SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 9 LEU A  99
ASP A 120
LEU A 116
THR A  50
ILE A  49
 None
 1.44A 1hzeA-2z55A:
undetectable
1hzeB-2z55A:
undetectable		 1hzeA-2z55A:
20.00
1hzeB-2z55A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 9 THR A  50
ILE A  49
LEU A  99
ASP A 120
LEU A 116
 None
 1.44A 1hzeA-2z55A:
undetectable
1hzeB-2z55A:
undetectable		 1hzeA-2z55A:
20.00
1hzeB-2z55A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 10 LEU A  99
ASP A 120
LEU A 116
THR A  50
ILE A  49
 None
 1.37A 1i18A-2z55A:
undetectable
1i18B-2z55A:
undetectable		 1i18A-2z55A:
20.00
1i18B-2z55A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 10 THR A  50
ILE A  49
LEU A  99
ASP A 120
LEU A 116
 None
 1.36A 1i18A-2z55A:
undetectable
1i18B-2z55A:
undetectable		 1i18A-2z55A:
20.00
1i18B-2z55A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 12 LEU A  99
LEU A 102
LEU A 105
ALA A 106
LEU A 158
 None
 0.60A 1ya3C-2z55A:
undetectable		 1ya3C-2z55A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		4 / 5 LEU A 235
GLY A 225
ALA A  43
ILE A 234
 None
 0.83A 2aohB-2z55A:
undetectable		 2aohB-2z55A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 10 ALA A 212
LEU A 216
LEU A 193
ALA A 189
VAL A 196
 None
 0.91A 2bxgB-2z55A:
2.5		 2bxgB-2z55A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 11 GLY A 130
ALA A 131
GLY A 200
ILE A 195
PHE A 213
 None
 0.76A 2fxdA-2z55A:
undetectable		 2fxdA-2z55A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		6 / 12 ALA A 189
LEU A 216
PHE A 213
ALA A 212
VAL A 204
GLY A 202
 None
 1.21A 2ve3A-2z55A:
1.9		 2ve3A-2z55A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		4 / 8 ILE A 234
TYR A  47
ARG A 230
GLY A 225
 None
 0.82A 3b9lA-2z55A:
1.7		 3b9lA-2z55A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		4 / 5 ILE A 234
TYR A  47
ARG A 230
GLY A 225
 None
 0.93A 3b9mA-2z55A:
2.2		 3b9mA-2z55A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 9 VAL A  38
ILE A 234
ALA A  43
ALA A  48
THR A  50
 None
 1.20A 3mdtA-2z55A:
undetectable		 3mdtA-2z55A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 12 LEU A  99
LEU A 102
LEU A 105
ALA A 106
LEU A 158
 None
 0.63A 4ltwA-2z55A:
undetectable		 4ltwA-2z55A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 11 GLY A 223
ILE A  51
THR A  28
GLY A  27
ILE A  26
 None
 0.92A 4qgiA-2z55A:
undetectable		 4qgiA-2z55A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		4 / 6 PHE A 152
ALA A 149
PHE A 145
THR A 126
 22B  A 270 ( 4.1A)
None
22B  A 270 (-3.5A)
None
 1.17A 5t7bA-2z55A:
undetectable		 5t7bA-2z55A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 11 ALA A 165
TYR A  46
LEU A 228
ALA A 106
LEU A 161
 None
 1.36A 6dk1B-2z55A:
undetectable		 6dk1B-2z55A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		4 / 4 ALA A  60
ALA A  63
ALA A  86
ALA A  89
 L2P  A 280 ( 4.8A)
L2P  A 280 ( 4.1A)
L2P  A 280 ( 4.8A)
L2P  A 280 (-3.5A)
 0.51A 6gtqA-2z55A:
undetectable
6gtqB-2z55A:
undetectable		 6gtqA-2z55A:
23.19
6gtqB-2z55A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		4 / 4 ALA A  86
ALA A  89
ALA A  60
ALA A  63
 L2P  A 280 ( 4.8A)
L2P  A 280 (-3.5A)
L2P  A 280 ( 4.8A)
L2P  A 280 ( 4.1A)
 0.50A 6gtqA-2z55A:
undetectable
6gtqB-2z55A:
undetectable		 6gtqA-2z55A:
23.19
6gtqB-2z55A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2z55 ARCHAERHODOPSIN-2
(Halobacterium
sp.
AUS-2) 		5 / 12 THR A  50
ILE A  49
ALA A 164
LEU A 228
LEU A 161
 None
 1.22A 6ie8A-2z55A:
2.9		 6ie8A-2z55A:
25.63