SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		4 / 8 PHE A  36
ALA A 211
ARG A 209
LEU A  50
 None
 0.93A 2bxmA-2z1bA:
undetectable		 2bxmA-2z1bA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		4 / 8 ARG A 147
ALA A 177
ILE A 178
PRO A 167
 None
 0.90A 3fxrA-2z1bA:
undetectable		 3fxrA-2z1bA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		5 / 11 ALA A 154
ALA A 151
VAL A 165
ALA A 158
SER A  99
 None
 0.90A 3mg0K-2z1bA:
undetectable
3mg0L-2z1bA:
undetectable		 3mg0K-2z1bA:
19.94
3mg0L-2z1bA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		5 / 12 ALA A 154
ALA A 151
VAL A 165
ALA A 158
SER A  99
 None
 0.87A 3mg0Y-2z1bA:
undetectable
3mg0Z-2z1bA:
undetectable		 3mg0Y-2z1bA:
19.94
3mg0Z-2z1bA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		5 / 12 ALA A 299
LEU A 301
THR A 303
LEU A 323
ILE A 315
 None
 1.13A 4g1bA-2z1bA:
undetectable		 4g1bA-2z1bA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		4 / 8 PRO A  51
VAL A  53
PRO A  34
GLN A 322
 None
 0.97A 4iilA-2z1bA:
2.3		 4iilA-2z1bA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		5 / 10 ARG A 240
ALA A 239
VAL A 264
MET A 260
PHE A 200
 None
 1.49A 4j4vB-2z1bA:
undetectable		 4j4vB-2z1bA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		4 / 8 ALA A 320
PRO A  34
LEU A  68
LEU A 324
 None
 0.95A 4jjkA-2z1bA:
1.9		 4jjkA-2z1bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		5 / 12 ASP A 259
LEU A 258
MET A 250
LEU A 249
PRO A 256
 None
 1.32A 4xi3A-2z1bA:
undetectable		 4xi3A-2z1bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		3 / 3 ILE A 178
MET A 250
ASP A 169
 None
 0.81A 5h2uA-2z1bA:
undetectable		 5h2uA-2z1bA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		4 / 8 LEU A 273
LEU A 258
TYR A 276
GLN A 225
 None
 0.97A 5hbsA-2z1bA:
undetectable		 5hbsA-2z1bA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Mus
musculus) 		5 / 11 LEU A 235
LEU A 226
ALA A 230
VAL A 175
LEU A 249
 None
 1.22A 5ji0A-2z1bA:
undetectable		 5ji0A-2z1bA:
23.49