SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z0v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 7 TYR A 202
HIS A 203
LEU A  45
GLN A  36
 None
 1.11A 3jwqC-2z0vA:
undetectable		 3jwqC-2z0vA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 5 TYR A 145
LEU A 138
ASP A   7
GLU A 168
 None
 1.24A 4nkvA-2z0vA:
undetectable		 4nkvA-2z0vA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 6 LEU A 135
SER A 177
PHE A 179
GLU A 183
 None
 1.23A 5b8iA-2z0vA:
undetectable		 5b8iA-2z0vA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3
(Homo
sapiens) 		5 / 12 ILE A 117
GLN A 114
THR A  50
VAL A  51
SER A 107
 None
 1.30A 6bzoC-2z0vA:
undetectable		 6bzoC-2z0vA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3
(Homo
sapiens) 		4 / 8 ILE A 117
GLN A 114
THR A  50
VAL A  51
 None
 1.16A 6fbvC-2z0vA:
undetectable		 6fbvC-2z0vA:
11.67