SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z1q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 ILE A 485
LEU A 456
MET A 459
ALA A 461
VAL A 482
 None
 1.49A 1a29A-2z1qA:
undetectable		 1a29A-2z1qA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 485
GLY A 524
ALA A 525
SER A 527
LEU A 529
 None
 1.04A 1eqhA-2z1qA:
undetectable		 1eqhA-2z1qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 485
GLY A 524
ALA A 525
SER A 527
LEU A 529
 None
 1.03A 1eqhB-2z1qA:
undetectable		 1eqhB-2z1qA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU A 493
ALA A 495
SER A 318
 None
 0.69A 1errB-2z1qA:
1.1		 1errB-2z1qA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ARG A 531
LEU A 532
VAL A 482
GLY A 480
 None
 1.01A 1hrkB-2z1qA:
undetectable		 1hrkB-2z1qA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU A 267
VAL A 108
GLY A 111
ALA A 112
SER A 115
 None
None
None
FAD  A 700 ( 4.6A)
None
 1.17A 1pxxB-2z1qA:
undetectable		 1pxxB-2z1qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 LEU A 267
VAL A 108
GLY A 111
ALA A 112
SER A 115
 None
None
None
FAD  A 700 ( 4.6A)
None
 1.17A 1pxxD-2z1qA:
undetectable		 1pxxD-2z1qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ASN A 394
GLY A 358
SER A 183
GLY A 105
ILE A 225
 None
None
FAD  A 700 (-2.7A)
None
None
 1.11A 1q8jB-2z1qA:
undetectable		 1q8jB-2z1qA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A 269
LEU A 267
GLY A 263
GLY A 111
 None
 0.87A 1rukH-2z1qA:
undetectable
1rukL-2z1qA:
undetectable		 1rukH-2z1qA:
15.42
1rukL-2z1qA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 505
ILE A 575
LEU A 502
GLY A 503
GLY A 504
 None
 0.88A 1uakA-2z1qA:
undetectable		 1uakA-2z1qA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 VAL A 259
TYR A 123
THR A 114
TYR A 146
 None
 0.96A 1z2bB-2z1qA:
undetectable		 1z2bB-2z1qA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 VAL A  95
THR A  94
VAL A 324
GLY A 325
 None
 1.16A 2p2fB-2z1qA:
undetectable		 2p2fB-2z1qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 252
GLY A 250
THR A 203
THR A 192
ILE A 255
 None
 1.11A 2wa2A-2z1qA:
undetectable		 2wa2A-2z1qA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 VAL A 365
GLY A 273
GLU A  98
GLY A 268
ALA A 271
 None
 1.14A 3aruA-2z1qA:
undetectable		 3aruA-2z1qA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 PRO A 337
TYR A 123
GLY A 125
THR A 126
 None
 1.31A 3ib0A-2z1qA:
undetectable		 3ib0A-2z1qA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 LEU A 497
ALA A 491
ILE A 354
ALA A 351
GLU A 346
GLY A 325
 None
 1.36A 3nxuA-2z1qA:
undetectable		 3nxuA-2z1qA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU A 134
ILE A 116
ARG A 231
LEU A 206
VAL A 207
 None
 1.32A 3oxzA-2z1qA:
undetectable		 3oxzA-2z1qA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 GLY A 369
LYS A 305
ASP A 363
ARG A 312
LEU A 362
 None
 1.42A 3ur0C-2z1qA:
0.5		 3ur0C-2z1qA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A  39
LEU A  75
LEU A  74
VAL A  47
VAL A  43
 None
 1.41A 4c9kB-2z1qA:
undetectable		 4c9kB-2z1qA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A  39
LEU A  75
LEU A  74
VAL A  47
VAL A  43
 None
 1.40A 4c9pA-2z1qA:
undetectable		 4c9pA-2z1qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ASP A 328
GLU A  26
ASP A  29
GLU A  30
 None
 1.07A 4feuD-2z1qA:
0.5		 4feuD-2z1qA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TYR A 321
LEU A 502
VAL A 567
ALA A 566
 None
 1.16A 4nkvC-2z1qA:
undetectable		 4nkvC-2z1qA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ILE A 225
ASP A 390
ARG A 386
VAL A  47
 None
 0.91A 4oltA-2z1qA:
0.7		 4oltA-2z1qA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ILE A 225
ASP A 390
ARG A 386
VAL A  47
 None
 0.90A 4oltB-2z1qA:
1.1		 4oltB-2z1qA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ASN A 261
VAL A 259
GLU A 398
GLY A 399
ILE A 396
 None
 1.46A 4xucA-2z1qA:
undetectable		 4xucA-2z1qA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 390
VAL A 366
LEU A 362
 None
 0.65A 5e5jB-2z1qA:
undetectable		 5e5jB-2z1qA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU A 559
ILE A 512
PRO A 507
LEU A 505
 None
 1.19A 5eb3A-2z1qA:
undetectable		 5eb3A-2z1qA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 ALA A 339
PRO A  80
GLY A 140
LEU A 121
 None
 1.00A 5eslA-2z1qA:
undetectable		 5eslA-2z1qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 VAL A 324
THR A 323
ILE A 327
TYR A 123
GLY A 263
 None
 1.14A 5mxbA-2z1qA:
undetectable		 5mxbA-2z1qA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TYR A 123
LEU A 246
GLY A 247
PHE A 124
 None
 1.02A 5nooC-2z1qA:
undetectable		 5nooC-2z1qA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 TYR A 173
VAL A 197
HIS A 201
ILE A 249
 None
 0.84A 5v0vA-2z1qA:
undetectable		 5v0vA-2z1qA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLN A 371
GLY A 374
ILE A 296
GLN A 288
 None
 1.04A 5vlmD-2z1qA:
1.0		 5vlmD-2z1qA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 505
ILE A 575
LEU A 502
GLY A 503
GLY A 504
 None
 0.88A 5wyqB-2z1qA:
undetectable		 5wyqB-2z1qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 PRO A 120
THR A 192
TYR A 146
PRO A 135
 None
 1.19A 5x2sI-2z1qA:
undetectable
5x2sJ-2z1qA:
undetectable
5x2sK-2z1qA:
undetectable		 5x2sI-2z1qA:
14.21
5x2sJ-2z1qA:
15.76
5x2sK-2z1qA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 GLU A 317
TYR A 573
GLY A 572
GLY A 571
 None
 0.77A 5x7pB-2z1qA:
undetectable		 5x7pB-2z1qA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 505
ILE A 575
LEU A 502
GLY A 503
GLY A 504
 None
 0.86A 5zhmB-2z1qA:
undetectable		 5zhmB-2z1qA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PRO A 409
ILE A 485
ASP A 488
ALA A 491
ILE A 408
 None
 1.44A 5zovB-2z1qA:
0.0		 5zovB-2z1qA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 7 GLY A 105
GLY A 104
GLY A 102
GLY A 273
GLY A 274
 None
 0.84A 6ag0A-2z1qA:
undetectable		 6ag0A-2z1qA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLY A 410
LEU A 412
VAL A 460
VAL A 472
ALA A 464
 None
 0.90A 6czmA-2z1qA:
undetectable
6czmC-2z1qA:
undetectable		 6czmA-2z1qA:
21.47
6czmC-2z1qA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR A 513
ALA A 319
LEU A 357
 None
 0.75A 6d9kF-2z1qA:
undetectable		 6d9kF-2z1qA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2z1q ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 SER A 107
GLY A 111
THR A 114
ILE A  77
 None
 0.75A 6f8cA-2z1qA:
0.8		 6f8cA-2z1qA:
9.80