SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 5 THR A 187
THR A 188
GLU A 257
THR A 253
 None
None
IMD  A 501 (-3.5A)
None
 1.29A 1d4fB-2z3tA:
undetectable		 1d4fB-2z3tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 7 ARG A  30
PHE A  51
VAL A  25
ALA A  32
 None
 1.09A 1fo4B-2z3tA:
undetectable		 1fo4B-2z3tA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 8 SER A 203
ALA A 202
GLY A 195
ALA A 201
 None
 0.74A 1gtnI-2z3tA:
undetectable
1gtnJ-2z3tA:
undetectable		 1gtnI-2z3tA:
8.41
1gtnJ-2z3tA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 11 LEU A 388
LEU A 378
LEU A 294
LEU A 148
LEU A 381
 None
 1.32A 1mx1B-2z3tA:
undetectable		 1mx1B-2z3tA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 12 ASN A 178
ALA A 179
GLN A 183
ARG A 189
LEU A  90
 None
 1.45A 1ya3B-2z3tA:
undetectable		 1ya3B-2z3tA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 12 ASN A 178
ALA A 179
GLN A 183
ARG A 189
LEU A  90
 None
 1.50A 2aa6B-2z3tA:
undetectable		 2aa6B-2z3tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		7 / 12 GLY A 377
LEU A 263
LEU A 156
GLY A 255
CYH A 364
ALA A 370
ALA A 367
 None
None
None
HEM  A 500 (-3.6A)
HEM  A 500 (-2.5A)
HEM  A 500 (-3.6A)
None
 1.47A 2bm9F-2z3tA:
undetectable		 2bm9F-2z3tA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 7 THR A 260
HIS A 256
GLY A 151
ASP A 147
 None
 0.94A 2ddwB-2z3tA:
undetectable		 2ddwB-2z3tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 7 ARG A 271
LEU A 268
PRO A 155
VAL A 149
 None
 1.35A 2hrcA-2z3tA:
undetectable		 2hrcA-2z3tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 4 LEU A 268
THR A 269
ILE A  19
HIS A 404
 None
 1.33A 2jfaB-2z3tA:
undetectable		 2jfaB-2z3tA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 12 ASN A 178
ALA A 179
GLN A 183
ARG A 189
LEU A  90
 None
 1.42A 2oaxD-2z3tA:
undetectable		 2oaxD-2z3tA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 LEU A 156
PRO A 155
LEU A 159
 None
 0.52A 2po5B-2z3tA:
undetectable		 2po5B-2z3tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 LEU A 156
PRO A 155
LEU A 159
 None
 0.54A 2po7B-2z3tA:
undetectable		 2po7B-2z3tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 7 ASP A 383
ALA A 133
PRO A 284
THR A 287
 None
 0.94A 2q6oA-2z3tA:
undetectable		 2q6oA-2z3tA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 ARG A 145
ARG A 144
PRO A 146
 None
 1.12A 2wljA-2z3tA:
undetectable		 2wljA-2z3tA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 ALA A 254
THR A 258
CYH A 364
 HEM  A 500 ( 3.4A)
HEM  A 500 ( 3.4A)
HEM  A 500 (-2.5A)
 0.66A 3e4eA-2z3tA:
30.6		 3e4eA-2z3tA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 ALA A 254
THR A 258
CYH A 364
 HEM  A 500 ( 3.4A)
HEM  A 500 ( 3.4A)
HEM  A 500 (-2.5A)
 0.56A 3e4eB-2z3tA:
30.5		 3e4eB-2z3tA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 ASP A  54
ARG A  58
ARG A 353
 None
 1.03A 3k37A-2z3tA:
undetectable		 3k37A-2z3tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 VAL A 249
VAL A 245
TRP A  97
 None
 0.90A 3l8lA-2z3tA:
undetectable
3l8lB-2z3tA:
undetectable		 3l8lA-2z3tA:
3.87
3l8lB-2z3tA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 12 PHE A 100
ALA A 254
THR A 258
VAL A 301
CYH A 364
 None
HEM  A 500 ( 3.4A)
HEM  A 500 ( 3.4A)
HEM  A 500 ( 4.9A)
HEM  A 500 (-2.5A)
 1.03A 3rukA-2z3tA:
31.5		 3rukA-2z3tA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 11 GLN A 354
PHE A 357
GLY A 358
ALA A 303
ALA A 327
 None
HEM  A 500 (-4.5A)
HEM  A 500 (-3.7A)
None
None
 1.20A 3sufC-2z3tA:
undetectable		 3sufC-2z3tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 12 ASN A 178
ALA A 179
GLN A 183
ARG A 189
LEU A  90
 None
 1.47A 3vhuA-2z3tA:
undetectable		 3vhuA-2z3tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 10 GLY A 246
ALA A  89
VAL A  93
GLU A  95
VAL A 249
 None
 1.20A 4da7A-2z3tA:
undetectable		 4da7A-2z3tA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 GLU A 293
ASP A 346
ASP A 343
 None
 0.75A 4gc9A-2z3tA:
undetectable		 4gc9A-2z3tA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 9 LEU A 369
GLY A 255
VAL A 160
SER A 162
LEU A 165
 None
HEM  A 500 (-3.6A)
None
None
None
 1.19A 4qd3A-2z3tA:
undetectable		 4qd3A-2z3tA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 8 PHE A 357
PHE A 403
GLY A 255
ILE A 161
 HEM  A 500 (-4.5A)
IMD  A 501 (-4.7A)
HEM  A 500 (-3.6A)
None
 0.89A 4qoiA-2z3tA:
undetectable
4qoiB-2z3tA:
undetectable		 4qoiA-2z3tA:
20.42
4qoiB-2z3tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 11 LEU A 294
GLU A 375
LEU A 378
LEU A 280
LEU A 270
 None
 1.10A 4wg0K-2z3tA:
undetectable
4wg0L-2z3tA:
undetectable
4wg0M-2z3tA:
undetectable		 4wg0K-2z3tA:
4.02
4wg0L-2z3tA:
4.02
4wg0M-2z3tA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 5 LEU A  11
ASP A  10
LEU A 328
THR A 305
 None
 1.22A 4wozF-2z3tA:
undetectable
4wozH-2z3tA:
undetectable		 4wozF-2z3tA:
20.97
4wozH-2z3tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 ASP A 215
VAL A 230
LEU A 226
 None
 0.68A 5e5jB-2z3tA:
undetectable		 5e5jB-2z3tA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 ARG A 306
HIS A 106
ARG A  67
 HEM  A 500 (-2.7A)
HEM  A 500 (-3.8A)
HEM  A 500 (-2.3A)
 1.03A 5iaoC-2z3tA:
undetectable		 5iaoC-2z3tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 12 LEU A 113
HIS A 250
LEU A 251
ALA A 254
THR A 114
 None
HEM  A 500 ( 4.8A)
None
HEM  A 500 ( 3.4A)
None
 1.16A 5nd3B-2z3tA:
undetectable		 5nd3B-2z3tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 5 TYR A  26
ASP A 335
PRO A 336
ALA A 332
 None
 0.93A 5otrA-2z3tA:
undetectable		 5otrA-2z3tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		5 / 7 SER A 162
ILE A 161
LEU A 252
LEU A 175
PRO A 157
 None
 1.32A 5u4sA-2z3tA:
undetectable		 5u4sA-2z3tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 7 VAL A  50
VAL A  59
ILE A 312
ILE A 319
 None
 0.78A 5ywmX-2z3tA:
undetectable		 5ywmX-2z3tA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		3 / 3 TYR A  49
ALA A 303
LEU A  11
 None
 0.76A 6d9kF-2z3tA:
undetectable		 6d9kF-2z3tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2z3t CYTOCHROME P450
(Streptomyces
sp.
TP-A0274) 		4 / 7 GLY A 377
HIS A 256
GLU A 150
GLY A 151
 None
 0.89A 6n7fA-2z3tA:
undetectable		 6n7fA-2z3tA:
12.44