SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 7 ASP A 232
LEU A 171
SER A 205
ASN A 208
LBT  A2000 ( 2.9A)
None
None
None
1.21A 1ig3A-2z4tA:
3.9
1ig3B-2z4tA:
3.9
1ig3A-2z4tA:
17.33
1ig3B-2z4tA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 12 GLY A 256
VAL A 263
LEU A 307
PHE A 206
ASN A 273
None
1.33A 1nw3A-2z4tA:
3.1
1nw3A-2z4tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 10 GLY A 446
VAL A 464
THR A 360
VAL A 381
HIS A 405
None
None
C5P  A1427 ( 4.5A)
None
C5P  A1427 (-3.9A)
1.24A 1pwyE-2z4tA:
2.7
1pwyE-2z4tA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 12 PHE A  92
LEU A  42
VAL A  40
VAL A 108
THR A 106
None
1.33A 1q23B-2z4tA:
undetectable
1q23B-2z4tA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 11 PHE A  92
LEU A  42
VAL A  40
VAL A 108
THR A 106
None
1.30A 1q23F-2z4tA:
undetectable
1q23F-2z4tA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 7 PHE A 334
ILE A 425
ILE A 429
THR A 437
None
0.98A 1sbrB-2z4tA:
undetectable
1sbrB-2z4tA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 6 ALA A 445
PHE A 357
ILE A 382
VAL A 381
None
0.91A 2cizA-2z4tA:
undetectable
2cizA-2z4tA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 11 GLY A 233
PRO A 127
TYR A 280
TYR A 290
PHE A 292
GOL  A3004 (-3.3A)
None
None
None
None
1.06A 2h21B-2z4tA:
undetectable
2h21B-2z4tA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 11 GLY A 233
PRO A 127
TYR A 280
TYR A 290
PHE A 292
GOL  A3004 (-3.3A)
None
None
None
None
1.06A 2h21C-2z4tA:
undetectable
2h21C-2z4tA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.73A 2p02A-2z4tA:
undetectable
2p02A-2z4tA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 11 ALA A 145
LEU A 194
ILE A 184
LEU A 216
TYR A 120
None
1.33A 2zzaB-2z4tA:
undetectable
2zzaB-2z4tA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
3 / 3 TRP A 282
VAL A 222
ARG A 193
None
0.91A 3b0wA-2z4tA:
undetectable
3b0wA-2z4tA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 12 GLY A 233
LEU A 304
TYR A 280
TYR A 290
PHE A 292
GOL  A3004 (-3.3A)
None
None
None
None
1.14A 3qxyA-2z4tA:
undetectable
3qxyA-2z4tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 11 GLY A 233
LEU A 304
TYR A 280
TYR A 290
PHE A 292
GOL  A3004 (-3.3A)
None
None
None
None
1.16A 3rc0A-2z4tA:
undetectable
3rc0A-2z4tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 12 GLY A 233
LEU A 304
TYR A 280
TYR A 290
PHE A 292
GOL  A3004 (-3.3A)
None
None
None
None
1.15A 3rc0B-2z4tA:
undetectable
3rc0B-2z4tA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
3 / 3 ASN A 226
ASP A 228
ASN A 289
GOL  A3002 (-4.3A)
None
GOL  A3002 (-3.3A)
0.79A 4agaA-2z4tA:
undetectable
4agaA-2z4tA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
3 / 3 PHE A 453
TYR A 241
TYR A 297
None
1.05A 4ffwA-2z4tA:
undetectable
4ffwA-2z4tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 8 ILE A 487
ALA A 477
GLU A 475
VAL A 497
None
0.83A 4jltA-2z4tA:
undetectable
4jltA-2z4tA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 12 VAL A 381
PHE A 357
LEU A 394
VAL A 464
SER A 390
None
1.11A 4po0A-2z4tA:
undetectable
4po0A-2z4tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
3 / 3 ARG A  83
ASP A  36
ARG A 193
None
0.55A 4wq4B-2z4tA:
2.0
4wq4B-2z4tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.71A 5a1iA-2z4tA:
undetectable
5a1iA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 7 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.71A 5a1iA-2z4tA:
undetectable
5a1iA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 4 LEU A 180
ILE A 184
PRO A 211
LEU A 209
None
1.21A 5eb3A-2z4tA:
2.4
5eb3A-2z4tA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
5 / 12 ASP A 231
GLY A 233
ALA A 448
VAL A 485
TYR A 237
None
GOL  A3004 (-3.3A)
None
None
None
1.35A 5kbwB-2z4tA:
undetectable
5kbwB-2z4tA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 6 TYR A 452
ASP A 231
LEU A 293
GLY A 233
None
None
None
GOL  A3004 (-3.3A)
1.04A 5nooC-2z4tA:
undetectable
5nooC-2z4tA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 5 ALA A 385
VAL A 381
PHE A 357
ILE A 447
None
0.86A 5of1A-2z4tA:
undetectable
5of1A-2z4tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 5 ALA A 385
VAL A 381
PHE A 357
ILE A 447
None
0.78A 5of1B-2z4tA:
undetectable
5of1B-2z4tA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 6 PHE A 359
ILE A 415
MET A 416
ASN A 418
None
1.49A 6dhbA-2z4tA:
4.8
6dhbA-2z4tA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
3 / 3 GLN A 346
TYR A 349
ASN A 350
None
0.99A 6dwdC-2z4tA:
undetectable
6dwdC-2z4tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.72A 6fboA-2z4tA:
undetectable
6fboA-2z4tA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.80A 6fcbA-2z4tA:
undetectable
6fcbA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 8 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.71A 6fcdA-2z4tA:
undetectable
6fcdA-2z4tA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
4 / 7 HIS A 123
ASP A 122
SER A 430
ASP A 232
LBT  A2000 ( 4.0A)
MG  A5001 (-4.4A)
C5P  A1427 (-2.7A)
LBT  A2000 ( 2.9A)
0.72A 6g6rA-2z4tA:
undetectable
6g6rA-2z4tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp.
JT-ISH-224)
3 / 3 THR A 109
GLU A  38
ASN A 111
None
0.65A 6nj9K-2z4tA:
2.4
6nj9K-2z4tA:
20.81