SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		5 / 12 ILE A  59
ALA A 250
GLN A  25
ILE A 257
PRO A 258
 None
CL  A 509 ( 4.3A)
None
None
None
 1.03A 1drfA-2z0lA:
undetectable		 1drfA-2z0lA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		5 / 12 ILE A  59
GLN A  25
SER A 261
ILE A 257
PRO A 258
 None
 0.96A 1drfA-2z0lA:
undetectable		 1drfA-2z0lA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		4 / 4 SER A 261
GLY A 278
HIS A  27
ASP A 246
 None
 1.27A 2oxtC-2z0lA:
undetectable		 2oxtC-2z0lA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		4 / 6 SER A 291
ARG A 266
ILE A 272
PHE A 295
 None
 1.17A 2q72A-2z0lA:
undetectable		 2q72A-2z0lA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		4 / 6 SER A 291
ARG A 266
ILE A 272
PHE A 295
 None
 1.18A 2qeiA-2z0lA:
undetectable		 2qeiA-2z0lA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		5 / 12 SER A 247
VAL A 243
THR A 198
PHE A 267
ILE A 273
 None
 1.15A 2vdyB-2z0lA:
undetectable		 2vdyB-2z0lA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		5 / 12 LEU A  14
PHE A   9
VAL A  63
PHE A  86
GLY A  30
 None
 1.35A 5f9zB-2z0lA:
undetectable		 5f9zB-2z0lA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z0l EARLY ANTIGEN
PROTEIN D
(Human
gammaherpesvirus
4) 		4 / 6 VAL A 226
LEU A 265
ILE A 273
PHE A 267
 None
 0.95A 5jw1A-2z0lA:
undetectable		 5jw1A-2z0lA:
21.08