SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.19A 1m8eB-2z2rA:
undetectable		 1m8eB-2z2rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.13A 1nodB-2z2rA:
undetectable		 1nodB-2z2rA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.04A 1qomA-2z2rA:
undetectable		 1qomA-2z2rA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 190
LEU A 196
VAL A 199
ILE A 344
LEU A 231
 None
 1.08A 1s19A-2z2rA:
undetectable		 1s19A-2z2rA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 233
LEU A 193
PHE A 316
SER A 311
 None
 1.23A 1wrkB-2z2rA:
undetectable		 1wrkB-2z2rA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 233
LEU A 193
PHE A 316
SER A 311
 None
 1.04A 1wrlC-2z2rA:
undetectable
1wrlD-2z2rA:
undetectable		 1wrlC-2z2rA:
15.79
1wrlD-2z2rA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 267
PHE A 253
THR A 251
GLU A 270
 None
 1.41A 2dttB-2z2rA:
undetectable
2dttC-2z2rA:
undetectable		 2dttB-2z2rA:
19.84
2dttC-2z2rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.16A 2nodB-2z2rA:
undetectable		 2nodB-2z2rA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.33A 2y69C-2z2rA:
undetectable
2y69J-2z2rA:
undetectable		 2y69C-2z2rA:
19.03
2y69J-2z2rA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.38A 3abmC-2z2rA:
undetectable
3abmJ-2z2rA:
undetectable		 3abmC-2z2rA:
19.03
3abmJ-2z2rA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.37A 3abmP-2z2rA:
undetectable
3abmW-2z2rA:
2.5		 3abmP-2z2rA:
19.03
3abmW-2z2rA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.32A 3ag3C-2z2rA:
undetectable
3ag3J-2z2rA:
undetectable		 3ag3C-2z2rA:
19.03
3ag3J-2z2rA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.16A 3e6tB-2z2rA:
undetectable		 3e6tB-2z2rA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.00A 3e7iB-2z2rA:
undetectable		 3e7iB-2z2rA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.09A 3nw2B-2z2rA:
undetectable		 3nw2B-2z2rA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 254
THR A 251
TYR A 266
TYR A 252
 None
 1.31A 3wipG-2z2rA:
undetectable
3wipH-2z2rA:
undetectable		 3wipG-2z2rA:
20.67
3wipH-2z2rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 314
VAL A 283
THR A 202
ILE A 203
 None
 1.37A 4retA-2z2rA:
2.2		 4retA-2z2rA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 314
VAL A 283
THR A 202
ILE A 203
 None
 1.37A 4retC-2z2rA:
2.1		 4retC-2z2rA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 266
LEU A 222
GLY A 228
PHE A 253
 None
 0.83A 5kmdC-2z2rA:
undetectable
5kmdD-2z2rA:
undetectable		 5kmdC-2z2rA:
20.86
5kmdD-2z2rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.31A 5wauC-2z2rA:
undetectable
5wauJ-2z2rA:
undetectable		 5wauC-2z2rA:
19.03
5wauJ-2z2rA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.32A 5wauc-2z2rA:
undetectable
5wauj-2z2rA:
undetectable		 5wauc-2z2rA:
19.03
5wauj-2z2rA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z2r NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.33A 5xdqC-2z2rA:
undetectable
5xdqJ-2z2rA:
undetectable		 5xdqC-2z2rA:
19.03
5xdqJ-2z2rA:
12.32