SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 2z5c PROTEIN YPL144W
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  42
VAL A 114
TRP A 116
 None
 0.81A 1av2C-2z5cA:
undetectable
1av2D-2z5cA:
undetectable		 1av2C-2z5cA:
7.94
1av2D-2z5cA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2z5c UNCHARACTERIZED
PROTEIN YLR021W
(Saccharomyces
cerevisiae) 		4 / 4 ILE B 143
LEU B  27
VAL B 169
ILE B 173
 None
 0.85A 1fm6D-2z5cB:
undetectable		 1fm6D-2z5cB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2z5c PROTEIN YPL144W
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 142
ALA A 101
SER A  39
LEU A  40
VAL A  41
 None
 1.20A 2c12C-2z5cA:
undetectable		 2c12C-2z5cA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W
(Saccharomyces
cerevisiae) 		4 / 7 SER A  57
SER A 118
SER A  55
ASN B  36
 None
 1.09A 2cmlA-2z5cA:
undetectable		 2cmlA-2z5cA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 2z5c UNCHARACTERIZED
PROTEIN YLR021W
(Saccharomyces
cerevisiae) 		3 / 3 TYR B   4
TYR B 120
ILE B  38
 None
 0.70A 3eteA-2z5cB:
undetectable
3eteB-2z5cB:
undetectable		 3eteA-2z5cB:
15.10
3eteB-2z5cB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 LEU A 119
GLU A 122
SER A  54
PHE B  34
 None
 1.45A 3i9jB-2z5cA:
undetectable		 3i9jB-2z5cA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W
(Saccharomyces
cerevisiae) 		4 / 8 ARG B  43
SER B 144
TYR A  59
LEU A  27
 None
 1.26A 3jq7B-2z5cB:
undetectable		 3jq7B-2z5cB:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 2z5c PROTEIN YPL144W
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  42
VAL A 114
TRP A 116
 None
 0.76A 3l8lA-2z5cA:
undetectable
3l8lB-2z5cA:
undetectable		 3l8lA-2z5cA:
7.94
3l8lB-2z5cA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W
(Saccharomyces
cerevisiae) 		4 / 8 SER B 140
SER A  55
ASN B  36
SER B 144
 None
 1.14A 5l1fA-2z5cB:
undetectable
5l1fB-2z5cB:
undetectable		 5l1fA-2z5cB:
11.57
5l1fB-2z5cB:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2z5c PROTEIN YPL144W
UNCHARACTERIZED
PROTEIN YLR021W
(Saccharomyces
cerevisiae) 		3 / 3 ARG B  43
PRO A  28
TYR A 113
 None
 1.05A 5tzoB-2z5cB:
undetectable		 5tzoB-2z5cB:
17.88