SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 VAL A  33
GLY A  32
LEU A  73
PHE A  35
GLU A  19
 None
 1.47A 1a27A-2z4gA:
undetectable		 1a27A-2z4gA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 HIS A   7
HIS A  38
ASP A  46
HIS A 226
ASP A  37
 FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
None
ZN  A 501 (-3.3A)
None
 1.30A 1a4lC-2z4gA:
9.5		 1a4lC-2z4gA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ASP A  46
HIS A  13
HIS A 108
ASP A  82
PRO A  40
 None
ZN  A 501 (-3.3A)
FE  A 502 (-3.5A)
None
None
 1.15A 1ituA-2z4gA:
6.9		 1ituA-2z4gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 GLU A  80
HIS A   5
ASN A 191
TYR A 203
ASP A 224
 FE  A 502 ( 2.6A)
FE  A 503 (-3.5A)
None
None
FE  A 503 (-2.5A)
 1.22A 1ituA-2z4gA:
6.9		 1ituA-2z4gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 GLU A  80
HIS A  38
HIS A 108
ASP A 116
PRO A 118
 FE  A 502 ( 2.6A)
ZN  A 501 (-3.2A)
FE  A 502 (-3.5A)
None
None
 1.41A 1ituA-2z4gA:
6.9		 1ituA-2z4gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 HIS A 108
HIS A   5
ASN A 191
TYR A 203
ASP A 224
 FE  A 502 (-3.5A)
FE  A 503 (-3.5A)
None
None
FE  A 503 (-2.5A)
 1.33A 1ituA-2z4gA:
6.9		 1ituA-2z4gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ASP A  46
HIS A  13
HIS A 108
ASP A  82
PRO A  40
 None
ZN  A 501 (-3.3A)
FE  A 502 (-3.5A)
None
None
 1.17A 1ituB-2z4gA:
5.1		 1ituB-2z4gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 GLU A  80
HIS A  38
HIS A 108
ASP A 116
PRO A 118
 FE  A 502 ( 2.6A)
ZN  A 501 (-3.2A)
FE  A 502 (-3.5A)
None
None
 1.41A 1ituB-2z4gA:
5.1		 1ituB-2z4gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 ASP A 156
LEU A 188
ALA A 174
LEU A 170
 None
 1.16A 1nh8A-2z4gA:
undetectable		 1nh8A-2z4gA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.17A 1os2D-2z4gA:
undetectable		 1os2D-2z4gA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.18A 1uttA-2z4gA:
undetectable		 1uttA-2z4gA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.13A 1utzA-2z4gA:
undetectable		 1utzA-2z4gA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.12A 1utzB-2z4gA:
undetectable		 1utzB-2z4gA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 1v54A-2z4gA:
undetectable		 1v54A-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 1v54N-2z4gA:
undetectable		 1v54N-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.73A 1v55A-2z4gA:
undetectable		 1v55A-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 1v55N-2z4gA:
undetectable		 1v55N-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 ARG A 196
GLU A 230
PHE A 235
TYR A  21
HIS A 226
 None
None
None
None
ZN  A 501 (-3.3A)
 1.40A 1x70A-2z4gA:
undetectable		 1x70A-2z4gA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 TRP A  44
PRO A  42
GLY A  86
GLY A  89
 None
 0.97A 1zlqA-2z4gA:
undetectable		 1zlqA-2z4gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.73A 2dyrA-2z4gA:
undetectable		 2dyrA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 2dyrN-2z4gA:
undetectable		 2dyrN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.75A 2dysA-2z4gA:
undetectable		 2dysA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.75A 2dysN-2z4gA:
undetectable		 2dysN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 10 ASN A 191
LEU A 157
ASP A  37
HIS A 108
ALA A 225
 None
None
None
FE  A 502 (-3.5A)
None
 1.32A 2ecpA-2z4gA:
undetectable		 2ecpA-2z4gA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 10 ASN A 191
LEU A 157
ASP A  37
HIS A 108
ALA A 225
 None
None
None
FE  A 502 (-3.5A)
None
 1.33A 2ecpB-2z4gA:
undetectable		 2ecpB-2z4gA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.71A 2eijA-2z4gA:
undetectable		 2eijA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.73A 2eijN-2z4gA:
undetectable		 2eijN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.72A 2eikA-2z4gA:
undetectable		 2eikA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.75A 2eikN-2z4gA:
undetectable		 2eikN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.73A 2eilA-2z4gA:
undetectable		 2eilA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 2eilN-2z4gA:
undetectable		 2eilN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 2eimA-2z4gA:
undetectable		 2eimA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.72A 2eimN-2z4gA:
undetectable		 2eimN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 2einA-2z4gA:
undetectable		 2einA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.32A 2fqeA-2z4gA:
undetectable		 2fqeA-2z4gA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.16A 2hu6A-2z4gA:
undetectable		 2hu6A-2z4gA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 8 HIS A 108
HIS A 154
ALA A 193
HIS A  38
 FE  A 502 (-3.5A)
FE  A 502 (-3.4A)
None
ZN  A 501 (-3.2A)
 0.90A 2it4A-2z4gA:
undetectable		 2it4A-2z4gA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.10A 2ow9B-2z4gA:
undetectable		 2ow9B-2z4gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.15A 2ozrC-2z4gA:
undetectable		 2ozrC-2z4gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.14A 2ozrD-2z4gA:
undetectable		 2ozrD-2z4gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.16A 2ozrE-2z4gA:
undetectable		 2ozrE-2z4gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A 226
HIS A  13
HIS A  38
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
 0.53A 2ozrF-2z4gA:
undetectable		 2ozrF-2z4gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.78A 2zxwA-2z4gA:
undetectable		 2zxwA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.77A 2zxwN-2z4gA:
undetectable		 2zxwN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.76A 3abmA-2z4gA:
undetectable		 3abmA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.77A 3abmN-2z4gA:
undetectable		 3abmN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.76A 3dtuA-2z4gA:
undetectable		 3dtuA-2z4gA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 11 TYR A 102
THR A  36
PHE A  83
ASP A 189
ILE A 152
 None
 1.39A 3id5F-2z4gA:
undetectable		 3id5F-2z4gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 PHE A 235
GLY A 232
THR A  36
ILE A 104
ILE A 152
 None
 1.39A 3ld6A-2z4gA:
undetectable		 3ld6A-2z4gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.18A 3lilA-2z4gA:
undetectable		 3lilA-2z4gA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 6 HIS A  13
HIS A 226
HIS A  38
ASP A 116
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
None
 1.12A 3nvcA-2z4gA:
undetectable		 3nvcA-2z4gA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 LEU A 209
VAL A 190
HIS A 226
VAL A 238
HIS A   7
 None
None
ZN  A 501 (-3.3A)
None
FE  A 503 (-3.4A)
 1.20A 3sp9B-2z4gA:
undetectable		 3sp9B-2z4gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A 154
HIS A   5
ILE A 104
 FE  A 502 (-3.4A)
FE  A 503 (-3.5A)
None
 0.66A 3u52A-2z4gA:
undetectable
3u52C-2z4gA:
undetectable		 3u52A-2z4gA:
19.81
3u52C-2z4gA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 TYR A 252
VAL A  34
SER A   4
GLY A  32
 None
 1.34A 3v4tA-2z4gA:
undetectable
3v4tD-2z4gA:
undetectable		 3v4tA-2z4gA:
23.91
3v4tD-2z4gA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 12 TYR A  45
LEU A  91
SER A  39
SER A 106
HIS A 150
 None
None
None
FE  A 502 ( 4.1A)
None
 1.28A 3vt7A-2z4gA:
undetectable		 3vt7A-2z4gA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 3wg7A-2z4gA:
undetectable		 3wg7A-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.75A 3wg7N-2z4gA:
undetectable		 3wg7N-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.74A 3x2qN-2z4gA:
undetectable		 3x2qN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 LEU A 157
HIS A  38
GLU A  80
HIS A   7
 None
ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
 1.24A 4a7bB-2z4gA:
undetectable		 4a7bB-2z4gA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 TYR A  45
HIS A  38
ARG A  50
 None
ZN  A 501 (-3.2A)
None
 1.10A 4htfA-2z4gA:
undetectable		 4htfA-2z4gA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 HIS A 108
HIS A 154
HIS A   5
HIS A   7
 FE  A 502 (-3.5A)
FE  A 502 (-3.4A)
FE  A 503 (-3.5A)
FE  A 503 (-3.4A)
 0.86A 4p6sB-2z4gA:
undetectable		 4p6sB-2z4gA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 8 HIS A 154
ASP A 224
HIS A 108
HIS A   7
 FE  A 502 (-3.4A)
FE  A 503 (-2.5A)
FE  A 502 (-3.5A)
FE  A 503 (-3.4A)
 0.89A 5a5zA-2z4gA:
undetectable		 5a5zA-2z4gA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 8 TYR A 251
GLY A 218
GLY A 185
PHE A 187
 None
 0.77A 5albL-2z4gA:
undetectable		 5albL-2z4gA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 HIS A 108
HIS A 154
HIS A   5
HIS A   7
 FE  A 502 (-3.5A)
FE  A 502 (-3.4A)
FE  A 503 (-3.5A)
FE  A 503 (-3.4A)
 0.86A 5i3aA-2z4gA:
undetectable		 5i3aA-2z4gA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 7 HIS A 108
HIS A 154
HIS A   5
HIS A   7
 FE  A 502 (-3.5A)
FE  A 502 (-3.4A)
FE  A 503 (-3.5A)
FE  A 503 (-3.4A)
 0.87A 5i3aB-2z4gA:
undetectable		 5i3aB-2z4gA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.25A 5mejA-2z4gA:
undetectable		 5mejA-2z4gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.26A 5mewA-2z4gA:
undetectable		 5mewA-2z4gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.26A 5mhuA-2z4gA:
undetectable		 5mhuA-2z4gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.27A 5mhvA-2z4gA:
undetectable		 5mhvA-2z4gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.27A 5mhwA-2z4gA:
undetectable		 5mhwA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.27A 5mhxA-2z4gA:
undetectable		 5mhxA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.27A 5mhyA-2z4gA:
undetectable		 5mhyA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.28A 5mhzA-2z4gA:
undetectable		 5mhzA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.28A 5mi1A-2z4gA:
undetectable		 5mi1A-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.28A 5mi2A-2z4gA:
undetectable		 5mi2A-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.28A 5miaA-2z4gA:
undetectable		 5miaA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.28A 5mibA-2z4gA:
undetectable		 5mibA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.27A 5micA-2z4gA:
undetectable		 5micA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.28A 5midA-2z4gA:
undetectable		 5midA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.28A 5mieA-2z4gA:
undetectable		 5mieA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A 226
HIS A   7
HIS A  38
HIS A  13
 ZN  A 501 (-3.3A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
 1.26A 5migA-2z4gA:
undetectable		 5migA-2z4gA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 HIS A  38
GLU A  80
HIS A   7
HIS A 226
 ZN  A 501 (-3.2A)
FE  A 502 ( 2.6A)
FE  A 503 (-3.4A)
ZN  A 501 (-3.3A)
 1.16A 5n5jA-2z4gA:
undetectable		 5n5jA-2z4gA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 6 ASP A 224
HIS A   5
HIS A   7
HIS A 154
HIS A 108
 FE  A 503 (-2.5A)
FE  A 503 (-3.5A)
FE  A 503 (-3.4A)
FE  A 502 (-3.4A)
FE  A 502 (-3.5A)
 1.14A 5nelA-2z4gA:
3.2
5nelD-2z4gA:
3.3		 5nelA-2z4gA:
24.09
5nelD-2z4gA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		5 / 10 LEU A  73
GLY A  76
VAL A   2
LEU A  30
ALA A  25
 None
 1.13A 5o96E-2z4gA:
2.6
5o96F-2z4gA:
3.0		 5o96E-2z4gA:
20.73
5o96F-2z4gA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 4 VAL A 107
VAL A 140
TYR A 136
GLN A 138
 None
 1.48A 5qgqA-2z4gA:
undetectable		 5qgqA-2z4gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 LEU A 208
ALA A 212
LEU A 215
LEU A 219
 None
 0.80A 5vkqA-2z4gA:
undetectable
5vkqD-2z4gA:
undetectable		 5vkqA-2z4gA:
10.22
5vkqD-2z4gA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 LEU A 219
LEU A 208
ALA A 212
LEU A 215
 None
 0.81A 5vkqA-2z4gA:
undetectable
5vkqB-2z4gA:
undetectable		 5vkqA-2z4gA:
10.22
5vkqB-2z4gA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 LEU A 219
LEU A 208
ALA A 212
LEU A 215
 None
 0.83A 5vkqB-2z4gA:
undetectable
5vkqC-2z4gA:
undetectable		 5vkqB-2z4gA:
10.22
5vkqC-2z4gA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 LEU A 219
LEU A 208
ALA A 212
LEU A 215
 None
 0.82A 5vkqC-2z4gA:
undetectable
5vkqD-2z4gA:
undetectable		 5vkqC-2z4gA:
10.22
5vkqD-2z4gA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.78A 5z84A-2z4gA:
undetectable		 5z84A-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.77A 5z84N-2z4gA:
undetectable		 5z84N-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.76A 5z85N-2z4gA:
undetectable		 5z85N-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.75A 5zcpA-2z4gA:
undetectable		 5zcpA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.78A 5zcpN-2z4gA:
undetectable		 5zcpN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.76A 5zcqA-2z4gA:
undetectable		 5zcqA-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		3 / 3 HIS A  38
HIS A  13
HIS A 226
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
 0.76A 5zcqN-2z4gA:
undetectable		 5zcqN-2z4gA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		6 / 12 LEU A 219
LEU A 221
GLY A 222
SER A 106
LEU A 188
ILE A 152
 None
None
None
FE  A 502 ( 4.1A)
None
None
 1.41A 6ecxA-2z4gA:
undetectable		 6ecxA-2z4gA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2z4g HISTIDINOL
PHOSPHATASE
(Thermus
thermophilus) 		4 / 5 TYR A 102
GLY A  78
HIS A   5
ASP A 189
 None
None
FE  A 503 (-3.5A)
None
 1.24A 6gh9A-2z4gA:
undetectable		 6gh9A-2z4gA:
14.98