SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		4 / 6 VAL A  87
GLY A  88
LEU A 177
GLU A 162
 None
 0.98A 1fduD-2z0qA:
undetectable		 1fduD-2z0qA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		5 / 11 GLN A 245
ILE A 334
ALA A 337
VAL A 271
LEU A 319
 None
 1.28A 1n4hA-2z0qA:
undetectable		 1n4hA-2z0qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		5 / 11 LEU A 248
THR A 251
LEU A 207
PHE A 244
HIS A 228
 None
 1.29A 1tw4A-2z0qA:
undetectable		 1tw4A-2z0qA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		4 / 8 THR A  59
SER A  62
TYR A 101
CYH A 105
 None
 1.13A 2xz5A-2z0qA:
undetectable
2xz5C-2z0qA:
undetectable		 2xz5A-2z0qA:
19.70
2xz5C-2z0qA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		5 / 11 ASN A 171
GLY A  88
THR A  84
ILE A  17
THR A 167
 None
 1.38A 3bf1A-2z0qA:
undetectable
3bf1B-2z0qA:
undetectable		 3bf1A-2z0qA:
19.95
3bf1B-2z0qA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		5 / 11 ASN A 171
GLY A  88
THR A  84
ILE A  17
THR A 167
 None
 1.34A 3bf1C-2z0qA:
undetectable
3bf1D-2z0qA:
undetectable		 3bf1C-2z0qA:
19.95
3bf1D-2z0qA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		5 / 12 HIS A  67
LEU A  20
LEU A 153
LEU A  98
TYR A 101
 None
 1.17A 3cs8A-2z0qA:
undetectable		 3cs8A-2z0qA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		4 / 8 LYS A  35
ASP A  40
LEU A  43
ASN A  54
 None
 0.97A 3lm8A-2z0qA:
undetectable
3lm8C-2z0qA:
undetectable		 3lm8A-2z0qA:
21.51
3lm8C-2z0qA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		3 / 3 ARG A  75
VAL A  87
THR A  84
 None
 0.85A 3nduD-2z0qA:
undetectable		 3nduD-2z0qA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		4 / 5 VAL A 306
LEU A 274
ILE A 269
VAL A 241
 None
 0.96A 4a9kB-2z0qA:
3.2		 4a9kB-2z0qA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		5 / 11 LEU A  95
LEU A 160
HIS A 176
LEU A 177
ALA A 180
 None
 1.00A 4p65B-2z0qA:
undetectable
4p65D-2z0qA:
undetectable
4p65G-2z0qA:
undetectable
4p65H-2z0qA:
undetectable		 4p65B-2z0qA:
7.25
4p65D-2z0qA:
7.25
4p65G-2z0qA:
4.85
4p65H-2z0qA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		4 / 7 ILE A 250
ARG A 305
THR A 275
LEU A 274
 None
SO4  A 501 (-4.4A)
None
None
 0.98A 5b3sA-2z0qA:
undetectable
5b3sJ-2z0qA:
undetectable		 5b3sA-2z0qA:
20.12
5b3sJ-2z0qA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		4 / 7 ILE A  90
HIS A 176
LEU A 177
ALA A 180
 None
 0.99A 5hrqE-2z0qA:
undetectable
5hrqF-2z0qA:
undetectable
5hrqJ-2z0qA:
undetectable		 5hrqE-2z0qA:
4.85
5hrqF-2z0qA:
6.65
5hrqJ-2z0qA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		3 / 3 LEU A  31
ILE A 148
TYR A 156
 None
 0.65A 5uunB-2z0qA:
undetectable		 5uunB-2z0qA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z0q RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 3
(Mus
musculus) 		4 / 7 ILE A 250
ARG A 305
THR A 275
LEU A 274
 None
SO4  A 501 (-4.4A)
None
None
 0.98A 5zcpA-2z0qA:
2.2
5zcpJ-2z0qA:
undetectable		 5zcpA-2z0qA:
20.12
5zcpJ-2z0qA:
10.98