SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.09A 1usqA-2z4qB:
undetectable		 1usqA-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.76A 1usqB-2z4qB:
undetectable		 1usqB-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.76A 1usqC-2z4qB:
undetectable		 1usqC-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.76A 1usqD-2z4qB:
undetectable		 1usqD-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.77A 1usqE-2z4qB:
undetectable		 1usqE-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.08A 1usqF-2z4qB:
undetectable		 1usqF-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.81A 2jkjA-2z4qB:
undetectable		 2jkjA-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.81A 2jkjB-2z4qB:
undetectable		 2jkjB-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.81A 2jkjC-2z4qB:
undetectable		 2jkjC-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.08A 2jkjE-2z4qB:
undetectable		 2jkjE-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.09A 2jklA-2z4qB:
undetectable		 2jklA-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		4 / 6 GLY B  54
PRO B  53
ILE B  51
GLY B  56
 None
 0.80A 2jklB-2z4qB:
undetectable		 2jklB-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.09A 2jklC-2z4qB:
undetectable		 2jklC-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.08A 2jklD-2z4qB:
undetectable		 2jklD-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.09A 2jklE-2z4qB:
undetectable		 2jklE-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 7 GLY B  54
PRO B  53
THR B  58
ILE B  51
GLY B  56
 None
 1.08A 2jklF-2z4qB:
undetectable		 2jklF-2z4qB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 THR B 121
SER B 208
LYS B 210
 None
 1.09A 3aocC-2z4qB:
undetectable		 3aocC-2z4qB:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER B 208
ALA B 203
VAL B 202
 None
 0.67A 4o2bC-2z4qB:
undetectable		 4o2bC-2z4qB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER B 208
ALA B 203
VAL B 202
 None
 0.58A 5eypA-2z4qB:
undetectable		 5eypA-2z4qB:
18.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		5 / 5 SER B 117
ALA B 119
PHE B 151
LEU B 175
ASP B 178
 None
 0.39A 5mthA-2z4qB:
28.5		 5mthA-2z4qB:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 2z4q ANTI EGFR ANTIBODY
FAB, HEAVY CHAIN
(Mus
musculus) 		3 / 3 SER B 208
ALA B 203
VAL B 202
 None
 0.52A 5xiwC-2z4qB:
undetectable		 5xiwC-2z4qB:
19.71