASP A 277
 None
 1.48A 4rtrA-2z0fA:
undetectable		 4rtrA-2z0fA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 7 ILE A  48
ARG A  32
THR A 128
LEU A 127
 None
 0.96A 5b1aA-2z0fA:
undetectable
5b1aJ-2z0fA:
undetectable		 5b1aA-2z0fA:
24.11
5b1aJ-2z0fA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 7 ILE A  48
ARG A  32
THR A 128
LEU A 127
 None
 0.96A 5b3sA-2z0fA:
undetectable
5b3sJ-2z0fA:
undetectable		 5b3sA-2z0fA:
24.11
5b3sJ-2z0fA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 GLU A 370
HIS A 292
ALA A 375
PHE A 367
LEU A 335
 None
 1.21A 5nd2B-2z0fA:
undetectable		 5nd2B-2z0fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 7 LEU A  74
TRP A  79
ALA A  80
LEU A  83
 None
 1.01A 5nwvA-2z0fA:
undetectable		 5nwvA-2z0fA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 SER A  29
GLU A 370
GLY A 352
VAL A 351
ARG A 487
 None
 1.29A 5o4yD-2z0fA:
undetectable
5o4yE-2z0fA:
undetectable		 5o4yD-2z0fA:
3.86
5o4yE-2z0fA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 5 LEU A 416
LEU A 334
MET A 301
GLN A 407
 None
 1.21A 5uc3A-2z0fA:
undetectable		 5uc3A-2z0fA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 7 ILE A  48
ARG A  32
THR A 128
LEU A 127
 None
 0.93A 5zcpA-2z0fA:
0.4
5zcpJ-2z0fA:
undetectable		 5zcpA-2z0fA:
24.11
5zcpJ-2z0fA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		4 / 7 ILE A  48
ARG A  32
THR A 128
LEU A 127
 None
 0.97A 5zcqA-2z0fA:
undetectable
5zcqJ-2z0fA:
undetectable		 5zcqA-2z0fA:
24.11
5zcqJ-2z0fA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 GLY A  63
ILE A 157
GLY A 124
PHE A  86
ALA A  53
 None
 1.07A 6c2mB-2z0fA:
undetectable		 6c2mB-2z0fA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		5 / 12 GLY A  63
ILE A 157
GLY A 124
PHE A  86
ALA A  53
 None
 1.06A 6c2mD-2z0fA:
undetectable		 6c2mD-2z0fA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z0f PUTATIVE
PHOSPHOGLUCOMUTASE
(Thermus
thermophilus) 		3 / 3 LEU A  67
GLY A 124
PHE A  26
 None
 0.64A 6exiC-2z0fA:
undetectable		 6exiC-2z0fA:
9.35