SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 246
ALA X 227
SER X 226
GLY X 214
SER X 211
 None
 0.90A 1kiaA-2z22X:
undetectable		 1kiaA-2z22X:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 246
ALA X 227
SER X 226
GLY X 214
SER X 211
 None
 0.89A 1nbiA-2z22X:
undetectable		 1nbiA-2z22X:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 246
ALA X 227
SER X 226
GLY X 214
SER X 211
 None
 0.89A 1nbiB-2z22X:
undetectable		 1nbiB-2z22X:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 246
ALA X 227
SER X 226
GLY X 214
SER X 211
 None
 0.92A 1nbiC-2z22X:
undetectable		 1nbiC-2z22X:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 246
ALA X 227
SER X 226
GLY X 214
SER X 211
 None
 0.93A 1nbiD-2z22X:
undetectable		 1nbiD-2z22X:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 176
GLY X 174
VAL X 194
GLU X 195
ALA X 182
 None
 1.02A 1nv8B-2z22X:
undetectable		 1nv8B-2z22X:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 176
GLY X 174
VAL X 194
GLU X 195
ALA X 182
 None
 1.01A 1sg9B-2z22X:
undetectable		 1sg9B-2z22X:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X 176
GLY X 174
VAL X 194
GLU X 195
ALA X 182
 None
 0.89A 1vq1B-2z22X:
undetectable		 1vq1B-2z22X:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 PHE X  11
GLY X 140
LEU X 149
VAL X  80
TYR X 193
 None
PO4  X2322 (-3.4A)
None
None
None
 1.44A 2nyrB-2z22X:
undetectable		 2nyrB-2z22X:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 11 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
 None
 1.05A 2y7kA-2z22X:
5.7		 2y7kA-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
 None
 1.13A 2y7kC-2z22X:
10.2		 2y7kC-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
 None
 1.12A 2y7kD-2z22X:
4.9		 2y7kD-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 10 GLY X   6
GLY X  53
PHE X 277
PRO X  12
ILE X 258
 None
 1.00A 2y7pA-2z22X:
10.3		 2y7pA-2z22X:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 6 ARG X 135
PRO X 219
GLY X  78
TRP X 250
 PO4  X2322 (-2.8A)
None
None
None
 1.47A 3aqiA-2z22X:
undetectable		 3aqiA-2z22X:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 4 THR X  74
VAL X 260
GLY X   6
THR X   5
 None
 1.03A 3cflA-2z22X:
5.8		 3cflA-2z22X:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		3 / 3 ILE X  45
SER X  55
SER X  39
 None
 0.57A 3iltH-2z22X:
9.0		 3iltH-2z22X:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		3 / 3 SER X 139
GLY X 140
THR X 141
 PO4  X2322 (-2.5A)
PO4  X2322 (-3.4A)
PO4  X2322 (-3.6A)
 0.11A 3k9wA-2z22X:
undetectable		 3k9wA-2z22X:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 ALA X  54
TYR X 281
TYR X  33
GLY X  53
ILE X 258
 None
 1.33A 3vwqA-2z22X:
undetectable		 3vwqA-2z22X:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 8 ASP X 102
ILE X 103
GLY X 101
VAL X  83
 None
 0.88A 4acbB-2z22X:
undetectable
4acbC-2z22X:
undetectable		 4acbB-2z22X:
22.76
4acbC-2z22X:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 ALA X  20
PHE X 277
PHE X 276
PHE X  72
THR X  74
 None
 1.38A 4iaqA-2z22X:
undetectable		 4iaqA-2z22X:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 LEU X 296
SER X 254
TRP X 233
PRO X  58
ASP X 232
 None
 1.49A 4j7xJ-2z22X:
undetectable		 4j7xJ-2z22X:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 9 ASP X  56
ALA X   7
GLY X 138
SER X  55
GLY X  41
 PO4  X2322 (-2.8A)
None
None
None
None
 1.34A 4mmeA-2z22X:
undetectable		 4mmeA-2z22X:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 5 LEU X 125
ASP X 113
TRP X 111
ILE X 103
 None
 1.08A 4mwrA-2z22X:
undetectable		 4mwrA-2z22X:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 4 LYS X 200
ASN X 177
ASP X  56
ASP X 292
 None
PO4  X2322 ( 4.7A)
PO4  X2322 (-2.8A)
None
 1.44A 4o1eB-2z22X:
0.0		 4o1eB-2z22X:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 9 THR X  10
ALA X  13
GLY X  40
GLY X  41
ALA X   7
 PO4  X2322 (-2.9A)
None
None
None
None
 1.07A 4qvmK-2z22X:
undetectable
4qvmL-2z22X:
undetectable		 4qvmK-2z22X:
21.85
4qvmL-2z22X:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 7 ALA X   9
THR X  10
ALA X  13
THR X 256
 PO4  X2322 (-3.2A)
PO4  X2322 (-2.9A)
None
None
 0.91A 4qw0K-2z22X:
undetectable		 4qw0K-2z22X:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 7 ALA X   9
THR X  10
ALA X  13
THR X 256
 PO4  X2322 (-3.2A)
PO4  X2322 (-2.9A)
None
None
 0.91A 4qw0Y-2z22X:
undetectable		 4qw0Y-2z22X:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 6 PRO X  73
ILE X  76
VAL X  15
PHE X  11
 None
 0.99A 4xe5A-2z22X:
undetectable		 4xe5A-2z22X:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		3 / 3 THR X 256
THR X 255
PHE X 224
 None
 0.82A 5cxvA-2z22X:
undetectable		 5cxvA-2z22X:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 9 THR X  10
ALA X  13
GLY X  40
GLY X  41
ALA X   7
 PO4  X2322 (-2.9A)
None
None
None
None
 1.08A 5d0xK-2z22X:
undetectable
5d0xL-2z22X:
undetectable		 5d0xK-2z22X:
22.60
5d0xL-2z22X:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 9 THR X  10
ALA X  13
GLY X  40
GLY X  41
ALA X   7
 PO4  X2322 (-2.9A)
None
None
None
None
 1.08A 5d0xY-2z22X:
undetectable
5d0xZ-2z22X:
undetectable		 5d0xY-2z22X:
22.60
5d0xZ-2z22X:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 8 ASN X  48
THR X   5
GLN X  44
ILE X  45
GLY X   6
 None
 1.26A 5nzxA-2z22X:
undetectable		 5nzxA-2z22X:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 7 ASN X  48
THR X   5
GLN X  44
ILE X  45
GLY X   6
 None
 1.26A 5nzyA-2z22X:
undetectable		 5nzyA-2z22X:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 10 SER X 164
ILE X  36
SER X  39
SER X  55
GLY X  40
 None
 1.44A 5weoA-2z22X:
4.0
5weoD-2z22X:
8.2		 5weoA-2z22X:
16.60
5weoD-2z22X:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 9 VAL X  42
VAL X 144
SER X 147
ASP X  56
 None
None
None
PO4  X2322 (-2.8A)
 0.99A 6c2mD-2z22X:
undetectable		 6c2mD-2z22X:
15.91