SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 100
ASP A  18
MET A 108
LEU A 126
 None
 1.12A 1errB-2z2uA:
undetectable		 1errB-2z2uA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 183
GLY A 197
TRP A 202
TYR A 186
 None
 0.83A 1fapB-2z2uA:
undetectable		 1fapB-2z2uA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A 294
ASP A 291
ASN A  38
 None
 0.69A 2bm9D-2z2uA:
2.5		 2bm9D-2z2uA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 100
ASP A  18
MET A 108
LEU A 126
 None
 1.09A 2qxsB-2z2uA:
undetectable		 2qxsB-2z2uA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A 268
GLU A 272
ASP A 271
SER A 251
 None
 1.29A 3dzgA-2z2uA:
undetectable		 3dzgA-2z2uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 7 LEU A 268
GLU A 272
ASP A 271
SER A 251
 None
 1.32A 3dzgB-2z2uA:
undetectable		 3dzgB-2z2uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A 132
ILE A 133
PRO A 139
PRO A  57
 None
 0.87A 3fxrA-2z2uA:
undetectable		 3fxrA-2z2uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  25
THR A 159
HIS A 153
ILE A 149
VAL A  23
 None
 1.29A 3sp9A-2z2uA:
undetectable		 3sp9A-2z2uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  25
THR A 159
HIS A 153
ILE A 149
VAL A  23
 None
 1.28A 3sp9B-2z2uA:
undetectable		 3sp9B-2z2uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 161
ILE A 174
ILE A 151
VAL A 131
ILE A 133
 None
 0.86A 4dqbA-2z2uA:
undetectable		 4dqbA-2z2uA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A 273
TYR A  45
PHE A 160
LEU A 311
TYR A 180
 None
 1.30A 4j03A-2z2uA:
undetectable		 4j03A-2z2uA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 8 TRP A  61
TRP A  89
TYR A 142
THR A  56
 None
 1.28A 5tzoA-2z2uA:
undetectable		 5tzoA-2z2uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 8 TRP A  61
TRP A  89
TYR A 142
THR A  56
 None
 1.33A 5tzoB-2z2uA:
undetectable		 5tzoB-2z2uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		4 / 8 TRP A  61
TRP A  89
TYR A 142
THR A  56
 None
 1.27A 5tzoC-2z2uA:
undetectable		 5tzoC-2z2uA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 2z2u UPF0026 PROTEIN
MJ0257
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 161
ILE A 174
ILE A 151
VAL A 131
ILE A 133
 None
 0.96A 6dj2A-2z2uA:
undetectable		 6dj2A-2z2uA:
15.26