SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 7 ASP A  96
HIS A  94
GLY A 113
GLY A 114
 None
 0.96A 1ekjE-2z2iA:
undetectable
1ekjF-2z2iA:
undetectable		 1ekjE-2z2iA:
21.74
1ekjF-2z2iA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.97A 1hxwB-2z2iA:
undetectable		 1hxwB-2z2iA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.97A 2f80B-2z2iA:
undetectable		 2f80B-2z2iA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.91A 2qakB-2z2iA:
undetectable		 2qakB-2z2iA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.94A 2z54A-2z2iA:
undetectable		 2z54A-2z2iA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 8 VAL A  50
GLY A  53
THR A  52
GLY A  37
ALA A  38
 None
 1.28A 3aruA-2z2iA:
undetectable		 3aruA-2z2iA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  97
GLY A  25
LEU A  10
VAL A 150
ILE A 137
 None
 0.93A 3em6B-2z2iA:
undetectable		 3em6B-2z2iA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 120
GLY A 117
PRO A  65
ASN A  12
 None
 0.92A 3lslA-2z2iA:
undetectable
3lslD-2z2iA:
undetectable		 3lslA-2z2iA:
20.85
3lslD-2z2iA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A  65
ASN A  12
SER A 120
GLY A 117
 None
 0.86A 3lslA-2z2iA:
undetectable
3lslD-2z2iA:
undetectable		 3lslA-2z2iA:
20.85
3lslD-2z2iA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.94A 3oxwA-2z2iA:
undetectable		 3oxwA-2z2iA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 1.00A 3tkwA-2z2iA:
undetectable		 3tkwA-2z2iA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  21
PHE A 149
PRO A 146
 None
 0.68A 3zoaB-2z2iA:
undetectable		 3zoaB-2z2iA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.97A 4dqbB-2z2iA:
undetectable		 4dqbB-2z2iA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.98A 4dqeB-2z2iA:
undetectable		 4dqeB-2z2iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  47
ALA A  48
VAL A   8
GLY A  77
VAL A  61
 None
 0.97A 4dqhB-2z2iA:
undetectable		 4dqhB-2z2iA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 VAL A   8
VAL A  92
VAL A  85
GLY A  73
SER A  72
 None
 1.24A 4fwdA-2z2iA:
undetectable		 4fwdA-2z2iA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A  72
VAL A 133
PHE A 130
ALA A 124
LEU A   5
 None
 1.26A 4nc3A-2z2iA:
undetectable		 4nc3A-2z2iA:
19.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		6 / 9 HIS A  22
LEU A  97
GLY A 114
HIS A 115
VAL A 150
LEU A 151
 None
 0.52A 4qd3A-2z2iA:
26.8		 4qd3A-2z2iA:
37.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2z2i PEPTIDYL-TRNA
HYDROLASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 138
ARG A  21
GLU A 158
PHE A 154
 None
 0.98A 4r82A-2z2iA:
undetectable
4r82B-2z2iA:
undetectable		 4r82A-2z2iA:
21.05
4r82B-2z2iA:
21.05