SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		3 / 3 VAL A 317
VAL A 319
TRP A  49
 None
 0.99A 1bdwA-2z36A:
undetectable
1bdwB-2z36A:
undetectable		 1bdwA-2z36A:
3.22
1bdwB-2z36A:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 LEU A 285
GLY A 260
VAL A 405
LEU A 382
LEU A 403
 None
 0.94A 1mx1D-2z36A:
undetectable		 1mx1D-2z36A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 6 GLU A 365
LEU A 361
LEU A 164
GLY A 165
 None
HEM  A 450 ( 4.9A)
None
None
 0.94A 1n13H-2z36A:
undetectable
1n13K-2z36A:
undetectable		 1n13H-2z36A:
12.71
1n13K-2z36A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 9 LEU A 382
GLU A 402
HIS A 401
GLU A 248
LEU A 153
 None
 1.27A 2azqA-2z36A:
0.0		 2azqA-2z36A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 LEU A 243
ILE A 160
PHE A 217
VAL A 166
GLY A 165
 None
 1.14A 2bxeB-2z36A:
undetectable		 2bxeB-2z36A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 6 ASP A  99
SER A  67
LEU A  96
GLY A  97
 None
None
HEM  A 450 ( 4.2A)
None
 1.04A 2j2pA-2z36A:
undetectable
2j2pC-2z36A:
undetectable		 2j2pA-2z36A:
19.37
2j2pC-2z36A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 8 LEU A 285
PRO A  21
VAL A 400
GLY A 399
 None
 1.08A 2qd5B-2z36A:
undetectable		 2qd5B-2z36A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 LEU A 241
LEU A 238
LEU A 235
GLN A 224
LEU A 357
 HEM  A 450 ( 4.9A)
None
None
None
HEM  A 450 ( 4.0A)
 1.48A 2w8yB-2z36A:
2.7		 2w8yB-2z36A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 THR A 249
GLY A 399
LEU A 256
LEU A 322
ASN A 325
 HEM  A 450 ( 3.7A)
None
None
None
None
 1.00A 2zw9B-2z36A:
undetectable		 2zw9B-2z36A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 LEU A 241
LEU A 238
LEU A 235
GLN A 224
LEU A 357
 HEM  A 450 ( 4.9A)
None
None
None
HEM  A 450 ( 4.0A)
 1.47A 3d90A-2z36A:
2.7		 3d90A-2z36A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		3 / 3 ALA A 245
THR A 249
CYH A 356
 HEM  A 450 ( 3.9A)
HEM  A 450 ( 3.7A)
HEM  A 450 ( 2.6A)
 0.52A 3e4eA-2z36A:
29.2		 3e4eA-2z36A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		3 / 3 ALA A 245
THR A 249
CYH A 356
 HEM  A 450 ( 3.9A)
HEM  A 450 ( 3.7A)
HEM  A 450 ( 2.6A)
 0.44A 3e4eB-2z36A:
29.2		 3e4eB-2z36A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 GLY A  53
ASP A 327
PRO A 328
ALA A 329
ILE A  37
 None
 0.98A 3jb1A-2z36A:
undetectable		 3jb1A-2z36A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 GLY A 165
ARG A 219
LEU A 242
THR A 178
PHE A 174
 None
None
HEM  A 450 ( 4.1A)
None
None
 1.50A 3mneA-2z36A:
undetectable		 3mneA-2z36A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 8 ARG A  18
VAL A 295
TYR A 398
ILE A 397
 None
MES  A4574 ( 4.0A)
None
None
 0.99A 3remA-2z36A:
1.4		 3remA-2z36A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 8 ARG A  18
VAL A 295
TYR A 398
ILE A 397
 None
MES  A4574 ( 4.0A)
None
None
 0.97A 3remB-2z36A:
1.4		 3remB-2z36A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 7 ILE A 134
LEU A 151
MET A 253
GLY A 257
 None
 1.00A 4hajA-2z36A:
undetectable		 4hajA-2z36A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 8 PHE A 174
LEU A 197
LEU A 164
PHE A 217
 None
 0.87A 4qopC-2z36A:
undetectable		 4qopC-2z36A:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 7 LEU A  96
THR A 249
ALA A 292
ARG A 298
ILE A 397
 HEM  A 450 ( 4.2A)
HEM  A 450 ( 3.7A)
HEM  A 450 ( 4.0A)
HEM  A 450 ( 3.3A)
None
 0.57A 4ubsA-2z36A:
48.7		 4ubsA-2z36A:
50.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		3 / 3 GLN A 367
THR A 278
ASP A 371
 None
 0.94A 5k9dA-2z36A:
undetectable		 5k9dA-2z36A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 12 VAL A 304
ASP A 303
GLU A 302
GLY A 314
LEU A 299
 None
 1.30A 5ogcB-2z36A:
undetectable		 5ogcB-2z36A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		5 / 8 VAL A 304
ASP A 303
GLU A 302
GLY A 314
LEU A 299
 None
 1.40A 5w3jB-2z36A:
undetectable		 5w3jB-2z36A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		4 / 5 HIS A 401
SER A 395
GLY A 393
TYR A 398
 None
 1.11A 5yodB-2z36A:
undetectable		 5yodB-2z36A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2z36 CYTOCHROME P450 TYPE
COMPACTIN
3'',4''-HYDROXYLASE
(Nonomuraea
recticatena) 		3 / 3 LEU A 361
GLY A 246
PHE A 174
 HEM  A 450 ( 4.9A)
HEM  A 450 ( 3.4A)
None
 0.66A 6exiC-2z36A:
undetectable		 6exiC-2z36A:
13.23