SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 8 LEU A 111
ALA A  10
GLY A  21
ILE A 102
 None
 0.69A 1d4yB-2z3bA:
undetectable		 1d4yB-2z3bA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		5 / 10 GLU A 154
GLU A 178
ALA A  18
LEU A 176
ALA A 156
 None
 1.22A 1mjqG-2z3bA:
undetectable
1mjqH-2z3bA:
undetectable		 1mjqG-2z3bA:
17.58
1mjqH-2z3bA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 6 ARG A 140
ILE A 125
GLY A 139
ALA A 138
 None
 0.97A 1wmqA-2z3bA:
undetectable		 1wmqA-2z3bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 6 ARG A 140
ILE A 125
GLY A 139
ALA A 138
 None
 0.98A 1wmqB-2z3bA:
undetectable		 1wmqB-2z3bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 6 ARG A 140
ILE A 125
GLY A 139
ALA A 138
 None
 0.97A 1wpuA-2z3bA:
undetectable		 1wpuA-2z3bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 6 ARG A 140
ILE A 125
GLY A 139
ALA A 138
 None
 0.97A 1wpuB-2z3bA:
undetectable		 1wpuB-2z3bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 6 ARG A 140
ILE A 125
GLY A 139
ALA A 138
 None
 1.00A 1wrqA-2z3bA:
undetectable		 1wrqA-2z3bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 6 ARG A 140
ILE A 125
GLY A 139
ALA A 138
 None
 1.01A 1wrqB-2z3bA:
undetectable		 1wrqB-2z3bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		5 / 12 ALA A 135
TYR A 134
GLY A 132
ILE A 125
ASP A 123
 None
 1.06A 2qe6B-2z3bA:
undetectable		 2qe6B-2z3bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		5 / 9 THR A 162
GLU A 161
GLY A 139
GLU A 154
ILE A 155
 None
 1.35A 2w98A-2z3bA:
undetectable		 2w98A-2z3bA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		6 / 12 LEU A 160
ILE A 174
ILE A 175
ALA A  18
ILE A 102
VAL A  40
 None
 1.28A 4nkxA-2z3bA:
undetectable		 4nkxA-2z3bA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 5 GLU A  83
LYS A  86
GLU A  87
GLU A  72
 None
 1.40A 5onlA-2z3bA:
undetectable		 5onlA-2z3bA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.75A 5vkqA-2z3bA:
undetectable
5vkqD-2z3bA:
undetectable		 5vkqA-2z3bA:
9.12
5vkqD-2z3bA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.74A 5vkqA-2z3bA:
undetectable
5vkqB-2z3bA:
undetectable		 5vkqA-2z3bA:
9.12
5vkqB-2z3bA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.74A 5vkqB-2z3bA:
undetectable
5vkqC-2z3bA:
undetectable		 5vkqB-2z3bA:
9.12
5vkqC-2z3bA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 5 LEU A  77
LYS A  78
ALA A  81
LEU A  84
 None
 0.74A 5vkqC-2z3bA:
undetectable
5vkqD-2z3bA:
undetectable		 5vkqC-2z3bA:
9.12
5vkqD-2z3bA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		3 / 3 LYS A  65
LEU A  97
ASP A  91
 None
 0.90A 5zv2A-2z3bA:
undetectable		 5zv2A-2z3bA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 2z3b ATP-DEPENDENT
PROTEASE HSLV
(Bacillus
subtilis) 		4 / 5 GLU A  83
LYS A  86
GLU A  87
GLU A  72
 None
 1.41A 6hrjA-2z3bA:
0.0		 6hrjA-2z3bA:
24.43