SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z1a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 170
ALA A 110
HIS A 215
ILE A 168
GLY A 114
 None
None
ZN  A5648 (-3.4A)
None
None
 1.17A 1c9sN-2z1aA:
undetectable
1c9sO-2z1aA:
undetectable		 1c9sN-2z1aA:
9.33
1c9sO-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 GLY A 170
ALA A 110
HIS A 215
ILE A 168
GLY A 114
 None
None
ZN  A5648 (-3.4A)
None
None
 1.15A 1c9sP-2z1aA:
undetectable
1c9sQ-2z1aA:
undetectable		 1c9sP-2z1aA:
9.33
1c9sQ-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 9 GLY A 170
ALA A 110
HIS A 215
ILE A 168
GLY A 114
 None
None
ZN  A5648 (-3.4A)
None
None
 1.13A 1c9sQ-2z1aA:
undetectable
1c9sR-2z1aA:
undetectable		 1c9sQ-2z1aA:
9.33
1c9sR-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 7 VAL A 159
VAL A 137
LEU A  32
LEU A  77
 None
 0.77A 1cqpA-2z1aA:
undetectable
1cqpB-2z1aA:
undetectable		 1cqpA-2z1aA:
17.59
1cqpB-2z1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 1gtfJ-2z1aA:
undetectable
1gtfK-2z1aA:
undetectable		 1gtfJ-2z1aA:
9.33
1gtfK-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 9 GLY A 170
ALA A 110
HIS A 215
ILE A 168
GLY A 114
 None
None
ZN  A5648 (-3.4A)
None
None
 1.20A 1gtfR-2z1aA:
undetectable
1gtfS-2z1aA:
undetectable		 1gtfR-2z1aA:
9.33
1gtfS-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 LEU A 376
VAL A 437
VAL A 424
PHE A 434
GLN A 436
 None
 1.23A 1gx9A-2z1aA:
undetectable		 1gx9A-2z1aA:
14.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 ARG A 349
GLY A 379
ASN A 404
GLY A 432
ASP A 487
 PO4  A5646 (-2.9A)
None
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.32A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		6 / 11 ASN A 181
ARG A 349
GLY A 380
PHE A 402
GLY A 432
ASP A 487
 THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
THM  A6510 (-3.7A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 0.96A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		7 / 11 ILE A 179
ARG A 349
GLY A 380
ARG A 383
ASN A 479
GLY A 432
PHE A 481
 THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 ( 4.7A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
 1.42A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		9 / 11 ILE A 179
ARG A 349
GLY A 380
ARG A 383
PHE A 402
ASN A 404
GLY A 432
PHE A 481
ASP A 487
 THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 0.69A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 ILE A 179
GLY A 381
ARG A 383
PHE A 481
ASP A 487
 THM  A6510 (-3.6A)
THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 1.31A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 ARG A 349
GLY A 379
ASN A 404
GLY A 432
ASP A 487
 PO4  A5646 (-2.9A)
None
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.30A 1ho5B-2z1aA:
37.9		 1ho5B-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		8 / 10 ARG A 349
GLY A 380
ARG A 383
PHE A 402
ASN A 404
GLY A 432
PHE A 481
ASP A 487
 PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 0.73A 1ho5B-2z1aA:
37.9		 1ho5B-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 ASN A 181
GLY A 380
ARG A 383
GLY A 432
ASP A 487
 THM  A6510 (-4.1A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 0.85A 1ho5B-2z1aA:
37.9		 1ho5B-2z1aA:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 GLY A 121
SER A 180
THR A 176
PHE A 118
 None
THM  A6510 ( 4.7A)
None
None
 1.21A 1icuC-2z1aA:
undetectable
1icuD-2z1aA:
undetectable		 1icuC-2z1aA:
17.59
1icuD-2z1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 GLY A 121
SER A 180
THR A 176
PHE A 118
 None
THM  A6510 ( 4.7A)
None
None
 1.28A 1icvA-2z1aA:
undetectable
1icvB-2z1aA:
undetectable		 1icvA-2z1aA:
17.59
1icvB-2z1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 SER A 180
THR A 176
PHE A 118
GLY A 121
 THM  A6510 ( 4.7A)
None
None
None
 1.31A 1icvC-2z1aA:
undetectable
1icvD-2z1aA:
undetectable		 1icvC-2z1aA:
17.59
1icvD-2z1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 GLY A 121
SER A 180
THR A 176
PHE A 118
 None
THM  A6510 ( 4.7A)
None
None
 1.26A 1icvC-2z1aA:
undetectable
1icvD-2z1aA:
undetectable		 1icvC-2z1aA:
17.59
1icvD-2z1aA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 THR A 172
GLY A 114
GLY A 217
GLY A 236
 None
 0.76A 1jhvA-2z1aA:
undetectable		 1jhvA-2z1aA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 TYR A 513
GLY A 362
ASP A 361
ILE A 359
GLN A 377
 None
 1.07A 1nt2A-2z1aA:
undetectable		 1nt2A-2z1aA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ASP A  83
HIS A 116
HIS A  39
 ZN  A5648 (-2.7A)
THM  A6510 ( 3.5A)
ZN  A5647 ( 3.4A)
 0.64A 1oe1A-2z1aA:
undetectable		 1oe1A-2z1aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ASP A  83
HIS A 116
HIS A  39
 ZN  A5648 (-2.7A)
THM  A6510 ( 3.5A)
ZN  A5647 ( 3.4A)
 0.64A 1oe3A-2z1aA:
undetectable		 1oe3A-2z1aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 351
VAL A 424
TRP A 427
 None
 1.19A 1qw6A-2z1aA:
undetectable		 1qw6A-2z1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 351
VAL A 424
TRP A 427
 None
 1.21A 1qwcA-2z1aA:
undetectable		 1qwcA-2z1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 VAL A 235
GLY A 236
VAL A 272
TRP A 275
 None
 0.67A 1tkqB-2z1aA:
undetectable		 1tkqB-2z1aA:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 170
ALA A 110
HIS A 215
ILE A 168
GLY A 114
 None
None
ZN  A5648 (-3.4A)
None
None
 1.13A 1utdE-2z1aA:
undetectable
1utdF-2z1aA:
undetectable		 1utdE-2z1aA:
9.33
1utdF-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 170
ALA A 110
HIS A 215
ILE A 168
GLY A 114
 None
None
ZN  A5648 (-3.4A)
None
None
 1.15A 1utdH-2z1aA:
undetectable
1utdI-2z1aA:
undetectable		 1utdH-2z1aA:
9.33
1utdI-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 170
ALA A 110
HIS A 215
ILE A 168
GLY A 114
 None
None
ZN  A5648 (-3.4A)
None
None
 1.18A 1utdU-2z1aA:
undetectable
1utdV-2z1aA:
undetectable		 1utdU-2z1aA:
9.33
1utdV-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ARG A 351
VAL A 424
TRP A 427
 None
 1.25A 1zviA-2z1aA:
undetectable		 1zviA-2z1aA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 ILE A 234
GLY A 236
ASP A  83
HIS A 238
GLY A 114
 None
None
ZN  A5648 (-2.7A)
ZN  A5648 ( 3.3A)
None
 1.04A 1zz1C-2z1aA:
undetectable		 1zz1C-2z1aA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 6 ARG A 226
VAL A 260
LEU A 270
ALA A 225
 None
 1.02A 2e1qA-2z1aA:
undetectable		 2e1qA-2z1aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 6 ARG A 226
VAL A 260
LEU A 270
ALA A 225
 None
 1.00A 2e1qC-2z1aA:
undetectable		 2e1qC-2z1aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 216
GLY A 236
GLN A 273
ALA A 225
LEU A 228
 None
 1.09A 2oz7A-2z1aA:
undetectable		 2oz7A-2z1aA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 319
LEU A 320
MET A 330
MET A 327
VAL A 326
 None
 1.42A 2q7iA-2z1aA:
undetectable		 2q7iA-2z1aA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 ARG A 349
ILE A 179
HIS A 215
ASP A  83
 PO4  A5646 (-2.9A)
THM  A6510 (-3.6A)
ZN  A5648 (-3.4A)
ZN  A5648 (-2.7A)
 1.08A 2xadA-2z1aA:
undetectable		 2xadA-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 ARG A 349
ILE A 179
HIS A 215
ASP A  83
 PO4  A5646 (-2.9A)
THM  A6510 (-3.6A)
ZN  A5648 (-3.4A)
ZN  A5648 (-2.7A)
 1.08A 2xadB-2z1aA:
undetectable		 2xadB-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 ARG A 349
ILE A 179
HIS A 215
ASP A  83
 PO4  A5646 (-2.9A)
THM  A6510 (-3.6A)
ZN  A5648 (-3.4A)
ZN  A5648 (-2.7A)
 1.09A 2xadC-2z1aA:
undetectable		 2xadC-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 ARG A 349
ILE A 179
HIS A 215
ASP A  83
 PO4  A5646 (-2.9A)
THM  A6510 (-3.6A)
ZN  A5648 (-3.4A)
ZN  A5648 (-2.7A)
 1.08A 2xadD-2z1aA:
undetectable		 2xadD-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ASP A  83
HIS A 116
HIS A  39
 ZN  A5648 (-2.7A)
THM  A6510 ( 3.5A)
ZN  A5647 ( 3.4A)
 0.65A 2xxgA-2z1aA:
undetectable		 2xxgA-2z1aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ASP A  83
HIS A 116
HIS A  39
 ZN  A5648 (-2.7A)
THM  A6510 ( 3.5A)
ZN  A5647 ( 3.4A)
 0.66A 2xxgC-2z1aA:
undetectable		 2xxgC-2z1aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 319
LEU A 320
MET A 330
MET A 327
VAL A 326
 None
 1.45A 2yloA-2z1aA:
undetectable		 2yloA-2z1aA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 ASP A  99
PHE A 102
LEU A 106
 None
 0.42A 2zi9A-2z1aA:
undetectable		 2zi9A-2z1aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 PHE A 288
LEU A 284
LEU A 294
VAL A 231
 None
 0.81A 2zujA-2z1aA:
undetectable		 2zujA-2z1aA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 7 GLY A 413
ASP A 410
TYR A 474
ARG A 475
 None
 1.16A 3aruA-2z1aA:
2.2		 3aruA-2z1aA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 PHE A  85
LEU A 113
PHE A 128
LEU A 129
 None
 0.91A 3i45A-2z1aA:
2.7		 3i45A-2z1aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 GLY A 362
ASP A 506
ASP A 361
ILE A 359
GLN A 377
 None
 1.22A 3id5B-2z1aA:
undetectable		 3id5B-2z1aA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 GLY A 362
ASP A 506
ASP A 361
ILE A 359
GLN A 377
 None
 1.22A 3id5F-2z1aA:
undetectable		 3id5F-2z1aA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 TYR A 513
LEU A 514
ILE A 391
ALA A 522
ALA A 337
 None
 0.99A 3mdtB-2z1aA:
undetectable		 3mdtB-2z1aA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 THR A  88
ASP A  99
GLU A 117
 None
 0.49A 3qowA-2z1aA:
undetectable		 3qowA-2z1aA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 GLU A 220
GLY A 217
TYR A 218
GLN A 273
 None
 1.29A 3w9tB-2z1aA:
undetectable		 3w9tB-2z1aA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 GLU A 220
GLY A 217
TYR A 218
GLN A 273
 None
 1.35A 3w9tD-2z1aA:
undetectable		 3w9tD-2z1aA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 5 GLU A 220
GLY A 217
TYR A 218
GLN A 273
 None
 1.43A 3w9tG-2z1aA:
undetectable		 3w9tG-2z1aA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 319
LEU A 320
MET A 330
MET A 327
VAL A 326
 None
 1.41A 3zqtA-2z1aA:
undetectable		 3zqtA-2z1aA:
18.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		6 / 9 ASN A 378
GLY A 379
GLY A 381
ASN A 404
GLY A 432
ASP A 487
 THM  A6510 (-3.4A)
None
THM  A6510 (-3.6A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.16A 3ztvA-2z1aA:
42.3		 3ztvA-2z1aA:
32.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		7 / 9 ASN A 378
GLY A 380
GLY A 381
PHE A 402
ASN A 404
GLY A 432
ASP A 487
 THM  A6510 (-3.4A)
THM  A6510 (-4.1A)
THM  A6510 (-3.6A)
THM  A6510 (-3.7A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 0.36A 3ztvA-2z1aA:
42.3		 3ztvA-2z1aA:
32.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 9 GLY A 380
GLY A 381
PHE A 402
ASN A 479
GLY A 432
 THM  A6510 (-4.1A)
THM  A6510 (-3.6A)
THM  A6510 (-3.7A)
THM  A6510 ( 4.7A)
THM  A6510 (-3.2A)
 1.08A 3ztvA-2z1aA:
42.3		 3ztvA-2z1aA:
32.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 11 GLY A  82
GLY A 114
VAL A  84
MET A 111
VAL A 136
 None
 1.23A 4c5lA-2z1aA:
undetectable		 4c5lA-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 9 GLY A  82
GLY A 114
VAL A  84
MET A 111
VAL A 136
 None
 1.20A 4c5lB-2z1aA:
undetectable		 4c5lB-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A  82
GLY A 114
VAL A  84
MET A 111
VAL A 136
 None
 1.23A 4c5lC-2z1aA:
2.1		 4c5lC-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A  82
GLY A 114
VAL A  84
MET A 111
VAL A 136
 None
 1.19A 4c5lD-2z1aA:
2.0		 4c5lD-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A  82
GLY A 114
VAL A  84
MET A 111
VAL A 136
 None
 1.18A 4c5nB-2z1aA:
2.1		 4c5nB-2z1aA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A  82
GLY A 114
VAL A  84
MET A 111
VAL A 136
 None
 1.29A 4c5nD-2z1aA:
undetectable		 4c5nD-2z1aA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		6 / 9 ARG A 349
ASN A 378
GLY A 379
GLY A 381
GLY A 432
ASP A 487
 PO4  A5646 (-2.9A)
THM  A6510 (-3.4A)
None
THM  A6510 (-3.6A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.12A 4h2fA-2z1aA:
45.3		 4h2fA-2z1aA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		9 / 9 ARG A 349
ASN A 378
GLY A 380
GLY A 381
ARG A 383
PHE A 402
GLY A 432
PHE A 481
ASP A 487
 PO4  A5646 (-2.9A)
THM  A6510 (-3.4A)
THM  A6510 (-4.1A)
THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 0.57A 4h2fA-2z1aA:
45.3		 4h2fA-2z1aA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		7 / 9 ARG A 349
ASN A 378
GLY A 379
GLY A 381
PHE A 402
GLY A 432
ASP A 487
 PO4  A5646 (-2.9A)
THM  A6510 (-3.4A)
None
THM  A6510 (-3.6A)
THM  A6510 (-3.7A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.15A 4h2gA-2z1aA:
45.5		 4h2gA-2z1aA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		9 / 9 ARG A 349
ASN A 378
GLY A 380
GLY A 381
ARG A 383
PHE A 402
GLY A 432
PHE A 481
ASP A 487
 PO4  A5646 (-2.9A)
THM  A6510 (-3.4A)
THM  A6510 (-4.1A)
THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 0.63A 4h2gA-2z1aA:
45.5		 4h2gA-2z1aA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 9 ASN A 378
GLY A 380
ARG A 383
PHE A 402
ASP A 487
 THM  A6510 (-3.4A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 1.20A 4h2gA-2z1aA:
45.5		 4h2gA-2z1aA:
37.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.42A 4lvcB-2z1aA:
2.2		 4lvcB-2z1aA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 381
GLY A 380
ASN A 378
GLY A 486
ASP A 487
 THM  A6510 (-3.6A)
THM  A6510 (-4.1A)
THM  A6510 (-3.4A)
None
THM  A6510 (-2.4A)
 0.89A 4n09B-2z1aA:
undetectable		 4n09B-2z1aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 381
GLY A 380
ASN A 378
GLY A 486
ASP A 487
 THM  A6510 (-3.6A)
THM  A6510 (-4.1A)
THM  A6510 (-3.4A)
None
THM  A6510 (-2.4A)
 0.90A 4n09C-2z1aA:
undetectable		 4n09C-2z1aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 ASP A  83
ARG A 383
THR A 173
THR A 176
ASP A 119
 ZN  A5648 (-2.7A)
PO4  A5646 (-2.9A)
None
None
THM  A6510 (-3.7A)
 1.49A 4n9uA-2z1aA:
undetectable		 4n9uA-2z1aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 222
ASP A 221
SER A 214
ALA A 195
LEU A 294
 None
 1.25A 4nc3A-2z1aA:
undetectable		 4nc3A-2z1aA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 THR A 360
GLY A 379
GLY A 381
ASP A 506
 None
None
THM  A6510 (-3.6A)
None
 0.74A 4qvvK-2z1aA:
undetectable
4qvvL-2z1aA:
undetectable		 4qvvK-2z1aA:
17.80
4qvvL-2z1aA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 8 THR A 360
GLY A 379
GLY A 381
ASP A 506
 None
None
THM  A6510 (-3.6A)
None
 0.74A 4qvvY-2z1aA:
undetectable
4qvvZ-2z1aA:
undetectable		 4qvvY-2z1aA:
17.80
4qvvZ-2z1aA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 381
GLY A 380
ASN A 378
ALA A 431
ASP A 487
 THM  A6510 (-3.6A)
THM  A6510 (-4.1A)
THM  A6510 (-3.4A)
None
THM  A6510 (-2.4A)
 1.14A 4ubeA-2z1aA:
undetectable		 4ubeA-2z1aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.14A 5eevA-2z1aA:
undetectable
5eevB-2z1aA:
undetectable		 5eevA-2z1aA:
9.33
5eevB-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5eewA-2z1aA:
undetectable
5eewB-2z1aA:
undetectable		 5eewA-2z1aA:
9.33
5eewB-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5eexA-2z1aA:
undetectable
5eexB-2z1aA:
undetectable		 5eexA-2z1aA:
9.33
5eexB-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5eeyA-2z1aA:
undetectable
5eeyB-2z1aA:
undetectable		 5eeyA-2z1aA:
9.33
5eeyB-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5eezA-2z1aA:
undetectable
5eezB-2z1aA:
undetectable		 5eezA-2z1aA:
9.33
5eezB-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5ef0A-2z1aA:
undetectable
5ef0B-2z1aA:
undetectable		 5ef0A-2z1aA:
9.33
5ef0B-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5ef1A-2z1aA:
undetectable
5ef1B-2z1aA:
undetectable		 5ef1A-2z1aA:
9.33
5ef1B-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5ef2A-2z1aA:
undetectable
5ef2B-2z1aA:
undetectable		 5ef2A-2z1aA:
9.33
5ef2B-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 10 GLY A 114
GLY A 170
ALA A 110
HIS A 215
ILE A 168
 None
None
None
ZN  A5648 (-3.4A)
None
 1.13A 5ef3A-2z1aA:
undetectable
5ef3B-2z1aA:
undetectable		 5ef3A-2z1aA:
9.33
5ef3B-2z1aA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		3 / 3 THR A  88
ASP A  99
GLU A 117
 None
 0.56A 5fa8A-2z1aA:
undetectable		 5fa8A-2z1aA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.48A 5hm8A-2z1aA:
2.4		 5hm8A-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.48A 5hm8B-2z1aA:
2.4		 5hm8B-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.49A 5hm8C-2z1aA:
2.4		 5hm8C-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.49A 5hm8D-2z1aA:
2.4		 5hm8D-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.49A 5hm8E-2z1aA:
undetectable		 5hm8E-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.49A 5hm8F-2z1aA:
undetectable		 5hm8F-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.48A 5hm8G-2z1aA:
undetectable		 5hm8G-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
THR A 172
ASP A  83
ASP A 119
HIS A 240
 ZN  A5648 (-3.4A)
None
ZN  A5648 (-2.7A)
THM  A6510 (-3.7A)
ZN  A5647 ( 3.5A)
 1.49A 5hm8H-2z1aA:
undetectable		 5hm8H-2z1aA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 9 ILE A 374
MET A 363
LEU A 492
ILE A 482
LEU A 468
 None
 1.49A 5iepA-2z1aA:
undetectable		 5iepA-2z1aA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 216
ASP A  37
GLY A  82
ASN A 140
PHE A 188
 None
ZN  A5647 (-3.0A)
None
None
None
 1.30A 5kc4A-2z1aA:
undetectable		 5kc4A-2z1aA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 GLY A  58
VAL A 281
VAL A  63
ALA A  64
LEU A  65
 None
 1.09A 5kocA-2z1aA:
undetectable		 5kocA-2z1aA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		6 / 12 GLY A  58
VAL A 281
VAL A  63
ALA A  64
LEU A  65
ALA A 308
 None
 1.25A 5kpcA-2z1aA:
undetectable		 5kpcA-2z1aA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 HIS A 215
LEU A 113
SER A 180
ARG A 383
GLY A  87
 ZN  A5648 (-3.4A)
None
THM  A6510 ( 4.7A)
PO4  A5646 (-2.9A)
None
 0.92A 5m5cB-2z1aA:
undetectable		 5m5cB-2z1aA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 4 ASP A  83
HIS A 215
HIS A 238
HIS A 116
 ZN  A5648 (-2.7A)
ZN  A5648 (-3.4A)
ZN  A5648 ( 3.3A)
THM  A6510 ( 3.5A)
 1.47A 5ncdD-2z1aA:
undetectable		 5ncdD-2z1aA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 ILE A 234
LEU A 224
SER A 239
GLY A 236
GLY A 217
 None
 1.23A 5nnaB-2z1aA:
undetectable		 5nnaB-2z1aA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 362
LYS A 366
ASN A 479
LEU A 376
LEU A 435
 None
None
THM  A6510 ( 4.7A)
None
None
 1.12A 5nwwA-2z1aA:
undetectable		 5nwwA-2z1aA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 6 LEU A 125
PHE A 118
ASP A 119
HIS A 215
 None
None
THM  A6510 (-3.7A)
ZN  A5648 (-3.4A)
 1.10A 5om3A-2z1aA:
undetectable
5om3B-2z1aA:
undetectable		 5om3A-2z1aA:
10.20
5om3B-2z1aA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 6 LEU A 492
LEU A 411
LEU A 470
GLU A 421
 None
 0.91A 5tudD-2z1aA:
undetectable		 5tudD-2z1aA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2z1a 5'-NUCLEOTIDASE
(Thermus
thermophilus) 		4 / 6 MET A 111
LEU A  79
MET A 103
THR A  38
 None
 0.97A 6mvxA-2z1aA:
undetectable
6mvxB-2z1aA:
undetectable
6mvxC-2z1aA:
undetectable		 6mvxA-2z1aA:
18.23
6mvxB-2z1aA:
18.23
6mvxC-2z1aA:
18.23