SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		3 / 3 PHE A 299
TRP A 366
GLU A 368
 None
 1.15A 1mogA-2z2wA:
undetectable		 1mogA-2z2wA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 8 LEU A 503
ILE A 432
GLY A 413
HIS A 418
 None
 0.76A 1sv9A-2z2wA:
undetectable		 1sv9A-2z2wA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 LEU A 406
ALA A 510
ILE A 388
HIS A 424
ILE A 461
 None
CSO  A 509 (-3.8A)
GOL  A 902 (-3.5A)
None
None
 0.90A 1tw4A-2z2wA:
undetectable		 1tw4A-2z2wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.58A 1uwhA-2z2wA:
23.6		 1uwhA-2z2wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.56A 1uwjA-2z2wA:
22.9		 1uwjA-2z2wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ILE A 305
VAL A 313
ALA A 326
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.78A 1uwjB-2z2wA:
22.7		 1uwjB-2z2wA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 LEU A 406
ALA A 510
ILE A 388
HIS A 424
ILE A 461
 None
CSO  A 509 (-3.8A)
GOL  A 902 (-3.5A)
None
None
 1.02A 2jn3A-2z2wA:
undetectable		 2jn3A-2z2wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
ILE A 374
TYR A 378
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.67A 2oiqA-2z2wA:
7.7		 2oiqA-2z2wA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 5 LEU A 503
ILE A 432
GLY A 413
HIS A 418
 None
 0.84A 2otfA-2z2wA:
undetectable		 2otfA-2z2wA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
VAL A 360
ILE A 374
TYR A 378
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
 0.87A 2pl0A-2z2wA:
22.5		 2pl0A-2z2wA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 GLY A 306
VAL A 313
ALA A 326
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.63A 2wgjA-2z2wA:
23.3		 2wgjA-2z2wA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 11 VAL A 313
ALA A 326
VAL A 360
TYR A 378
CYH A 379
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 ( 4.7A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
 0.50A 3g0eA-2z2wA:
21.6		 3g0eA-2z2wA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 6 VAL A 313
LYS A 328
VAL A 360
ILE A 374
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 ( 4.7A)
None
 0.78A 3mssD-2z2wA:
22.6		 3mssD-2z2wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
GLU A 346
VAL A 360
TYR A 378
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.48A 3oezA-2z2wA:
23.3		 3oezA-2z2wA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ILE A 305
VAL A 313
CYH A 379
PHE A 433
GLY A 465
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.73A 3og7A-2z2wA:
23.4		 3og7A-2z2wA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.78A 3og7A-2z2wA:
23.4		 3og7A-2z2wA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
GLU A 346
CYH A 379
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
 0.49A 3wzdA-2z2wA:
23.1		 3wzdA-2z2wA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 8 VAL A 359
VAL A 360
CYH A 379
ILE A 461
 None
770  A 901 ( 4.7A)
770  A 901 (-3.9A)
None
 0.46A 3wzeA-2z2wA:
23.4		 3wzeA-2z2wA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 8 VAL A 359
VAL A 360
ILE A 461
ASP A 463
 None
770  A 901 ( 4.7A)
None
770  A 901 (-3.8A)
 0.42A 3wzeA-2z2wA:
23.4		 3wzeA-2z2wA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 11 GLY A 306
VAL A 313
ALA A 326
TYR A 378
GLY A 382
SER A 383
 770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
None
 0.65A 4ckiA-2z2wA:
25.6		 4ckiA-2z2wA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		3 / 3 TYR A 295
ARG A 319
HIS A 300
 None
 0.80A 4fubA-2z2wA:
undetectable		 4fubA-2z2wA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
ASP A 386
ASP A 426
LYS A 428
ASN A 431
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
None
None
None
770  A 901 (-3.8A)
 0.60A 4i41A-2z2wA:
27.1		 4i41A-2z2wA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
VAL A 360
ILE A 374
TYR A 378
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.78A 4mxoA-2z2wA:
19.2		 4mxoA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.69A 4mxoA-2z2wA:
19.2		 4mxoA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
VAL A 360
ILE A 374
TYR A 378
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.87A 4mxoB-2z2wA:
19.1		 4mxoB-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
GLU A 346
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.83A 4mxyA-2z2wA:
20.7		 4mxyA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 VAL A 313
ALA A 326
GLU A 346
VAL A 360
ILE A 374
TYR A 378
GLY A 382
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
770  A 901 (-3.8A)
 0.83A 4mxzA-2z2wA:
20.7		 4mxzA-2z2wA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 8 ILE A 305
VAL A 313
ALA A 326
ASN A 431
ASP A 463
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-3.8A)
 0.58A 4ogrA-2z2wA:
26.6		 4ogrA-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 7 ALA A 326
CYH A 379
ASN A 431
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-3.8A)
 0.26A 4ogrE-2z2wA:
26.2		 4ogrE-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 9 ILE A 305
VAL A 313
ALA A 326
CYH A 379
ASN A 431
ASP A 463
 770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-3.8A)
 0.62A 4ogrI-2z2wA:
26.3		 4ogrI-2z2wA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ILE A 305
ALA A 326
LYS A 328
GLU A 346
ILE A 374
TYR A 378
ASP A 463
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.78A 4qmnA-2z2wA:
28.7		 4qmnA-2z2wA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 11 ILE A 305
ALA A 326
GLU A 346
ILE A 374
TYR A 378
ASP A 463
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.8A)
 0.68A 4qmsA-2z2wA:
28.6		 4qmsA-2z2wA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ALA A 326
ILE A 374
SER A 383
PHE A 433
GLY A 462
 770  A 901 (-3.5A)
None
None
770  A 901 (-4.0A)
None
 0.36A 4rzvA-2z2wA:
22.4		 4rzvA-2z2wA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 VAL A 313
ALA A 326
CYH A 379
SER A 383
PHE A 433
GLY A 462
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-4.0A)
None
None
 1.20A 4rzvB-2z2wA:
22.4		 4rzvB-2z2wA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 10 VAL A 313
GLU A 346
LEU A 353
VAL A 360
TYR A 378
ILE A 461
 770  A 901 ( 4.7A)
770  A 901 (-3.9A)
None
770  A 901 ( 4.7A)
770  A 901 (-4.2A)
None
 0.75A 4u0iA-2z2wA:
15.6		 4u0iA-2z2wA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
770  A 901 (-3.8A)
 0.66A 4xv2A-2z2wA:
23.0		 4xv2A-2z2wA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 ALA A 326
CYH A 379
PHE A 433
GLY A 462
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
770  A 901 (-3.8A)
 0.62A 4xv2B-2z2wA:
23.1		 4xv2B-2z2wA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.56A 5cswA-2z2wA:
22.8		 5cswA-2z2wA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
 0.57A 5cswB-2z2wA:
22.7		 5cswB-2z2wA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
ILE A 374
GLY A 382
GLY A 462
ASP A 463
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-3.4A)
None
770  A 901 (-3.8A)
 0.83A 5h2uB-2z2wA:
23.8		 5h2uB-2z2wA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
TYR A 378
ASP A 386
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.2A)
None
 0.54A 5hesA-2z2wA:
22.2		 5hesA-2z2wA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
ILE A 374
TYR A 378
ASP A 386
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.2A)
None
None
 0.98A 5hesB-2z2wA:
22.5		 5hesB-2z2wA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 ALA A 326
LYS A 328
GLU A 346
CYH A 379
HIS A 424
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
None
None
 0.90A 5hi2A-2z2wA:
23.5		 5hi2A-2z2wA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.0A)
None
 0.67A 5hieA-2z2wA:
4.3		 5hieA-2z2wA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.0A)
None
 0.69A 5hieB-2z2wA:
21.9		 5hieB-2z2wA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 12 VAL A 313
ALA A 326
ILE A 374
PHE A 433
GLY A 462
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
None
770  A 901 (-4.0A)
None
 0.67A 5hieD-2z2wA:
22.2		 5hieD-2z2wA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 ILE A 305
ALA A 326
LYS A 328
ILE A 374
TYR A 378
GLY A 382
 770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.67A 5i9xA-2z2wA:
24.2		 5i9xA-2z2wA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 7 GLY A 306
GLY A 308
VAL A 313
ASP A 463
 770  A 901 ( 4.6A)
None
770  A 901 ( 4.7A)
770  A 901 (-3.8A)
 0.48A 5j5xA-2z2wA:
19.1		 5j5xA-2z2wA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 GLU A 303
ILE A 305
GLY A 306
VAL A 313
ALA A 326
LYS A 328
GLU A 346
TYR A 378
 None
770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
 0.98A 5mafA-2z2wA:
28.0		 5mafA-2z2wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ILE A 305
GLY A 306
VAL A 313
ALA A 326
GLU A 346
TYR A 378
GLY A 382
 770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.60A 5mafA-2z2wA:
28.0		 5mafA-2z2wA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		5 / 10 VAL A 313
LYS A 328
GLU A 346
ILE A 374
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-3.4A)
 0.70A 5mo4A-2z2wA:
16.4		 5mo4A-2z2wA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 8 ALA A 326
GLU A 346
CYH A 379
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-3.8A)
 0.40A 5owrA-2z2wA:
23.1		 5owrA-2z2wA:
29.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 ALA A 326
GLU A 346
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
770  A 901 (-3.8A)
 0.77A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		8 / 12 ALA A 326
GLU A 346
TYR A 378
CYH A 379
GLY A 382
ASP A 386
PHE A 433
ASP A 463
 770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
None
770  A 901 (-4.0A)
770  A 901 (-3.8A)
 0.57A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		9 / 12 GLU A 303
ILE A 305
ALA A 326
GLU A 346
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.89A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		9 / 12 GLU A 303
ILE A 305
ALA A 326
GLU A 346
TYR A 378
CYH A 379
GLY A 382
ASP A 386
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
None
770  A 901 (-4.0A)
 0.80A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		9 / 12 GLU A 303
ILE A 305
GLY A 306
ALA A 326
ASN A 376
TYR A 378
CYH A 379
GLY A 382
PHE A 433
 None
770  A 901 (-3.8A)
770  A 901 ( 4.6A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.2A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.49A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		4 / 4 VAL A 313
LYS A 328
VAL A 360
ASN A 431
 770  A 901 ( 4.7A)
770  A 901 (-4.6A)
770  A 901 ( 4.7A)
None
 0.34A 5vc3A-2z2wA:
39.5		 5vc3A-2z2wA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		7 / 12 ALA A 326
LYS A 328
GLU A 346
VAL A 360
GLY A 382
PHE A 433
GLY A 462
 770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 ( 4.7A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
None
 0.94A 5vcvA-2z2wA:
32.2		 5vcvA-2z2wA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
CYH A 379
PHE A 433
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
 0.56A 5vcyA-2z2wA:
31.8		 5vcyA-2z2wA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens) 		6 / 12 VAL A 313
ALA A 326
LYS A 328
GLU A 346
GLY A 382
PHE A 433
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
770  A 901 (-4.0A)
 0.93A 5vcyA-2z2wA:
31.8		 5vcyA-2z2wA:
30.99