SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 7 LEU A 337
LEU A 264
GLY A 223
LEU A 332
 None
 0.86A 1gtiA-2z1uA:
undetectable		 1gtiA-2z1uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 4 GLY A 176
ASP A 174
GLY A 270
THR A  70
 None
 0.96A 1hxbB-2z1uA:
undetectable		 1hxbB-2z1uA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		5 / 11 ASP A 174
GLY A  65
GLY A  66
PHE A  63
HIS A  74
 None
 1.27A 1w76A-2z1uA:
undetectable		 1w76A-2z1uA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 5 PHE A  25
LEU A  96
PHE A  29
MET A 112
 None
 1.28A 1wrkB-2z1uA:
undetectable		 1wrkB-2z1uA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		5 / 12 GLY A 233
ALA A 232
ILE A 275
ALA A 225
VAL A 317
 None
 1.06A 2b7zB-2z1uA:
undetectable		 2b7zB-2z1uA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 PHE A  94
PHE A  25
PHE A  29
 None
 0.85A 2od9A-2z1uA:
undetectable		 2od9A-2z1uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 4 SER A 169
GLY A 170
HIS A  74
ASP A  67
 None
 1.32A 2oxtC-2z1uA:
undetectable		 2oxtC-2z1uA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 PHE A  94
PHE A  25
PHE A  29
 None
 0.85A 2qqgA-2z1uA:
undetectable		 2qqgA-2z1uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 ARG A 280
GLU A 279
SER A 235
 None
 0.72A 2xctD-2z1uA:
undetectable		 2xctD-2z1uA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 4 GLY A 176
ASP A 174
GLY A 270
THR A  70
 None
 0.96A 3k4vC-2z1uA:
undetectable		 3k4vC-2z1uA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 8 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.86A 3ln1A-2z1uA:
undetectable		 3ln1A-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 7 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.86A 3ln1B-2z1uA:
undetectable		 3ln1B-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 7 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.87A 3ln1C-2z1uA:
undetectable		 3ln1C-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 5 LEU A  24
ARG A 117
ILE A 123
PHE A  29
 None
 0.86A 3ln1D-2z1uA:
undetectable		 3ln1D-2z1uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		5 / 9 ASP A 195
THR A 220
ASN A 268
GLY A 173
ASP A 174
 None
ATP  A 342 (-2.9A)
None
None
None
 1.45A 3sfuA-2z1uA:
undetectable		 3sfuA-2z1uA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		5 / 12 LEU A 285
GLY A 301
ILE A 168
ASP A 164
ALA A 165
 None
 1.38A 3uj7A-2z1uA:
undetectable		 3uj7A-2z1uA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		5 / 12 GLN A 234
GLY A 233
ASN A 229
ILE A 231
VAL A 215
 None
 1.17A 4dx5B-2z1uA:
1.7		 4dx5B-2z1uA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 PHE A  25
VAL A 109
GLU A 106
 None
 0.83A 4fvqA-2z1uA:
undetectable		 4fvqA-2z1uA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 LEU A   7
ASP A   9
TYR A  10
 None
 0.60A 4qc6B-2z1uA:
undetectable		 4qc6B-2z1uA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		5 / 12 ILE A 231
GLY A 157
HIS A 214
VAL A 215
ILE A 273
 None
 1.07A 4rvdA-2z1uA:
undetectable		 4rvdA-2z1uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 SER A  55
ALA A  72
VAL A  73
 None
 0.58A 4x1iA-2z1uA:
undetectable		 4x1iA-2z1uA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 SER A  55
ALA A  72
VAL A  73
 None
 0.58A 5eypA-2z1uA:
undetectable		 5eypA-2z1uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		5 / 12 LEU A  34
ILE A 123
VAL A 109
ASP A 127
PHE A  94
 None
 1.13A 5vlmG-2z1uA:
undetectable		 5vlmG-2z1uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		3 / 3 ILE A 179
THR A 178
PRO A  60
 None
 0.58A 6ncsA-2z1uA:
undetectable		 6ncsA-2z1uA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Desulfovibrio
vulgaris) 		4 / 7 ALA A 311
GLY A 310
LEU A 309
GLY A 315
 None
 0.86A 6nm4A-2z1uA:
undetectable		 6nm4A-2z1uA:
21.18