SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z23'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 4 HIS A  29
LEU A 134
LEU A 118
LEU A 158
None
1.21A 1a4lD-2z23A:
undetectable
1a4lD-2z23A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B2H_A_ACTA518_0
(LYS-ORN-LYS
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 6 TYR A 245
ASN A 247
ASN A 366
HIS A 371
TRP A 397
None
0.31A 1b2hA-2z23A:
62.2
1b2hB-2z23A:
undetectable
1b2hA-2z23A:
79.88
1b2hB-2z23A:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 12 LEU A 158
LEU A 155
VAL A 152
SER A 149
LEU A 431
None
1.35A 1db1A-2z23A:
undetectable
1db1A-2z23A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 SER A 424
LEU A 158
TYR A 154
MET A 164
None
1.04A 1fduB-2z23A:
undetectable
1fduB-2z23A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 365
TYR A 273
MET A 297
VAL A 482
None
1.07A 1fduB-2z23A:
undetectable
1fduB-2z23A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 VAL A 289
LEU A 293
PRO A 283
VAL A 390
None
1.03A 1fduB-2z23A:
undetectable
1fduB-2z23A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
3 / 3 LEU A 504
PRO A 503
LEU A 270
None
0.54A 1hrkA-2z23A:
undetectable
1hrkA-2z23A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 LYS A 137
THR A 147
THR A  73
VAL A  71
None
0.70A 1ictD-2z23A:
undetectable
1ictD-2z23A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 12 GLY A 324
ASN A 421
LEU A 327
TYR A 321
TYR A 484
None
1.41A 1pj7A-2z23A:
1.6
1pj7A-2z23A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 321
GLY A 500
ASP A 502
TYR A 269
None
0.99A 1rmtC-2z23A:
undetectable
1rmtC-2z23A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 5 ALA A  10
TYR A 494
ILE A 515
ASP A 242
None
1.07A 1upfA-2z23A:
undetectable
1upfA-2z23A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 5 ALA A  10
TYR A 494
ILE A 515
ASP A 242
None
0.84A 1upfC-2z23A:
undetectable
1upfC-2z23A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 420
TYR A 115
LEU A 100
MET A 164
None
1.41A 1uw6A-2z23A:
undetectable
1uw6B-2z23A:
undetectable
1uw6A-2z23A:
16.96
1uw6B-2z23A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 420
TYR A 115
LEU A 100
MET A 164
None
1.39A 1uw6D-2z23A:
undetectable
1uw6E-2z23A:
undetectable
1uw6D-2z23A:
16.96
1uw6E-2z23A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 420
TYR A 115
LEU A 100
MET A 164
None
1.39A 1uw6G-2z23A:
undetectable
1uw6H-2z23A:
undetectable
1uw6G-2z23A:
16.96
1uw6H-2z23A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 420
TYR A 115
LEU A 100
MET A 164
None
1.39A 1uw6P-2z23A:
undetectable
1uw6Q-2z23A:
undetectable
1uw6P-2z23A:
16.96
1uw6Q-2z23A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 LEU A 100
MET A 164
TYR A 420
TYR A 115
None
1.38A 1uw6P-2z23A:
undetectable
1uw6T-2z23A:
undetectable
1uw6P-2z23A:
16.96
1uw6T-2z23A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 12 THR A 143
LEU A 144
ILE A  76
VAL A  88
LEU A 159
None
1.29A 1wsvA-2z23A:
undetectable
1wsvA-2z23A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 12 THR A 143
LEU A 144
ILE A  76
VAL A  88
LEU A 159
None
1.33A 1wsvB-2z23A:
undetectable
1wsvB-2z23A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
3 / 3 ARG A 413
SER A 368
TYR A 273
None
1.01A 2q2hA-2z23A:
undetectable
2q2hB-2z23A:
undetectable
2q2hA-2z23A:
15.16
2q2hB-2z23A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
6 / 12 LEU A 374
ASP A 300
ILE A 301
GLY A 296
ALA A 377
ILE A 302
None
1.47A 2rkfB-2z23A:
undetectable
2rkfB-2z23A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 11 HIS A 508
ASN A  50
VAL A  48
SER A 165
HIS A 161
None
1.39A 2zweA-2z23A:
undetectable
2zweB-2z23A:
undetectable
2zweA-2z23A:
21.00
2zweB-2z23A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 11 HIS A 508
ASN A  50
VAL A  48
SER A 165
HIS A 161
None
1.37A 2zwfA-2z23A:
undetectable
2zwfB-2z23A:
undetectable
2zwfA-2z23A:
21.00
2zwfB-2z23A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 11 HIS A 508
ASN A  50
VAL A  48
SER A 165
HIS A 161
None
1.38A 2zwgA-2z23A:
undetectable
2zwgB-2z23A:
undetectable
2zwgA-2z23A:
21.00
2zwgB-2z23A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 112
SER A 434
VAL A 152
HIS A 117
None
1.17A 3b9lA-2z23A:
2.0
3b9lA-2z23A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
3 / 3 SER A 207
GLY A 189
GLY A 187
None
0.54A 3bogA-2z23A:
undetectable
3bogC-2z23A:
undetectable
3bogA-2z23A:
undetectable
3bogC-2z23A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 ASP A 122
GLN A 114
GLU A 150
GLU A 451
None
1.12A 3dh0A-2z23A:
undetectable
3dh0A-2z23A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.39A 3dqtA-2z23A:
undetectable
3dqtB-2z23A:
undetectable
3dqtA-2z23A:
19.61
3dqtB-2z23A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.37A 3jx1A-2z23A:
undetectable
3jx1B-2z23A:
undetectable
3jx1A-2z23A:
20.73
3jx1B-2z23A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
3 / 3 SER A 227
SER A 228
HIS A 371
None
0.82A 3mzeA-2z23A:
undetectable
3mzeA-2z23A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 SER A  21
TRP A 397
PHE A 400
GLU A 396
None
1.32A 3n5tA-2z23A:
undetectable
3n5tB-2z23A:
undetectable
3n5tA-2z23A:
19.46
3n5tB-2z23A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.37A 3nlyA-2z23A:
undetectable
3nlyB-2z23A:
undetectable
3nlyA-2z23A:
20.73
3nlyB-2z23A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
3 / 3 TYR A 210
ASP A 511
ASP A 502
None
0.86A 3ou6B-2z23A:
undetectable
3ou6B-2z23A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TRP A  97
LEU A 144
ILE A  76
GLY A  59
None
0.81A 3wxoA-2z23A:
undetectable
3wxoA-2z23A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 GLU A 422
TYR A 420
HIS A 161
VAL A  48
None
1.10A 4a97D-2z23A:
undetectable
4a97D-2z23A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 6 GLU A 422
TYR A 420
HIS A 161
VAL A  48
None
1.04A 4a97E-2z23A:
undetectable
4a97E-2z23A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.37A 4capA-2z23A:
undetectable
4capB-2z23A:
undetectable
4capA-2z23A:
20.73
4capB-2z23A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.38A 4d32A-2z23A:
undetectable
4d32B-2z23A:
undetectable
4d32A-2z23A:
20.73
4d32B-2z23A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.40A 4k5jA-2z23A:
undetectable
4k5jB-2z23A:
undetectable
4k5jA-2z23A:
19.31
4k5jB-2z23A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TYR A 245
ASP A 419
GLU A  32
ARG A  41
None
1.19A 4kr4C-2z23A:
undetectable
4kr4C-2z23A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 5 VAL A 146
LEU A 159
VAL A  48
PHE A  74
None
0.74A 4lb0B-2z23A:
undetectable
4lb0B-2z23A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.37A 4v3yA-2z23A:
undetectable
4v3yB-2z23A:
undetectable
4v3yA-2z23A:
20.73
4v3yB-2z23A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 12 LEU A 113
ALA A 116
LEU A 159
LEU A 158
LEU A 148
None
1.16A 4zn7A-2z23A:
undetectable
4zn7A-2z23A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.37A 5adlA-2z23A:
undetectable
5adlB-2z23A:
undetectable
5adlA-2z23A:
19.31
5adlB-2z23A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.41A 5fj3A-2z23A:
undetectable
5fj3B-2z23A:
undetectable
5fj3A-2z23A:
19.31
5fj3B-2z23A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 VAL A 152
TYR A 420
GLU A 422
LEU A 431
None
1.03A 5umwB-2z23A:
2.0
5umwE-2z23A:
1.9
5umwB-2z23A:
10.53
5umwE-2z23A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 LEU A 431
VAL A 152
TYR A 420
GLU A 422
None
1.09A 5umwA-2z23A:
undetectable
5umwF-2z23A:
2.0
5umwA-2z23A:
10.53
5umwF-2z23A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 SER A  21
TRP A 397
PHE A 400
GLU A 396
None
1.33A 5uo7A-2z23A:
undetectable
5uo7B-2z23A:
undetectable
5uo7A-2z23A:
21.11
5uo7B-2z23A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 6 SER A  21
TRP A 397
PHE A 400
GLU A 396
None
1.40A 5uo8A-2z23A:
0.0
5uo8B-2z23A:
0.0
5uo8A-2z23A:
20.97
5uo8B-2z23A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.41A 5vv7A-2z23A:
undetectable
5vv7B-2z23A:
undetectable
5vv7A-2z23A:
19.31
5vv7B-2z23A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.44A 5vvnA-2z23A:
undetectable
5vvnB-2z23A:
undetectable
5vvnA-2z23A:
19.31
5vvnB-2z23A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 8 ILE A 450
ASN A 437
PRO A 319
THR A 318
None
0.88A 5x23A-2z23A:
undetectable
5x23A-2z23A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 11 HIS A 508
ASN A  50
VAL A  48
SER A 165
HIS A 161
None
1.41A 5z0hA-2z23A:
undetectable
5z0hB-2z23A:
undetectable
5z0hA-2z23A:
16.23
5z0hB-2z23A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 11 HIS A 508
ASN A  50
VAL A  48
SER A 165
HIS A 161
None
1.42A 5z0iA-2z23A:
undetectable
5z0iB-2z23A:
undetectable
5z0iA-2z23A:
16.23
5z0iB-2z23A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 11 HIS A 508
ASN A  50
VAL A  48
SER A 165
HIS A 161
None
1.40A 5z0kA-2z23A:
undetectable
5z0kB-2z23A:
undetectable
5z0kA-2z23A:
16.23
5z0kB-2z23A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 11 HIS A 508
ASN A  50
VAL A  48
SER A 165
HIS A 161
None
1.40A 5z0lA-2z23A:
undetectable
5z0lB-2z23A:
undetectable
5z0lA-2z23A:
16.23
5z0lB-2z23A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 SER A  21
TRP A 397
PHE A 400
GLU A 396
None
1.42A 6av6A-2z23A:
undetectable
6av6B-2z23A:
undetectable
6av6A-2z23A:
9.66
6av6B-2z23A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 TRP A 397
PHE A 400
GLU A 396
SER A  21
None
1.40A 6av6C-2z23A:
undetectable
6av6D-2z23A:
undetectable
6av6C-2z23A:
9.66
6av6D-2z23A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 7 SER A  21
TRP A 397
PHE A 400
GLU A 396
None
1.46A 6av7A-2z23A:
undetectable
6av7B-2z23A:
undetectable
6av7A-2z23A:
9.66
6av7B-2z23A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 9 VAL A 509
HIS A 508
ASP A  42
LEU A 224
None
0.93A 6c2mD-2z23A:
undetectable
6c2mD-2z23A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
5 / 10 GLY A 497
ASP A 242
VAL A 203
GLU A 205
TYR A 191
None
1.47A 6cgdA-2z23A:
2.0
6cgdA-2z23A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia
pestis)
4 / 6 VAL A 152
LEU A 158
LEU A 159
LEU A 113
None
0.83A 6f6sA-2z23A:
undetectable
6f6sB-2z23A:
undetectable
6f6sA-2z23A:
10.47
6f6sB-2z23A:
9.45