SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Aeropyrum
pernix) 		4 / 8 LEU A 114
VAL A 138
GLY A 144
LEU A 100
 None
 0.95A 1jlbA-2z0sA:
4.2		 1jlbA-2z0sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Aeropyrum
pernix) 		5 / 11 LEU A 143
ASP A 119
ILE A  74
ILE A  86
THR A 137
 None
 1.13A 3spkA-2z0sA:
undetectable		 3spkA-2z0sA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Aeropyrum
pernix) 		5 / 12 TYR A 120
VAL A  84
LEU A 136
ALA A 123
ILE A 154
 None
 1.19A 5hbsA-2z0sA:
undetectable		 5hbsA-2z0sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Aeropyrum
pernix) 		5 / 9 LEU A 114
GLY A 101
LEU A 100
GLN A  97
VAL A 138
 None
 1.00A 6czmA-2z0sA:
undetectable
6czmB-2z0sA:
undetectable		 6czmA-2z0sA:
24.77
6czmB-2z0sA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2z0s PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1
(Aeropyrum
pernix) 		5 / 9 LEU A 114
GLY A 101
LEU A 100
GLN A  97
VAL A 138
 None
 1.06A 6czmB-2z0sA:
undetectable
6czmC-2z0sA:
undetectable		 6czmB-2z0sA:
24.77
6czmC-2z0sA:
24.77