SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 8 THR A 323
ASN A 264
ASP A 379
GLY A 266
 None
None
CA  A1006 (-3.0A)
None
 0.95A 1bu5B-2z2zA:
2.2		 1bu5B-2z2zA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.95A 1grmA-2z2zA:
undetectable		 1grmA-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.95A 1grmB-2z2zA:
undetectable		 1grmB-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 SER A 232
GLY A 332
GLY A  89
ALA A 326
VAL A 282
 None
 1.06A 1jg4A-2z2zA:
2.0		 1jg4A-2z2zA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.82A 1jnoA-2z2zA:
undetectable		 1jnoA-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.82A 1jnoB-2z2zA:
undetectable		 1jnoB-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.65A 1jo3A-2z2zA:
undetectable		 1jo3A-2z2zA:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.65A 1jo3B-2z2zA:
undetectable		 1jo3B-2z2zA:
3.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.82A 1jo4A-2z2zA:
undetectable		 1jo4A-2z2zA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.82A 1jo4B-2z2zA:
undetectable		 1jo4B-2z2zA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.91A 1magA-2z2zA:
undetectable		 1magA-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.91A 1magB-2z2zA:
undetectable		 1magB-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.77A 1ng8A-2z2zA:
undetectable		 1ng8A-2z2zA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.77A 1ng8B-2z2zA:
undetectable		 1ng8B-2z2zA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.81A 1nrmA-2z2zA:
undetectable		 1nrmA-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.81A 1nrmB-2z2zA:
undetectable		 1nrmB-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.81A 1nruA-2z2zA:
undetectable		 1nruA-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 ALA A 163
VAL A 173
TRP A  99
 None
 0.81A 1nruB-2z2zA:
undetectable		 1nruB-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 6 PRO A 304
HIS A 329
LEU A 309
SER A  73
 None
 1.12A 1sbrA-2z2zA:
undetectable
1sbrB-2z2zA:
undetectable		 1sbrA-2z2zA:
19.90
1sbrB-2z2zA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 ILE A 291
LEU A 373
GLY A 374
VAL A 386
ALA A 370
 None
None
CA  A1006 ( 4.5A)
None
None
 1.15A 1tlsB-2z2zA:
undetectable		 1tlsB-2z2zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 ALA A 380
ASP A 379
ILE A 291
GLY A 283
ALA A 267
 None
CA  A1006 (-3.0A)
None
None
None
 0.90A 2b60A-2z2zA:
undetectable		 2b60A-2z2zA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 HIS A 329
ILE A 161
LEU A 336
 None
 0.77A 2kceA-2z2zA:
undetectable		 2kceA-2z2zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 LEU A 309
ILE A 308
SER A  73
GLY A 172
LEU A 125
 None
 1.07A 2lbdA-2z2zA:
undetectable		 2lbdA-2z2zA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 SER A 234
SER A 232
SER A 331
VAL A 177
ALA A 174
 None
 1.21A 2nniA-2z2zA:
undetectable		 2nniA-2z2zA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 9 GLY A 221
ALA A 220
GLU A 229
GLN A 110
TYR A 180
 None
None
CA  A1001 (-2.2A)
CA  A1001 (-3.0A)
None
 1.07A 2uy4A-2z2zA:
undetectable		 2uy4A-2z2zA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 7 LEU A  35
ALA A 227
GLY A 206
PHE A  33
 None
CA  A1001 (-4.9A)
CA  A1003 ( 4.3A)
None
 0.89A 2wq5A-2z2zA:
undetectable		 2wq5A-2z2zA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 10 GLY A 221
ALA A 220
GLU A 229
GLN A 110
TYR A 180
 None
None
CA  A1001 (-2.2A)
CA  A1001 (-3.0A)
None
 1.04A 2xtkB-2z2zA:
2.3		 2xtkB-2z2zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 8 GLY A 305
GLY A  89
ILE A  90
THR A 160
 None
 0.64A 3d41A-2z2zA:
2.1		 3d41A-2z2zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 GLY A 199
THR A 135
ILE A 231
ARG A 183
LEU A 114
 None
 1.14A 3iv6D-2z2zA:
undetectable		 3iv6D-2z2zA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 GLY A 283
GLY A 385
ASP A 372
LEU A 373
ALA A 292
 None
None
CA  A1006 (-2.8A)
None
None
 0.83A 3ou6A-2z2zA:
undetectable		 3ou6A-2z2zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 5 ASP A 195
SER A 141
VAL A 140
GLY A 138
 None
 1.11A 3rxhA-2z2zA:
undetectable		 3rxhA-2z2zA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 9 ALA A 211
GLY A 217
ILE A 218
ILE A 256
ILE A 204
 None
None
CA  A1004 (-4.8A)
None
None
 0.95A 3s43A-2z2zA:
undetectable		 3s43A-2z2zA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 11 GLY A 255
ALA A 254
ILE A 249
ILE A 200
ILE A 204
 None
 0.99A 3s45B-2z2zA:
undetectable		 3s45B-2z2zA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 SER A 310
ASP A 149
ASP A 186
 None
 0.80A 3uj7A-2z2zA:
2.6		 3uj7A-2z2zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 6 ASP A 286
GLY A 305
VAL A 306
TRP A  88
 None
 1.24A 3vqrA-2z2zA:
undetectable		 3vqrA-2z2zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 ILE A 248
VAL A 279
ILE A 256
THR A 327
ILE A 200
 None
 1.26A 3vrjA-2z2zA:
undetectable
3vrjC-2z2zA:
undetectable		 3vrjA-2z2zA:
20.68
3vrjC-2z2zA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 TRP A 131
VAL A 133
LEU A 136
VAL A  30
VAL A  40
 None
 1.01A 3w68B-2z2zA:
undetectable		 3w68B-2z2zA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 ASP A 119
ASP A 124
HIS A 122
GLY A 169
TYR A 317
 CA  A1002 (-2.3A)
CA  A1007 (-2.2A)
None
CA  A1007 ( 4.4A)
None
 1.37A 4bz6A-2z2zA:
2.1
4bz6B-2z2zA:
undetectable		 4bz6A-2z2zA:
22.04
4bz6B-2z2zA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 GLU A 229
ASP A 222
ASP A 224
ASP A 208
GLN A 178
 CA  A1001 (-2.2A)
CA  A1005 ( 2.2A)
CA  A1005 (-3.3A)
CA  A1003 (-2.7A)
None
 1.48A 4djeB-2z2zA:
2.6		 4djeB-2z2zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 7 GLY A 255
ILE A 348
GLU A 229
GLN A 250
 None
None
CA  A1001 (-2.2A)
None
 1.09A 4g0vA-2z2zA:
undetectable		 4g0vA-2z2zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 7 VAL A 279
ALA A 260
MET A 233
ASP A 240
 None
 0.52A 4l9iA-2z2zA:
undetectable		 4l9iA-2z2zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 6 ASP A 214
ASP A 225
ALA A 220
ASP A 216
 CA  A1005 ( 2.7A)
CA  A1004 (-3.2A)
None
CA  A1004 ( 2.9A)
 1.16A 4mdaA-2z2zA:
undetectable		 4mdaA-2z2zA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 6 ASP A 214
ASP A 225
ALA A 220
ASP A 216
 CA  A1005 ( 2.7A)
CA  A1004 (-3.2A)
None
CA  A1004 ( 2.9A)
 1.21A 4mdbA-2z2zA:
undetectable		 4mdbA-2z2zA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 ALA A 389
GLY A 332
THR A 160
THR A 319
GLY A  89
 None
 1.21A 4n48B-2z2zA:
undetectable		 4n48B-2z2zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		4 / 8 ALA A 211
GLY A 209
LEU A 205
LEU A  35
 None
 0.89A 4po0A-2z2zA:
undetectable		 4po0A-2z2zA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		3 / 3 TYR A 180
GLY A 206
PRO A 207
 None
CA  A1003 ( 4.3A)
None
 0.47A 4qwpA-2z2zA:
undetectable		 4qwpA-2z2zA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 10 HIS A 153
LEU A 185
ALA A 274
ALA A 324
GLY A 236
 None
 1.26A 4rn6A-2z2zA:
undetectable		 4rn6A-2z2zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 HIS A 153
GLY A  70
VAL A 387
GLY A 263
LEU A  68
 None
 1.05A 5hg0A-2z2zA:
undetectable		 5hg0A-2z2zA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 HIS A 153
GLY A  70
VAL A 387
GLY A 263
LEU A  68
 None
 1.08A 5hg0B-2z2zA:
undetectable		 5hg0B-2z2zA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 GLY A  70
SER A 234
MET A 325
THR A 116
TYR A 312
 None
 1.38A 5yf0A-2z2zA:
undetectable		 5yf0A-2z2zA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 2z2z TK-SUBTILISIN
PRECURSOR
(Thermococcus
kodakarensis) 		5 / 12 GLY A 237
SER A 271
ALA A 261
ALA A 260
VAL A 259
 None
 1.06A 6c2mC-2z2zA:
undetectable		 6c2mC-2z2zA:
11.43