SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A  43
ALA A 190
THR A  18
THR A  24
 None
 0.92A 1c9sT-2z0mA:
undetectable
1c9sU-2z0mA:
undetectable		 1c9sT-2z0mA:
13.55
1c9sU-2z0mA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A 236
ALA A 243
GLY A 222
VAL A 227
ILE A 271
 None
 0.98A 1sduA-2z0mA:
undetectable		 1sduA-2z0mA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 9 LEU A  60
VAL A  61
THR A  63
ILE A  76
VAL A  72
 None
 1.39A 2l8mA-2z0mA:
undetectable		 2l8mA-2z0mA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 12 THR A  69
PHE A 130
SER A  59
ILE A 153
LEU A 116
 None
 1.20A 3iv6A-2z0mA:
3.6		 3iv6A-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A  70
THR A  69
PHE A 130
ILE A 153
LEU A 116
 None
 1.18A 3iv6C-2z0mA:
3.0		 3iv6C-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 12 THR A  69
PHE A 130
SER A  59
ILE A 153
LEU A 116
 None
 1.25A 3iv6C-2z0mA:
3.0		 3iv6C-2z0mA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		3 / 3 GLY A  41
GLY A  43
THR A  45
 None
 0.44A 3si7B-2z0mA:
3.3		 3si7B-2z0mA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 7 VAL A 103
ILE A 125
THR A 112
THR A  63
 None
 1.05A 3tneB-2z0mA:
undetectable		 3tneB-2z0mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 7 ALA A 111
ARG A  70
ALA A  73
ARG A  77
 None
 1.09A 3twpB-2z0mA:
undetectable		 3twpB-2z0mA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 7 ALA A 111
ARG A  70
ALA A  73
ARG A  77
 None
 1.01A 3twpC-2z0mA:
undetectable		 3twpC-2z0mA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		3 / 3 THR A  63
VAL A  61
GLU A 137
 None
 0.68A 3v4tA-2z0mA:
1.6
3v4tD-2z0mA:
1.6		 3v4tA-2z0mA:
24.31
3v4tD-2z0mA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 8 PRO A 251
SER A 253
VAL A 254
ARG A 257
 None
 0.90A 4mk4A-2z0mA:
2.8		 4mk4A-2z0mA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A 125
ARG A 160
SER A 158
ILE A 153
 None
 0.98A 4xtaB-2z0mA:
undetectable		 4xtaB-2z0mA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 8 THR A  24
GLY A  43
ALA A 190
THR A  18
 None
 0.90A 5eevL-2z0mA:
undetectable
5eevV-2z0mA:
undetectable		 5eevL-2z0mA:
13.55
5eevV-2z0mA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 8 THR A  24
GLY A  43
ALA A 190
THR A  18
 None
 0.90A 5eewL-2z0mA:
undetectable
5eewV-2z0mA:
undetectable		 5eewL-2z0mA:
13.55
5eewV-2z0mA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 8 THR A  24
GLY A  43
ALA A 190
THR A  18
 None
 0.90A 5ef3L-2z0mA:
undetectable
5ef3V-2z0mA:
undetectable		 5ef3L-2z0mA:
13.55
5ef3V-2z0mA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A  20
ALA A  38
SER A  42
GLY A 164
LEU A 165
 None
 1.24A 5m5cE-2z0mA:
undetectable		 5m5cE-2z0mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		4 / 6 VAL A 133
THR A 163
LEU A 116
GLU A  89
 None
 0.97A 5tudD-2z0mA:
undetectable		 5tudD-2z0mA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 226
VAL A 227
PHE A 262
ILE A 259
SER A 277
 None
 1.33A 6ap6A-2z0mA:
undetectable		 6ap6A-2z0mA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 226
VAL A 227
PHE A 262
ILE A 259
SER A 277
 None
 1.33A 6ap6B-2z0mA:
undetectable		 6ap6B-2z0mA:
22.51