SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.06A 1c8lA-2z3kA:
undetectable		 1c8lA-2z3kA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.07A 1gfzA-2z3kA:
undetectable		 1gfzA-2z3kA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A  38
SER A  34
ASP A  32
TRP A  58
 None
 0.99A 1ismB-2z3kA:
undetectable		 1ismB-2z3kA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A   6
LEU A  57
LEU A   3
GLN A   5
 None
 1.07A 1kt3A-2z3kA:
undetectable		 1kt3A-2z3kA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A 132
LEU A 170
HIS A  82
GLY A 142
SER A 160
 None
None
None
None
TAR  A 501 ( 2.6A)
 1.48A 1kyvA-2z3kA:
undetectable
1kyvB-2z3kA:
undetectable		 1kyvA-2z3kA:
22.36
1kyvB-2z3kA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.05A 1l5qA-2z3kA:
undetectable		 1l5qA-2z3kA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.10A 1l5qB-2z3kA:
undetectable		 1l5qB-2z3kA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.05A 1l7xA-2z3kA:
undetectable		 1l7xA-2z3kA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.06A 1l7xB-2z3kA:
undetectable		 1l7xB-2z3kA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		5 / 12 ARG A  80
SER A 160
VAL A 141
TYR A  87
VAL A 134
 None
TAR  A 501 ( 2.6A)
None
None
None
 1.50A 1x70B-2z3kA:
undetectable		 1x70B-2z3kA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		5 / 12 SER A  75
ARG A  80
SER A 160
VAL A 141
TYR A  87
 None
None
TAR  A 501 ( 2.6A)
None
None
 1.42A 1x70B-2z3kA:
undetectable		 1x70B-2z3kA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 ILE A 202
ARG A  64
LEU A 184
ASP A 186
 None
 1.00A 2rlfA-2z3kA:
undetectable
2rlfD-2z3kA:
undetectable		 2rlfA-2z3kA:
14.29
2rlfD-2z3kA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 5 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.07A 3bcrA-2z3kA:
undetectable		 3bcrA-2z3kA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.05A 3dd1A-2z3kA:
undetectable		 3dd1A-2z3kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.06A 3dd1B-2z3kA:
undetectable		 3dd1B-2z3kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.08A 3ddsA-2z3kA:
undetectable		 3ddsA-2z3kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.07A 3ddsB-2z3kA:
undetectable		 3ddsB-2z3kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.08A 3ddwA-2z3kA:
undetectable		 3ddwA-2z3kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 6 PHE A  47
ALA A  41
GLY A  45
TYR A  42
 None
 1.07A 3ddwB-2z3kA:
undetectable		 3ddwB-2z3kA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 5 LEU A 219
ALA A 148
PHE A 153
ASN A  92
 None
 1.24A 3uq6A-2z3kA:
undetectable		 3uq6A-2z3kA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 4 LEU A 219
ALA A 148
PHE A 153
ASN A  92
 None
 1.30A 3vaqA-2z3kA:
undetectable		 3vaqA-2z3kA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 4 LEU A 219
ALA A 148
PHE A 153
ASN A  92
 None
 1.24A 3vasA-2z3kA:
undetectable		 3vasA-2z3kA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.72A 4a97C-2z3kA:
undetectable		 4a97C-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.79A 4a97D-2z3kA:
undetectable		 4a97D-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.80A 4a97G-2z3kA:
undetectable		 4a97G-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A  87
VAL A  89
MET A 144
ILE A 132
 None
None
PHE  A 302 ( 3.6A)
None
 0.86A 4a97I-2z3kA:
undetectable		 4a97I-2z3kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A  38
PRO A  48
LEU A 123
TYR A 120
 None
 0.98A 4z4fA-2z3kA:
undetectable		 4z4fA-2z3kA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A  38
PRO A  48
LEU A 123
TYR A 120
 None
 1.03A 5t7bA-2z3kA:
undetectable		 5t7bA-2z3kA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 4 LEU A  72
LEU A  67
SER A 196
ALA A 199
 None
 0.94A 5uunA-2z3kA:
undetectable		 5uunA-2z3kA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		4 / 4 GLY A 142
LEU A 140
VAL A  98
GLU A 133
 None
 1.33A 5yw0A-2z3kA:
undetectable		 5yw0A-2z3kA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMM_A_SALA303_0
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2z3k LEUCYL/PHENYLALANYL-
TRNA-PROTEIN
TRANSFERASE
(Escherichia
coli) 		5 / 9 HIS A 193
SER A 160
ASN A 164
LEU A 170
LEU A 197
 XYA  A 301 ( 4.2A)
TAR  A 501 ( 2.6A)
TAR  A 501 ( 4.6A)
None
None
 1.38A 6emmA-2z3kA:
0.0		 6emmA-2z3kA:
19.21