SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 8 THR A 323
ASN A 264
ASP A 379
GLY A 266
 MIS  A 324 ( 3.9A)
MIS  A 324 ( 3.0A)
CA  A1001 (-3.5A)
None
 0.99A 1bu5B-2z2xA:
2.1		 1bu5B-2z2xA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 6 PRO A  82
ASP A 315
ASP A 119
TYR A 317
 None
CA  A1007 (-2.9A)
CA  A1007 (-2.3A)
None
 1.31A 1hpkA-2z2xA:
undetectable		 1hpkA-2z2xA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.82A 1jnoA-2z2xA:
undetectable		 1jnoA-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.82A 1jnoB-2z2xA:
undetectable		 1jnoB-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.66A 1jo3A-2z2xA:
undetectable		 1jo3A-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.66A 1jo3B-2z2xA:
undetectable		 1jo3B-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.84A 1jo4A-2z2xA:
undetectable		 1jo4A-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.84A 1jo4B-2z2xA:
undetectable		 1jo4B-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.92A 1magA-2z2xA:
undetectable		 1magA-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.92A 1magB-2z2xA:
undetectable		 1magB-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.77A 1ng8A-2z2xA:
undetectable		 1ng8A-2z2xA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.77A 1ng8B-2z2xA:
undetectable		 1ng8B-2z2xA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.84A 1nrmA-2z2xA:
undetectable		 1nrmA-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.84A 1nrmB-2z2xA:
undetectable		 1nrmB-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.83A 1nruA-2z2xA:
undetectable		 1nruA-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.83A 1nruB-2z2xA:
undetectable		 1nruB-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 7 ALA A 227
ILE A 218
ILE A 348
GLU A 229
 CA  A1006 (-4.9A)
CA  A1004 (-4.9A)
None
CA  A1006 (-2.2A)
 0.92A 1oniD-2z2xA:
undetectable
1oniF-2z2xA:
1.1		 1oniD-2z2xA:
20.34
1oniF-2z2xA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 12 ILE A 291
LEU A 373
GLY A 374
VAL A 386
ALA A 370
 None
None
CA  A1001 ( 4.2A)
None
None
 1.13A 1tlsB-2z2xA:
undetectable		 1tlsB-2z2xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 9 GLY A 221
ALA A 220
GLU A 229
GLN A 110
TYR A 180
 None
None
CA  A1006 (-2.2A)
CA  A1006 (-3.0A)
None
 1.07A 2uy4A-2z2xA:
undetectable		 2uy4A-2z2xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 12 SER A 310
GLY A 117
GLY A 154
THR A 116
THR A 135
 None
 1.00A 2wa2B-2z2xA:
undetectable		 2wa2B-2z2xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 10 GLY A 221
ALA A 220
GLU A 229
GLN A 110
TYR A 180
 None
None
CA  A1006 (-2.2A)
CA  A1006 (-3.0A)
None
 1.04A 2xtkB-2z2xA:
undetectable		 2xtkB-2z2xA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 8 GLY A 305
GLY A  89
ILE A  90
THR A 160
 None
 0.64A 3d41A-2z2xA:
2.2		 3d41A-2z2xA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 12 GLY A 283
GLY A 385
ASP A 372
LEU A 373
ALA A 292
 None
None
CA  A1001 (-3.1A)
None
None
 0.88A 3ou6A-2z2xA:
2.3		 3ou6A-2z2xA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 12 THR A 327
GLY A 283
GLY A 322
GLU A 265
ALA A 275
 MIS  A 324 ( 4.5A)
None
MIS  A 324 ( 3.2A)
None
None
 1.07A 3t7vA-2z2xA:
2.3		 3t7vA-2z2xA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 LYS A 325
VAL A 157
HIS A 156
 MIS  A 324 ( 3.2A)
MIS  A 324 ( 4.5A)
None
 0.97A 3tj7A-2z2xA:
undetectable		 3tj7A-2z2xA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 12 ASP A 119
ASP A 124
HIS A 122
GLY A 169
TYR A 317
 CA  A1007 (-2.3A)
CA  A1002 (-2.2A)
None
CA  A1002 ( 4.4A)
None
 1.36A 4bz6A-2z2xA:
undetectable
4bz6B-2z2xA:
undetectable		 4bz6A-2z2xA:
20.66
4bz6B-2z2xA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 10 ALA A 227
ILE A 204
ILE A 200
LEU A 114
ILE A 231
 CA  A1006 (-4.9A)
None
None
None
None
 1.25A 4dtaA-2z2xA:
undetectable		 4dtaA-2z2xA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 7 VAL A 279
ALA A 260
MET A 233
ASP A 240
 None
 0.68A 4l9iA-2z2xA:
undetectable		 4l9iA-2z2xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		3 / 3 TYR A 180
GLY A 206
PRO A 207
 None
CA  A1005 ( 4.2A)
None
 0.55A 4qwpA-2z2xA:
undetectable		 4qwpA-2z2xA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 8 SER A 271
GLY A 283
ALA A 274
THR A 323
 None
None
None
MIS  A 324 ( 3.9A)
 0.98A 5ef3L-2z2xA:
undetectable
5ef3V-2z2xA:
undetectable		 5ef3L-2z2xA:
14.34
5ef3V-2z2xA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		4 / 6 ILE A 280
VAL A 387
TYR A 384
VAL A 301
 None
 0.99A 5jwaH-2z2xA:
2.4		 5jwaH-2z2xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2z2x TK-SUBTILISIN
(Thermococcus
kodakarensis) 		5 / 9 ILE A 248
LEU A 244
ILE A 200
ILE A 231
ALA A 261
 None
None
None
None
MIS  A 324 ( 3.7A)
 0.95A 5nunA-2z2xA:
undetectable		 5nunA-2z2xA:
13.89