SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		3 / 3 LEU A  79
PRO A  80
LEU A  83
 None
 0.51A 1hrkA-2z1pA:
undetectable		 1hrkA-2z1pA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		4 / 7 THR A 227
ILE A 275
ASN A 197
PHE A 195
 None
 0.96A 2jc9A-2z1pA:
undetectable		 2jc9A-2z1pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		4 / 5 LEU A  79
PRO A  80
LEU A  83
ILE A 133
 None
 0.89A 2qd4A-2z1pA:
undetectable		 2qd4A-2z1pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 GLN A 246
PHE A 244
LEU A 241
ALA A 242
ILE A 209
 None
 1.00A 3fc6A-2z1pA:
undetectable		 3fc6A-2z1pA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 PHE A  61
PHE A 115
LEU A  77
VAL A  42
VAL A 111
 None
 1.30A 3u9fP-2z1pA:
undetectable
3u9fS-2z1pA:
undetectable		 3u9fP-2z1pA:
19.77
3u9fS-2z1pA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 ILE A 252
GLN A 246
PHE A 244
LEU A 241
ALA A 242
 None
 1.15A 4nqaA-2z1pA:
undetectable		 4nqaA-2z1pA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 ILE A 252
GLN A 246
PHE A 244
LEU A 241
ALA A 242
 None
 1.12A 5ji0A-2z1pA:
undetectable		 5ji0A-2z1pA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		4 / 7 VAL A 276
VAL A 198
PHE A 179
ASP A 213
 None
 0.85A 5yf9B-2z1pA:
undetectable		 5yf9B-2z1pA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		5 / 9 VAL A 276
VAL A 198
ILE A 298
ILE A 211
ASP A 213
 None
 1.04A 5yf9X-2z1pA:
undetectable		 5yf9X-2z1pA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		5 / 9 VAL A 276
VAL A 198
ILE A 298
PHE A 179
ASP A 213
 None
 1.00A 5yf9X-2z1pA:
undetectable		 5yf9X-2z1pA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A 252
GLN A 246
PHE A 244
LEU A 241
ALA A 242
 None
 1.01A 5z12C-2z1pA:
undetectable		 5z12C-2z1pA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2z1p COLLAGEN ADHESIN
PROTEIN
(Enterococcus
faecalis) 		3 / 3 GLY A  85
THR A  87
GLU A 188
 None
 0.59A 6b58A-2z1pA:
undetectable		 6b58A-2z1pA:
20.17