SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z17'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A  66
PHE A  31
ILE A  75
LEU A  99
TYR A  85
 None
 1.18A 1jomA-2z17A:
undetectable		 1jomA-2z17A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
PHE A  31
ILE A  75
LEU A  99
TYR A  85
 None
 1.10A 1rx3A-2z17A:
undetectable		 1rx3A-2z17A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  66
PHE A  31
ILE A  75
LEU A  99
TYR A  85
 None
 1.09A 1rx8A-2z17A:
undetectable		 1rx8A-2z17A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		4 / 8 ILE A  33
LEU A  72
ARG A  93
LEU A  99
 None
 0.92A 2einA-2z17A:
undetectable
2einJ-2z17A:
undetectable		 2einA-2z17A:
11.11
2einJ-2z17A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		5 / 9 ILE A  33
ILE A  52
VAL A  88
ILE A 101
ILE A  75
 None
 1.24A 3p4wB-2z17A:
undetectable		 3p4wB-2z17A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		5 / 10 ILE A  33
ILE A  52
VAL A  88
ILE A 101
ILE A  75
 None
 1.23A 3p4wE-2z17A:
undetectable		 3p4wE-2z17A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A  82
TYR A  36
SER A  35
GLU A  81
 None
 1.22A 4xueA-2z17A:
undetectable		 4xueA-2z17A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 ILE A  33
PHE A  31
VAL A  88
ILE A  75
 None
 0.92A 4zzbC-2z17A:
undetectable
4zzbD-2z17A:
undetectable		 4zzbC-2z17A:
13.87
4zzbD-2z17A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 ILE A  33
LEU A  72
ARG A  93
LEU A  99
 None
 0.96A 5xdxA-2z17A:
undetectable
5xdxJ-2z17A:
undetectable		 5xdxA-2z17A:
11.11
5xdxJ-2z17A:
27.63