SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		4 / 5 HIS A  16
HIS A 129
HIS A 167
ASP A 240
 ZN  A 338 (-3.4A)
ZN  A1337 (-3.1A)
ZN  A1337 (-3.2A)
ZN  A 338 (-2.7A)
 0.57A 1e9yB-2z2bA:
18.3		 1e9yB-2z2bA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 6 HIS A  16
HIS A  18
HIS A 129
HIS A 167
ASP A 240
 ZN  A 338 (-3.4A)
ZN  A 338 (-3.2A)
ZN  A1337 (-3.1A)
ZN  A1337 (-3.2A)
ZN  A 338 (-2.7A)
 0.57A 1fweC-2z2bA:
6.5		 1fweC-2z2bA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		3 / 3 GLY A  37
ASP A  13
SER A 286
 None
 0.67A 3brfA-2z2bA:
undetectable		 3brfA-2z2bA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		4 / 7 PHE A 146
VAL A 128
VAL A 163
LEU A 184
 None
 0.84A 3hs6B-2z2bA:
undetectable		 3hs6B-2z2bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		4 / 7 LEU A 116
LEU A  80
SER A  83
THR A  50
 None
KCX  A 102 ( 3.8A)
None
None
 0.83A 3lm8A-2z2bA:
undetectable
3lm8C-2z2bA:
undetectable		 3lm8A-2z2bA:
23.58
3lm8C-2z2bA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 12 ASP A 240
HIS A  16
HIS A  18
ALA A 256
CYH A 211
 ZN  A 338 (-2.7A)
ZN  A 338 (-3.4A)
ZN  A 338 (-3.2A)
None
None
 1.07A 3r2jC-2z2bA:
undetectable		 3r2jC-2z2bA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 12 CYH A 285
LEU A 237
LEU A 265
LYS A   6
ILE A 302
 None
 1.13A 3ut5B-2z2bA:
undetectable		 3ut5B-2z2bA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		4 / 4 PRO A 105
LEU A 212
HIS A 192
LEU A 193
 None
 1.50A 3vw7A-2z2bA:
undetectable		 3vw7A-2z2bA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		4 / 5 HIS A  16
HIS A 129
HIS A 167
ASP A 240
 ZN  A 338 (-3.4A)
ZN  A1337 (-3.1A)
ZN  A1337 (-3.2A)
ZN  A 338 (-2.7A)
 0.55A 4h9mA-2z2bA:
5.9		 4h9mA-2z2bA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		3 / 3 LEU A 295
PRO A 296
ARG A  59
 None
 0.59A 4klrB-2z2bA:
undetectable		 4klrB-2z2bA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 12 LEU A 127
LEU A 184
VAL A 235
MET A 151
ILE A 147
 KCX  A 102 ( 4.5A)
None
None
None
None
 1.10A 4ok1A-2z2bA:
undetectable		 4ok1A-2z2bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 6 HIS A  16
HIS A  18
HIS A 129
HIS A 167
ASP A 240
 ZN  A 338 (-3.4A)
ZN  A 338 (-3.2A)
ZN  A1337 (-3.1A)
ZN  A1337 (-3.2A)
ZN  A 338 (-2.7A)
 0.43A 4ubpC-2z2bA:
19.3		 4ubpC-2z2bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 12 ARG A 225
PHE A 281
THR A 270
ASN A 260
LEU A 237
 None
 1.36A 4z7fC-2z2bA:
undetectable		 4z7fC-2z2bA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		4 / 4 ASP A 240
HIS A 167
HIS A 129
HIS A  18
 ZN  A 338 (-2.7A)
ZN  A1337 (-3.2A)
ZN  A1337 (-3.1A)
ZN  A 338 (-3.2A)
 1.46A 5ncdD-2z2bA:
3.4		 5ncdD-2z2bA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 8 ASP A 240
HIS A 167
HIS A 129
PRO A 213
HIS A  18
 ZN  A 338 (-2.7A)
ZN  A1337 (-3.2A)
ZN  A1337 (-3.1A)
None
ZN  A 338 (-3.2A)
 1.41A 5nekB-2z2bA:
3.1		 5nekB-2z2bA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 12 VAL A   6
LEU A   7
ILE A 302
LEU A 265
ALA A 269
 None
 1.16A 6ajiA-2z2bA:
undetectable		 6ajiA-2z2bA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		5 / 12 VAL A 235
PHE A 272
SER A 230
GLU A 226
VAL A 271
 None
 1.01A 6bqgA-2z2bA:
undetectable		 6bqgA-2z2bA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2z2b DIHYDROOROTASE
(Escherichia
coli) 		4 / 9 PHE A 292
VAL A 164
LEU A 237
ASP A 240
 None
None
None
ZN  A 338 (-2.7A)
 0.91A 6c2mD-2z2bA:
undetectable		 6c2mD-2z2bA:
14.76