SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 ALA A 225
ARG A 250
ILE A 230
ILE A 206
THR A 222
 None
 1.18A 1d1gB-2z2nA:
undetectable		 1d1gB-2z2nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		4 / 6 ASP A 151
ARG A 166
ASP A 172
THR A 174
 None
 1.16A 2j2pE-2z2nA:
undetectable
2j2pF-2z2nA:
undetectable		 2j2pE-2z2nA:
21.97
2j2pF-2z2nA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z2P_B_DOLB2003_1
(VIRGINIAMYCIN B
LYASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 10 LYS A  34
TRP A 243
GLY A 244
SER A 266
GLU A 268
 None
 0.98A 2z2pA-2z2nA:
51.3
2z2pB-2z2nA:
51.3		 2z2pA-2z2nA:
98.33
2z2pB-2z2nA:
98.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 None
 1.00A 3ou6A-2z2nA:
undetectable		 3ou6A-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 None
 1.00A 3ou6B-2z2nA:
undetectable		 3ou6B-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 None
 1.01A 3ou6C-2z2nA:
undetectable		 3ou6C-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 None
 1.02A 3ou7A-2z2nA:
undetectable		 3ou7A-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 None
 1.00A 3ou7B-2z2nA:
undetectable		 3ou7B-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 None
 0.96A 3ou7C-2z2nA:
undetectable		 3ou7C-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
 None
 1.03A 3ou7D-2z2nA:
undetectable		 3ou7D-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 LEU A  52
TYR A  50
LYS A  25
GLY A  68
GLY A  19
 None
 1.00A 4blvA-2z2nA:
undetectable		 4blvA-2z2nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 10 SER A 183
GLY A 184
ILE A 178
ILE A 209
ILE A 164
 None
 1.07A 4dt8B-2z2nA:
undetectable		 4dt8B-2z2nA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 TYR A 102
ILE A  20
GLY A  19
HIS A 228
ILE A 272
 None
 1.09A 4rvdA-2z2nA:
undetectable		 4rvdA-2z2nA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 VAL A  22
MET A  37
TYR A  50
ALA A  35
ASP A 286
 None
 1.40A 5fhqA-2z2nA:
undetectable		 5fhqA-2z2nA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		4 / 6 ILE A 272
GLY A 191
ASN A 192
ILE A 230
 None
 0.97A 5j4nB-2z2nA:
undetectable		 5j4nB-2z2nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		3 / 3 TYR A 134
SER A 170
TRP A 113
 None
None
CL  A 300 (-4.4A)
 0.98A 5n8jB-2z2nA:
undetectable		 5n8jB-2z2nA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		3 / 3 TYR A 134
SER A 170
TRP A 113
 None
None
CL  A 300 (-4.4A)
 0.98A 5n8jA-2z2nA:
undetectable		 5n8jA-2z2nA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		3 / 3 TYR A 134
SER A 170
TRP A 113
 None
None
CL  A 300 (-4.4A)
 0.97A 5n8jD-2z2nA:
undetectable		 5n8jD-2z2nA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		4 / 8 PHE A 156
ILE A 188
PRO A 179
PRO A 185
 None
 1.16A 5x23A-2z2nA:
undetectable		 5x23A-2z2nA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		4 / 8 PHE A 198
ILE A 230
PRO A 221
PRO A 227
 None
 1.09A 5x23A-2z2nA:
undetectable		 5x23A-2z2nA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		5 / 12 PHE A 198
GLY A 207
ILE A 272
GLY A 187
ALA A 232
 None
 1.00A 6c2mA-2z2nA:
undetectable		 6c2mA-2z2nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		4 / 6 ASN A  78
ASN A  96
PRO A  97
GLU A 133
 None
 0.96A 6h7uA-2z2nA:
undetectable		 6h7uA-2z2nA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2z2n VIRGINIAMYCIN B
LYASE
(Staphylococcus
aureus) 		4 / 8 ASN A  78
ASN A  96
PRO A  97
GLU A 133
 None
 1.06A 6hzpA-2z2nA:
undetectable		 6hzpA-2z2nA:
18.65