SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2z5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		5 / 11 GLY A  68
GLY A  59
TYR A  65
ILE A 160
TYR A 163
 None
 0.89A 1p91A-2z5dA:
undetectable		 1p91A-2z5dA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 5 HIS A  95
PRO A  96
TYR A  65
PRO A  64
 None
 1.44A 2ombA-2z5dA:
undetectable
2ombB-2z5dA:
undetectable		 2ombA-2z5dA:
21.52
2ombB-2z5dA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		5 / 11 HIS A  42
VAL A  44
VAL A  55
LEU A 120
THR A 121
 None
 1.25A 3kwaA-2z5dA:
undetectable		 3kwaA-2z5dA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6D_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 6 TRP A  70
PHE A  57
VAL A 105
PRO A  60
 None
 1.34A 3n6dA-2z5dA:
0.0
3n6dB-2z5dA:
undetectable		 3n6dA-2z5dA:
15.80
3n6dB-2z5dA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 5 THR A  32
ILE A  35
LYS A  36
GLU A  39
 None
 0.81A 4ac9C-2z5dA:
undetectable		 4ac9C-2z5dA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 5 THR A  32
ILE A  35
LYS A  36
GLU A  39
 None
 0.80A 4acaC-2z5dA:
undetectable		 4acaC-2z5dA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 5 THR A  32
ILE A  35
LYS A  36
GLU A  39
 None
 0.79A 4acbC-2z5dA:
undetectable		 4acbC-2z5dA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		3 / 3 GLY A  67
GLU A 170
THR A 169
 None
 0.46A 4kouA-2z5dA:
undetectable		 4kouA-2z5dA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 4 VAL A  69
THR A 169
GLU A 170
GLU A 171
 None
 1.21A 4l78A-2z5dA:
undetectable		 4l78A-2z5dA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		5 / 12 ILE A  98
LEU A 128
PHE A  89
ARG A  73
GLY A 103
 None
 1.32A 5il1A-2z5dA:
undetectable		 5il1A-2z5dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 6 HIS A  42
VAL A  55
LEU A 120
THR A 121
 None
 1.32A 5ogjA-2z5dA:
undetectable		 5ogjA-2z5dA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 5 HIS A  42
VAL A  55
LEU A 120
THR A 121
 None
 1.30A 5ohhA-2z5dA:
undetectable		 5ohhA-2z5dA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		5 / 9 HIS A  42
VAL A  44
VAL A  55
LEU A 120
THR A 121
 None
 1.34A 5tt3E-2z5dA:
undetectable		 5tt3E-2z5dA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2z5d UBIQUITIN-CONJUGATIN
G ENZYME E2 H
(Homo
sapiens) 		4 / 5 ILE A 123
PHE A 124
ARG A  73
THR A 104
 None
 1.30A 5z84N-2z5dA:
undetectable
5z84W-2z5dA:
undetectable		 5z84N-2z5dA:
14.79
5z84W-2z5dA:
14.37